Protein Information

Cytoscape View

UniProt AC / UniProt ID P04040 / CATA_HUMAN
Protein Name Catalase
Gene Name Name: CAT
Organism Homo sapiens (Human)

PRO ID PR:P04040
DAG View
PRO Name catalase (human)
Definition A catalase that is encoded in the genome of human.
Short Label hCAT
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P04040 (CAT) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 25944712
S9 Phosphorylation PhosphoSitePlus   UniProt 24275569
K16 Ubiquitination PhosphoSitePlus
K23 Ubiquitination PhosphoSitePlus
K38 Acetylation PhosphoSitePlus
K38 Ubiquitination PhosphoSitePlus
R47 Methylation PhosphoSitePlus
K77 Ubiquitination PhosphoSitePlus
Y84 Phosphorylation PhosphoSitePlus
K93 Acetylation PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
T107 Phosphorylation PhosphoSitePlus
S114 O-Glycosylation GlyGen   PhosphoSitePlus 18984734, 26374642, 30397120
T115 Phosphorylation PhosphoSitePlus
T150 Phosphorylation PhosphoSitePlus
S167 Phosphorylation Q05655 (PRKCD) PhosphoSitePlus 24211614
Y231 Phosphorylation P42684 (ABL2) , A0A173G4P4 (Abl fusion) , P00519 (ABL1) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 29535798, 12777400, 18083107, ...12950161, 15890005
C232 S-Nitrosylation dbSNO 25040305
K233 Acetylation PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
K237 Acetylation PhosphoSitePlus
K237 Ubiquitination PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
N244 N-Glycosylation GlyGen 29391424
S254 O-Glycosylation GlyGen   PhosphoSitePlus 18984734, 26374642, 30397120
Y260 Phosphorylation PhosphoSitePlus
K306 Ubiquitination PhosphoSitePlus
Y308 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107
K315 Ubiquitination PhosphoSitePlus
Y358 Phosphorylation PhosphoSitePlus
Y370 Phosphorylation PhosphoSitePlus
Y379 Phosphorylation PhosphoSitePlus
Y386 Phosphorylation A0A173G4P4 (Abl fusion) , P42684 (ABL2) , P00519 (ABL1) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 29535798, 12950161, 15890005, ...12777400
S422 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y425 Phosphorylation PhosphoSitePlus
N439 N-Glycosylation GlyGen 29391424
Y447 Phosphorylation PhosphoSitePlus
C460 S-Nitrosylation dbSNO 24105792
K468 Acetylation PhosphoSitePlus
K468 Ubiquitination PhosphoSitePlus
K476 Acetylation PhosphoSitePlus
K480 Acetylation PhosphoSitePlus
K480 Ubiquitination PhosphoSitePlus
N481 N-Glycosylation GlyGen 29391424
K499 Ubiquitination PhosphoSitePlus
T511 Phosphorylation PhosphoSitePlus   UniProt 24275569
S515 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20166139, 23186163, 24275569
S517 Phosphorylation PhosphoSitePlus   UniProt 24275569

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O75381 (PEX14) S232 P04040 (CAT) inhibited_association eFIP 32831175

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 D2 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S9 I9 Biomuta DOID:363 / uterine cancer [ tcga ]
R47 G47 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
R47 H47 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
K243 E243 Biomuta DOID:363 / uterine cancer [ tcga ]
K476 N476 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]