Protein Information

Cytoscape View


UniProt AC / UniProt ID P04050 / RPB1_YEAST
Protein Name DNA-directed RNA polymerase II subunit RPB1
Gene Name Name: RPO21
Synonyms:RPB1,RPB220,SUA8;OrderedLocusNames:YDL140C;ORFNames:D2150;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

PRO ID PR:P04050
DAG View
PRO Name DNA-directed RNA polymerase II subunit RPB1 (yeast)
Definition A protein that is a translation product of the RPO21 gene in yeast.
Short Label yRPO21
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P04050 (RPO21) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation RLIMS-P 19679665
K143 Ubiquitination SGD 23749301
K145 Ubiquitination SGD 23749301
K186 Ubiquitination SGD 23749301
T191 Phosphorylation SGD 23749301
K330 Ubiquitination SGD 17418786
K368 Ubiquitination SGD 23749301
K372 Ubiquitination SGD 23749301
T595 Phosphorylation PhosphoGrid 21177495
T596 Phosphorylation PhosphoGrid 21177495
S599 Phosphorylation PhosphoGrid 21177495
T621 Phosphorylation PhosphoGrid 17563356
K687 Ubiquitination SGD 23749301
K689 Ubiquitination SGD 23749301
K695 Ubiquitination SGD   UniProt 17418786, 22106047, 23749301
K705 Ubiquitination SGD 23749301
K738 Ubiquitination SGD 23749301
K744 Ubiquitination SGD 23749301
K789 Ubiquitination SGD 23749301
K797 Ubiquitination SGD 23749301
K830 Ubiquitination SGD 23749301
K843 Ubiquitination SGD 23749301
K895 Ubiquitination SGD 23749301
K1003 Ubiquitination SGD 23749301
K1039 Ubiquitination SGD 23749301
K1093 Ubiquitination SGD 23749301
K1102 Ubiquitination SGD 23749301
K1205 Ubiquitination SGD 23749301
K1246 Ubiquitination SGD   UniProt 22106047, 23793018, 23749301
K1286 Ubiquitination SGD 23749301
S1293 Phosphorylation PhosphoGrid 17330950, 21126336
K1350 Ubiquitination SGD   UniProt 22106047, 23749301
T1471 Phosphorylation PhosphoGrid   RLIMS-P   SGD   UniProt 31085683, 20489023, 18407956, ...28826505
Y1473 Phosphorylation PhosphoGrid   RLIMS-P   SGD 28826505, 18407956
K1487 Sumoylation SGD 19384408
S1493 Phosphorylation RLIMS-P 31085683, 28826505
S1543 Phosphorylation P46962 (CTK2) , Q03957 (CTK1) PhosphoGrid 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1546 Phosphorylation Q05949 (BUR2) , P23293 (SGV1) , P06242 (KIN28) , P37366 (CCL1) PhosphoGrid 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1550 Phosphorylation P46962 (CTK2) , Q03957 (CTK1) PhosphoGrid 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1553 Phosphorylation P23293 (SGV1) , P06242 (KIN28) , Q05949 (BUR2) , P37366 (CCL1) PhosphoGrid 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1557 Phosphorylation P46962 (CTK2) , Q03957 (CTK1) PhosphoGrid 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1560 Phosphorylation P37366 (CCL1) , Q05949 (BUR2) , P23293 (SGV1) , P06242 (KIN28) PhosphoGrid 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1562 Phosphorylation P06242 (KIN28) , P37366 (CCL1) PhosphoGrid 20835241, 19450536, 20818391, ...19679665
S1564 Phosphorylation Q03957 (CTK1) , P46962 (CTK2) PhosphoGrid 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1567 Phosphorylation P06242 (KIN28) , P37366 (CCL1) , P23293 (SGV1) , Q05949 (BUR2) PhosphoGrid 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1569 Phosphorylation P06242 (KIN28) , P37366 (CCL1) PhosphoGrid 20835241, 19450536, 20818391, ...19679665
S1571 Phosphorylation P46962 (CTK2) , Q03957 (CTK1) PhosphoGrid 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1574 Phosphorylation Q05949 (BUR2) , P23293 (SGV1) , P37366 (CCL1) , P06242 (KIN28) PhosphoGrid 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1576 Phosphorylation P37366 (CCL1) , P06242 (KIN28) PhosphoGrid 20835241, 19450536, 20818391, ...19679665
