iPTMnet Report for P04050 (RPO21)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P04050 / RPB1_YEAST
Protein Name DNA-directed RNA polymerase II subunit RPB1
Gene Name Name: RPO21
Synonyms:RPB1,RPB220,SUA8;OrderedLocusNames:YDL140C;ORFNames:D2150;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

PRO ID PR:P04050
DAG View
PRO Name DNA-directed RNA polymerase II subunit RPB1 (yeast)
Definition A DNA-directed RNA polymerase II subunit RPB1 that is encoded in the genome of yeast.
Short Label yPOLR2A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P04050 (RPO21) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation RLIMS-P   SGD 33491328, 19679665
S8 Phosphorylation SGD 33491328
S23 Phosphorylation SGD 33481703
K143 Ubiquitination SGD 23749301
K145 Ubiquitination SGD 23749301
K180 Acetylation SGD 30181345
K186 Ubiquitination SGD 23749301
T191 Phosphorylation SGD 23749301, 33491328
K330 Ubiquitination SGD 17418786
K368 Ubiquitination SGD 23749301
K372 Ubiquitination SGD 23749301
K419 Acetylation SGD 30181345
K431 Acetylation SGD 30181345
S449 Phosphorylation SGD 32597660, 33491328
S466 Phosphorylation SGD 33491328
S473 Phosphorylation SGD 33491328
S476 Phosphorylation SGD 33491328
S513 Phosphorylation SGD 33491328
T595 Phosphorylation BioGRID 21177495
T596 Phosphorylation BioGRID 21177495
S599 Phosphorylation BioGRID   SGD 21177495, 33481703, 33491328
K601 Acetylation SGD 30181345
K620 Acetylation SGD 30181345
T621 Phosphorylation BioGRID 17563356
K687 Ubiquitination SGD 23749301
K689 Ubiquitination SGD 23749301
K695 Ubiquitination SGD   UniProt 17418786, 30489083, 22106047, ...23749301
K705 Acetylation SGD 30181345
K705 Ubiquitination SGD 23749301
K728 Acetylation SGD 30181345
K738 Ubiquitination SGD 30489083, 23749301
K744 Ubiquitination SGD 23749301
S751 Phosphorylation SGD 33491328
K789 Ubiquitination SGD 23749301
S793 Phosphorylation SGD 33491328
K797 Ubiquitination SGD 23749301
K830 Ubiquitination SGD 23749301
K843 Ubiquitination SGD 23749301
K895 Ubiquitination SGD 23749301
K1003 Acetylation SGD 30181345
K1003 Ubiquitination SGD 23749301
K1039 Ubiquitination SGD 23749301
K1093 Acetylation SGD 30181345
K1093 Ubiquitination SGD 23749301
K1102 Acetylation SGD 30181345
K1102 Ubiquitination SGD 23749301
S1136 Phosphorylation SGD 33491328
K1205 Acetylation SGD 30181345
K1205 Ubiquitination SGD 30489083, 23749301
K1246 Ubiquitination SGD   UniProt 22106047, 23793018, 23749301, ...32142654
S1247 Phosphorylation SGD 33491328
K1261 Acetylation SGD 30181345
K1262 Acetylation SGD 30181345
T1266 Phosphorylation SGD 30181345
K1286 Ubiquitination SGD 23749301
K1290 Acetylation SGD 30181345
S1293 Phosphorylation BioGRID   SGD 17330950, 30181345, 21126336, ...33481703, 33491328
K1350 Ubiquitination SGD   UniProt 22106047, 23749301
T1394 Phosphorylation SGD 33491328
S1449 Phosphorylation SGD 33491328
T1460 Phosphorylation SGD 33481703
T1471 Phosphorylation BioGRID   RLIMS-P   SGD   UniProt 33481703, 20489023, 18407956, ...31085683, 30181345, 27821475, 33491328, 28826505
Y1473 Phosphorylation BioGRID   RLIMS-P   SGD 28826505, 18407956, 33481703
S1474 Phosphorylation SGD 33481703
K1487 Sumoylation SGD 33502312, 19384408
S1493 Phosphorylation RLIMS-P   SGD 31085683, 28826505
S1521 Phosphorylation SGD 33491328
S1532 Phosphorylation SGD 33491328
S1543 Phosphorylation P46962 (CTK2) , Q03957 (CTK1) BioGRID 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1546 Phosphorylation Q05949 (BUR2) , P23293 (SGV1) , P06242 (KIN28) , P37366 (CCL1) BioGRID 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1550 Phosphorylation P46962 (CTK2) , Q03957 (CTK1) BioGRID   SGD 11018013, 10594013, 12972617, ...20818391, 9237170, 33491328, 11751637
S1553 Phosphorylation P23293 (SGV1) , P06242 (KIN28) , Q05949 (BUR2) , P37366 (CCL1) BioGRID 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1557 Phosphorylation P46962 (CTK2) , Q03957 (CTK1) IntAct   BioGRID 11018013, 10594013, 12972617, ...20818391, 9237170, 22796944, 11751637
T1559 Phosphorylation SGD 33491328
