Protein Information

Cytoscape View


UniProt AC / UniProt ID P04114 / APOB_HUMAN
Protein Name Apolipoprotein B-100 precursor
Gene Name Name: APOB
Organism Homo sapiens (Human)

PRO ID PR:P04114
DAG View
PRO Name apolipoprotein B-100 (human)
Definition An apolipoprotein B-100 that is encoded in the genome of human.
Short Label hAPOB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P04114 (APOB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Acetylation PRO
Y52 Phosphorylation PhosphoSitePlus
Y129 Phosphorylation PhosphoSitePlus
N185 N-Glycosylation UniProt 19159218
S223 Phosphorylation PhosphoSitePlus
K252 Acetylation PhosphoSitePlus
Y276 Phosphorylation PhosphoSitePlus
T285 Phosphorylation PhosphoSitePlus
S296 Phosphorylation PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus
S520 Phosphorylation HPRD   PhosphoSitePlus 19413330
Y562 Phosphorylation PhosphoSitePlus
R567 Methylation PhosphoSitePlus
K612 Acetylation PhosphoSitePlus
Y740 Phosphorylation PhosphoSitePlus
T741 Phosphorylation PhosphoSitePlus
S767 Phosphorylation PhosphoSitePlus
S928 Phosphorylation HPRD   PhosphoSitePlus 18691976
T1102 Phosphorylation PhosphoSitePlus
T1114 Phosphorylation PhosphoSitePlus
S1135 Phosphorylation PhosphoSitePlus
Y1157 Phosphorylation PhosphoSitePlus
Y1169 Phosphorylation PhosphoSitePlus
T1190 Phosphorylation PhosphoSitePlus
S1191 Phosphorylation PhosphoSitePlus
S1198 Phosphorylation PhosphoSitePlus
Y1200 Phosphorylation PhosphoSitePlus
S1235 Phosphorylation PhosphoSitePlus
Y1287 Phosphorylation PhosphoSitePlus
T1288 Phosphorylation PhosphoSitePlus
N1523 N-Glycosylation UniProt 16335952, 19159218
S1709 Phosphorylation PhosphoSitePlus
Y1714 Phosphorylation HPRD   PhosphoSitePlus 20068231
S1723 Phosphorylation HPRD 20068231
Y1774 Phosphorylation PhosphoSitePlus
S1775 Phosphorylation PhosphoSitePlus
K1778 Acetylation PhosphoSitePlus
Y1840 Phosphorylation PhosphoSitePlus
Y1946 Phosphorylation PhosphoSitePlus
K2004 Acetylation PhosphoSitePlus   UniProt 19608861
T2013 Phosphorylation PhosphoSitePlus
T2018 Phosphorylation HPRD 20068231
S2022 Phosphorylation HPRD 20068231
S2211 Phosphorylation PhosphoSitePlus
N2239 N-Glycosylation UniProt 19159218
K2265 Acetylation PhosphoSitePlus
Y2480 Phosphorylation PhosphoSitePlus
T2515 Phosphorylation HPRD   PhosphoSitePlus 19664994
S2603 Phosphorylation PhosphoSitePlus
T2707 Phosphorylation HPRD   PhosphoSitePlus 20068231
N2779 N-Glycosylation UniProt 19159218
Y2834 Phosphorylation PhosphoSitePlus
S2859 Phosphorylation PhosphoSitePlus
T2862 Phosphorylation PhosphoSitePlus
K2911 Ubiquitination PhosphoSitePlus
K2915 Ubiquitination PhosphoSitePlus
K2926 Ubiquitination PhosphoSitePlus
N2982 N-Glycosylation UniProt 16335952, 19159218
N3101 N-Glycosylation UniProt 19159218
S3185 Phosphorylation PhosphoSitePlus
S3198 Phosphorylation PhosphoSitePlus
T3220 O-Glycosylation PhosphoSitePlus
N3224 N-Glycosylation UniProt 19159218
S3279 Phosphorylation PhosphoSitePlus   UniProt 24275569
S3282 Phosphorylation PhosphoSitePlus
S3288 Phosphorylation PhosphoSitePlus
N3358 N-Glycosylation UniProt 14760718
T3397 Phosphorylation PhosphoSitePlus
S3400 Phosphorylation PhosphoSitePlus
S3402 Phosphorylation PhosphoSitePlus
N3411 N-Glycosylation UniProt 19159218
N3465 N-Glycosylation UniProt 16335952, 19159218
T3472 Phosphorylation PhosphoSitePlus
T3626 Phosphorylation PhosphoSitePlus
S3643 Phosphorylation PhosphoSitePlus
S3646 Phosphorylation PhosphoSitePlus
Y3680 Phosphorylation PhosphoSitePlus
T3776 Phosphorylation HPRD 20068231
S3778 Phosphorylation HPRD   PhosphoSitePlus 20068231
T3785 Phosphorylation PhosphoSitePlus
N3895 N-Glycosylation UniProt 16335952, 19159218
Y3958 Phosphorylation PhosphoSitePlus
S4000 Phosphorylation PhosphoSitePlus
Y4025 Phosphorylation PhosphoSitePlus
Y4026 Phosphorylation PhosphoSitePlus
S4027 Phosphorylation PhosphoSitePlus
S4030 Phosphorylation PhosphoSitePlus
K4040 Acetylation PhosphoSitePlus
T4041 Phosphorylation PhosphoSitePlus
S4048 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20166139, 26091039, 24275569
T4052 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y4116 Phosphorylation PhosphoSitePlus
T4140 Phosphorylation PhosphoSitePlus
S4229 Phosphorylation PhosphoSitePlus
S4409 Phosphorylation PhosphoSitePlus
S4507 Phosphorylation HPRD   PhosphoSitePlus 17924679
Y4510 Phosphorylation HPRD   PhosphoSitePlus 19562805