S1578 Phosphorylation Q03957 (CTK1) , P46962 (CTK2) PhosphoGrid 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1581 Phosphorylation P06242 (KIN28) , Q05949 (BUR2) , P23293 (SGV1) , P37366 (CCL1) PhosphoGrid 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1583 Phosphorylation P06242 (KIN28) , P37366 (CCL1) PhosphoGrid 20835241, 19450536, 20818391, ...19679665
S1585 Phosphorylation P46962 (CTK2) , Q03957 (CTK1) PhosphoGrid 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1588 Phosphorylation P23293 (SGV1) , Q05949 (BUR2) , P37366 (CCL1) , P06242 (KIN28) PhosphoGrid 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1590 Phosphorylation P37366 (CCL1) , P06242 (KIN28) PhosphoGrid 20835241, 19450536, 20818391, ...19679665
S1592 Phosphorylation P46962 (CTK2) , Q03957 (CTK1) PhosphoGrid 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1595 Phosphorylation P06242 (KIN28) , P37366 (CCL1) , P23293 (SGV1) , Q05949 (BUR2) PhosphoGrid 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1597 Phosphorylation P06242 (KIN28) , P37366 (CCL1) PhosphoGrid 20835241, 19450536, 20818391, ...19679665
S1599 Phosphorylation P46962 (CTK2) , Q03957 (CTK1) PhosphoGrid 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1602 Phosphorylation Q05949 (BUR2) , P06242 (KIN28) , P37366 (CCL1) , P23293 (SGV1) PhosphoGrid 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1604 Phosphorylation P37366 (CCL1) , P06242 (KIN28) PhosphoGrid 20835241, 19450536, 20818391, ...19679665
S1606 Phosphorylation Q03957 (CTK1) , P46962 (CTK2) PhosphoGrid 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1609 Phosphorylation P06242 (KIN28) , P23293 (SGV1) , Q05949 (BUR2) , P37366 (CCL1) PhosphoGrid 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1611 Phosphorylation P37366 (CCL1) , P06242 (KIN28) PhosphoGrid 20835241, 19450536, 20818391, ...19679665
S1613 Phosphorylation Q03957 (CTK1) , P46962 (CTK2) PhosphoGrid 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1616 Phosphorylation Q05949 (BUR2) , P23293 (SGV1) , P37366 (CCL1) , P06242 (KIN28) PhosphoGrid 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1618 Phosphorylation P37366 (CCL1) , P06242 (KIN28) PhosphoGrid 20835241, 19450536, 20818391, ...19679665
S1620 Phosphorylation Q03957 (CTK1) , P46962 (CTK2) PhosphoGrid 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1623 Phosphorylation P23293 (SGV1) , P06242 (KIN28) , P37366 (CCL1) , Q05949 (BUR2) PhosphoGrid 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1625 Phosphorylation P37366 (CCL1) , P06242 (KIN28) PhosphoGrid 20835241, 19450536, 20818391, ...19679665
S1627 Phosphorylation P46962 (CTK2) , Q03957 (CTK1) PhosphoGrid 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1630 Phosphorylation Q05949 (BUR2) , P23293 (SGV1) , P37366 (CCL1) , P06242 (KIN28) PhosphoGrid 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1632 Phosphorylation P06242 (KIN28) , P37366 (CCL1) PhosphoGrid 20835241, 19450536, 20818391, ...19679665
S1634 Phosphorylation Q03957 (CTK1) , P46962 (CTK2) PhosphoGrid 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1637 Phosphorylation P23293 (SGV1) , P37366 (CCL1) , Q05949 (BUR2) , P06242 (KIN28) PhosphoGrid 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1639 Phosphorylation P06242 (KIN28) , P37366 (CCL1) PhosphoGrid 20835241, 19450536, 20818391, ...19679665
S1641 Phosphorylation P46962 (CTK2) , Q03957 (CTK1) PhosphoGrid 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1644 Phosphorylation Q05949 (BUR2) , P23293 (SGV1) , P06242 (KIN28) , P37366 (CCL1) PhosphoGrid 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1646 Phosphorylation P06242 (KIN28) , P37366 (CCL1) PhosphoGrid 20835241, 19450536, 20818391, ...19679665