S1560 Phosphorylation P37366 (CCL1) , Q05949 (BUR2) , P23293 (SGV1) , P06242 (KIN28) IntAct   BioGRID 11018013, 10594013, 12972617, ...9237170, 20818391, 11390638, 22796944
S1562 Phosphorylation P06242 (KIN28) , P37366 (CCL1) IntAct   BioGRID 20835241, 22796944, 19450536, ...20818391, 19679665
S1564 Phosphorylation P46962 (CTK2) , Q03957 (CTK1) BioGRID 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1567 Phosphorylation P06242 (KIN28) , P37366 (CCL1) , P23293 (SGV1) , Q05949 (BUR2) BioGRID 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1569 Phosphorylation P06242 (KIN28) , P37366 (CCL1) BioGRID 20835241, 19450536, 20818391, ...19679665
S1571 Phosphorylation P46962 (CTK2) , Q03957 (CTK1) BioGRID   SGD 11018013, 10594013, 12972617, ...20818391, 9237170, 33491328, 11751637
S1574 Phosphorylation Q05949 (BUR2) , P23293 (SGV1) , P37366 (CCL1) , P06242 (KIN28) BioGRID 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1576 Phosphorylation P37366 (CCL1) , P06242 (KIN28) BioGRID 20835241, 19450536, 20818391, ...19679665
S1578 Phosphorylation Q03957 (CTK1) , P46962 (CTK2) BioGRID 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1581 Phosphorylation P06242 (KIN28) , Q05949 (BUR2) , P23293 (SGV1) , P37366 (CCL1) BioGRID 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1583 Phosphorylation P06242 (KIN28) , P37366 (CCL1) BioGRID 20835241, 19450536, 20818391, ...19679665
S1585 Phosphorylation P46962 (CTK2) , Q03957 (CTK1) BioGRID 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1588 Phosphorylation P23293 (SGV1) , Q05949 (BUR2) , P37366 (CCL1) , P06242 (KIN28) BioGRID 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1590 Phosphorylation P37366 (CCL1) , P06242 (KIN28) BioGRID 20835241, 19450536, 20818391, ...19679665
S1592 Phosphorylation P46962 (CTK2) , Q03957 (CTK1) BioGRID 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1595 Phosphorylation P06242 (KIN28) , P37366 (CCL1) , P23293 (SGV1) , Q05949 (BUR2) BioGRID 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1597 Phosphorylation P06242 (KIN28) , P37366 (CCL1) BioGRID 20835241, 19450536, 20818391, ...19679665
S1599 Phosphorylation P46962 (CTK2) , Q03957 (CTK1) BioGRID 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1602 Phosphorylation Q05949 (BUR2) , P06242 (KIN28) , P37366 (CCL1) , P23293 (SGV1) BioGRID 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1604 Phosphorylation P37366 (CCL1) , P06242 (KIN28) BioGRID 20835241, 19450536, 20818391, ...19679665
S1606 Phosphorylation Q03957 (CTK1) , P46962 (CTK2) BioGRID 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1609 Phosphorylation P06242 (KIN28) , P23293 (SGV1) , P37366 (CCL1) , Q05949 (BUR2) BioGRID 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1611 Phosphorylation P37366 (CCL1) , P06242 (KIN28) BioGRID 20835241, 19450536, 20818391, ...19679665
S1613 Phosphorylation Q03957 (CTK1) , P46962 (CTK2) BioGRID 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1616 Phosphorylation Q05949 (BUR2) , P23293 (SGV1) , P37366 (CCL1) , P06242 (KIN28) BioGRID 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1618 Phosphorylation P37366 (CCL1) , P06242 (KIN28) BioGRID 20835241, 19450536, 20818391, ...19679665
S1620 Phosphorylation Q03957 (CTK1) , P46962 (CTK2) BioGRID 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1623 Phosphorylation P23293 (SGV1) , P06242 (KIN28) , P37366 (CCL1) , Q05949 (BUR2) BioGRID 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1625 Phosphorylation P37366 (CCL1) , P06242 (KIN28) BioGRID 20835241, 19450536, 20818391, ...19679665
S1627 Phosphorylation Q03957 (CTK1) , P46962 (CTK2) BioGRID 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1630 Phosphorylation Q05949 (BUR2) , P23293 (SGV1) , P37366 (CCL1) , P06242 (KIN28) BioGRID 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1632 Phosphorylation P37366 (CCL1) , P06242 (KIN28) BioGRID 20835241, 19450536, 20818391, ...19679665
S1634 Phosphorylation Q03957 (CTK1) , P46962 (CTK2) BioGRID 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1637 Phosphorylation P23293 (SGV1) , P37366 (CCL1) , Q05949 (BUR2) , P06242 (KIN28) BioGRID 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1639 Phosphorylation P06242 (KIN28) , P37366 (CCL1) BioGRID 20835241, 19450536, 20818391, ...19679665