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046358 (hAPOB/SigPep-/N6AcLys+) ac PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S296 I296 Biomuta DOID:1324 / lung cancer [ tcga ]
S312 R312 Biomuta DOID:1324 / lung cancer [ tcga ]
S312 C312 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R567 T567 Biomuta DOID:3571 / liver cancer [ icgc ]
T741 S741 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T1102 S1102 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T1114 I1114 Biomuta DOID:11934 / head and neck cancer [ tcga ]
Y1169 C1169 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
Y1169 * Biomuta DOID:363 / uterine cancer [ tcga ]
T1190 N1190 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:3070 / malignant glioma [ tcga ]
S1191 F1191 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S1723 I1723 Biomuta DOID:1115 / sarcoma [ tcga ]
S1775 I1775 Biomuta DOID:8618 / oral cavity cancer [ icgc ]
Y1946 C1946 Biomuta DOID:0070003 / blastoma [ cosmic ]
S2022 F2022 Biomuta DOID:9256 / colorectal cancer [ icgc ]
N2239 K2239 Biomuta DOID:9256 / colorectal cancer [ tcga ]
Y2480 N2480 Biomuta DOID:3070 / malignant glioma [ tcga ]
N2779 I2779 Biomuta DOID:11934 / head and neck cancer [ icgc, tcga ]
Y2834 C2834 Biomuta DOID:363 / uterine cancer [ tcga ]
S2859 R2859 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S3282 N3282 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T3397 I3397 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S3402 R3402 Biomuta DOID:2394 / ovarian cancer [ icgc ] DOID:2994 / germ cell cancer [ cosmic ]
N3411 K3411 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ] DOID:2394 / ovarian cancer [ tcga ]
T3472 N3472 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S3643 Y3643 Biomuta DOID:263 / kidney cancer [ cosmic ]
Y3958 C3958 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
Y4025 S4025 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S4027 N4027 Biomuta DOID:1909 / melanoma [ cosmic ]
S4027 C4027 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]