S1648 Phosphorylation Q03957 (CTK1) , P46962 (CTK2) PhosphoGrid 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1651 Phosphorylation P23293 (SGV1) , Q05949 (BUR2) , P06242 (KIN28) , P37366 (CCL1) PhosphoGrid 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1653 Phosphorylation P06242 (KIN28) , P37366 (CCL1) PhosphoGrid 20835241, 19450536, 20818391, ...19679665
S1655 Phosphorylation Q03957 (CTK1) , P46962 (CTK2) PhosphoGrid 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1658 Phosphorylation P37366 (CCL1) , Q05949 (BUR2) , P06242 (KIN28) , P23293 (SGV1) PhosphoGrid 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1662 Phosphorylation P46962 (CTK2) , Q03957 (CTK1) PhosphoGrid 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1665 Phosphorylation P37366 (CCL1) , P23293 (SGV1) , P06242 (KIN28) , Q05949 (BUR2) PhosphoGrid 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1667 Phosphorylation P37366 (CCL1) , P06242 (KIN28) PhosphoGrid 20835241, 19450536, 20818391, ...19679665
S1669 Phosphorylation Q03957 (CTK1) , P46962 (CTK2) PhosphoGrid 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1672 Phosphorylation P37366 (CCL1) , P23293 (SGV1) , Q05949 (BUR2) , P06242 (KIN28) PhosphoGrid 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1674 Phosphorylation P06242 (KIN28) , P37366 (CCL1) PhosphoGrid 20835241, 19450536, 20818391, ...19679665
S1676 Phosphorylation Q03957 (CTK1) , P46962 (CTK2) PhosphoGrid 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1679 Phosphorylation P06242 (KIN28) , P37366 (CCL1) , Q05949 (BUR2) , P23293 (SGV1) PhosphoGrid 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1681 Phosphorylation P37366 (CCL1) , P06242 (KIN28) PhosphoGrid 20835241, 19450536, 20818391, ...19679665
S1683 Phosphorylation Q03957 (CTK1) , P46962 (CTK2) PhosphoGrid 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1686 Phosphorylation P37366 (CCL1) , Q05949 (BUR2) , P23293 (SGV1) , P06242 (KIN28) PhosphoGrid 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1688 Phosphorylation P06242 (KIN28) , P37366 (CCL1) PhosphoGrid 20835241, 19450536, 20818391, ...19679665
S1690 Phosphorylation P46962 (CTK2) , Q03957 (CTK1) PhosphoGrid 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1693 Phosphorylation P06242 (KIN28) , P37366 (CCL1) , P23293 (SGV1) , Q05949 (BUR2) PhosphoGrid 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1697 Phosphorylation P46962 (CTK2) , Q03957 (CTK1) PhosphoGrid 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1700 Phosphorylation P06242 (KIN28) , Q05949 (BUR2) , P37366 (CCL1) , P23293 (SGV1) PhosphoGrid 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1702 Phosphorylation P37366 (CCL1) , P06242 (KIN28) PhosphoGrid 20835241, 19450536, 20818391, ...19679665
S1704 Phosphorylation Q03957 (CTK1) , P46962 (CTK2) PhosphoGrid 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1707 Phosphorylation P37366 (CCL1) , Q05949 (BUR2) , P06242 (KIN28) , P23293 (SGV1) PhosphoGrid 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1711 Phosphorylation Q03957 (CTK1) , P46962 (CTK2) PhosphoGrid 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1714 Phosphorylation P06242 (KIN28) , P23293 (SGV1) , Q05949 (BUR2) , P37366 (CCL1) PhosphoGrid 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1718 Phosphorylation Q03957 (CTK1) , P46962 (CTK2) PhosphoGrid 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P04050 (RPO21) T1471 P23615 (SPT6) increased_association eFIP 28826505