S1641 Phosphorylation P46962 (CTK2) , Q03957 (CTK1) BioGRID 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1644 Phosphorylation Q05949 (BUR2) , P23293 (SGV1) , P06242 (KIN28) , P37366 (CCL1) BioGRID 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1646 Phosphorylation P06242 (KIN28) , P37366 (CCL1) BioGRID 20835241, 19450536, 20818391, ...19679665
S1648 Phosphorylation Q03957 (CTK1) , P46962 (CTK2) BioGRID 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1651 Phosphorylation P23293 (SGV1) , Q05949 (BUR2) , P37366 (CCL1) , P06242 (KIN28) BioGRID 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1653 Phosphorylation P06242 (KIN28) , P37366 (CCL1) BioGRID 20835241, 19450536, 20818391, ...19679665
S1655 Phosphorylation Q03957 (CTK1) , P46962 (CTK2) BioGRID 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1658 Phosphorylation P37366 (CCL1) , Q05949 (BUR2) , P06242 (KIN28) , P23293 (SGV1) BioGRID 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1662 Phosphorylation P46962 (CTK2) , Q03957 (CTK1) BioGRID 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1665 Phosphorylation P37366 (CCL1) , P23293 (SGV1) , P06242 (KIN28) , Q05949 (BUR2) BioGRID 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1667 Phosphorylation P37366 (CCL1) , P06242 (KIN28) BioGRID 20835241, 19450536, 20818391, ...19679665
S1669 Phosphorylation Q03957 (CTK1) , P46962 (CTK2) BioGRID 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1672 Phosphorylation P37366 (CCL1) , P23293 (SGV1) , Q05949 (BUR2) , P06242 (KIN28) BioGRID 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1674 Phosphorylation P06242 (KIN28) , P37366 (CCL1) BioGRID 20835241, 19450536, 20818391, ...19679665
S1676 Phosphorylation Q03957 (CTK1) , P46962 (CTK2) BioGRID 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1679 Phosphorylation P06242 (KIN28) , P37366 (CCL1) , Q05949 (BUR2) , P23293 (SGV1) BioGRID 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1681 Phosphorylation P37366 (CCL1) , P06242 (KIN28) BioGRID 20835241, 19450536, 20818391, ...19679665
S1683 Phosphorylation Q03957 (CTK1) , P46962 (CTK2) BioGRID 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1686 Phosphorylation P37366 (CCL1) , Q05949 (BUR2) , P23293 (SGV1) , P06242 (KIN28) BioGRID 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1688 Phosphorylation P06242 (KIN28) , P37366 (CCL1) BioGRID 20835241, 19450536, 20818391, ...19679665
S1690 Phosphorylation P46962 (CTK2) , Q03957 (CTK1) BioGRID 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1693 Phosphorylation P06242 (KIN28) , P37366 (CCL1) , P23293 (SGV1) , Q05949 (BUR2) BioGRID 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1697 Phosphorylation P46962 (CTK2) , Q03957 (CTK1) BioGRID 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1700 Phosphorylation P06242 (KIN28) , Q05949 (BUR2) , P37366 (CCL1) , P23293 (SGV1) BioGRID 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1702 Phosphorylation P37366 (CCL1) , P06242 (KIN28) BioGRID 20835241, 19450536, 20818391, ...19679665
S1704 Phosphorylation Q03957 (CTK1) , P46962 (CTK2) BioGRID 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1707 Phosphorylation P37366 (CCL1) , Q05949 (BUR2) , P06242 (KIN28) , P23293 (SGV1) BioGRID 11018013, 10594013, 12972617, ...20818391, 9237170, 11390638
S1711 Phosphorylation Q03957 (CTK1) , P46962 (CTK2) BioGRID 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
S1714 Phosphorylation P06242 (KIN28) , P23293 (SGV1) , Q05949 (BUR2) , P37366 (CCL1) BioGRID   SGD 11018013, 10594013, 12972617, ...9237170, 20818391, 11390638, 33491328
S1718 Phosphorylation Q03957 (CTK1) , P46962 (CTK2) BioGRID 11018013, 10594013, 12972617, ...9237170, 11751637, 20818391
K1725 Ubiquitination SGD 30489083
S1732 Phosphorylation SGD 32597660, 33491328


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P04050 (RPO21) T1471 P23615 (SPT6) increased_association eFIP 28826505