iPTMnet Report for P04083 (ANXA1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P04083 / ANXA1_HUMAN
Protein Name Annexin A1
Gene Name Name: ANXA1
Synonyms:ANX1,LPC1;
Organism Homo sapiens (Human)

PRO ID PR:P04083
DAG View
PRO Name annexin A1 (human)
Definition An annexin A1 that is encoded in the genome of human.
Short Label hANXA1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P04083 (ANXA1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 3303336
S5 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24103589, 21280599, 15485879, ...20068231
S5 Phosphorylation Q96QT4 (TRPM7) HPRD   PhosphoSitePlus   Signor 24103589, 15485879, 20068231
Y21 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 24782913, 24103589, 2457390, ...22792315
Y21 Phosphorylation A0A173G4P4 (Abl fusion) phospho.ELM 2457390
Y21 Phosphorylation P00519 (ABL1) PhosphoSitePlus 2457390
Y21 Phosphorylation P00533 (EGFR) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 24103589, 2457390
Y21 Phosphorylation P12931 (SRC) HPRD   phospho.ELM   PhosphoSitePlus   Signor 24103589, 2457390
Y21 Phosphorylation P17252 (PRKCA) RLIMS-P+ 2457390
T24 Phosphorylation phospho.ELM   PhosphoSitePlus 1956339
K26 Ubiquitination PhosphoSitePlus
S27 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 2457390, 24782913, 19428336, ...24103589, 34944403
S27 Phosphorylation P05129 (PRKCG) Signor 24103589
S27 Phosphorylation P05771 (PRKCB) Signor 24103589
S27 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   RLIMS-P+   Signor 24103589, 2457390
S27 Phosphorylation P24723 (PRKCH) Signor 24103589
S27 Phosphorylation P41743 (PRKCI) HPRD 2457390
S28 Phosphorylation phospho.ELM   PhosphoSitePlus 19428336, 1956339
S28 Phosphorylation P05771 (PRKCB) PhosphoSitePlus 19428336
S28 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 19428336
K29 Ubiquitination PhosphoSitePlus
S34 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S37 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S37 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
Y39 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107, 18669648
T41 Phosphorylation PhosphoSitePlus   UniProt 23186163
S45 Phosphorylation PhosphoSitePlus
K53 Acetylation PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
T64 Phosphorylation PhosphoSitePlus
T70 Phosphorylation PhosphoSitePlus
K71 Acetylation PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
Y84 Phosphorylation PhosphoSitePlus
T88 Phosphorylation PhosphoSitePlus
K90 Acetylation PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
T95 Phosphorylation PhosphoSitePlus
K97 Acetylation PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
K98 Acetylation PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
T101 Phosphorylation PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
T114 Phosphorylation PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
T132 Phosphorylation PhosphoSitePlus
T136 Phosphorylation PhosphoSitePlus   UniProt 23186163
S143 Phosphorylation PhosphoSitePlus
Y156 Phosphorylation PhosphoSitePlus
K161 Acetylation PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
K166 Acetylation PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
T169 Phosphorylation PhosphoSitePlus
S170 Phosphorylation HPRD   PhosphoSitePlus 18491316
T172 Phosphorylation PhosphoSitePlus
S173 Phosphorylation PhosphoSitePlus
S182 Phosphorylation PhosphoSitePlus
K185 Acetylation PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
S189 Phosphorylation PhosphoSitePlus
S201 Phosphorylation PhosphoSitePlus
Y207 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107, 15592455
K214 Sumoylation PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
T216 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   Signor 2457390, 24103589
T216 Phosphorylation P12931 (SRC) Signor 24103589
T216 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 2457390
T226 Phosphorylation PhosphoSitePlus
K239 Acetylation PhosphoSitePlus   UniProt 19608861
K239 Ubiquitination PhosphoSitePlus
K242 Acetylation PhosphoSitePlus
K245 Acetylation PhosphoSitePlus
K250 Acetylation PhosphoSitePlus
K250 Ubiquitination PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
K274 Methylation PhosphoSitePlus
K274 Ubiquitination PhosphoSitePlus
K281 Acetylation PhosphoSitePlus
K281 Methylation PhosphoSitePlus
K281 Ubiquitination PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
K294 Acetylation PhosphoSitePlus
K312 Acetylation PhosphoSitePlus   UniProt 19608861
K312 Sumoylation PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus
K317 Ubiquitination PhosphoSitePlus
C324 S-Nitrosylation dbSNO 25040305, 20140087, 22178444
K332 Sumoylation PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus
Y335 Phosphorylation PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus
C343 S-Nitrosylation dbSNO 26338901, 22178444, 20140087


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P04083 (ANXA1) S5 P31949 (S100A11) decreased_association eFIP 21280599


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S27 L27 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K29 N29 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T64 A64 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T64 I64 Biomuta DOID:4159 / skin cancer [ cosmic ]
T101 A101 Biomuta DOID:4362 / cervical cancer [ icgc ]
T132 A132 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S143 L143 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S170 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K294 R294 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y335 C335 Biomuta DOID:363 / uterine cancer [ icgc ]