Protein Information

Cytoscape View


UniProt AC / UniProt ID P04035 / HMDH_HUMAN
Protein Name 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Gene Name Name: HMGCR
Organism Homo sapiens (Human)

PRO ID PR:P04035
DAG View
PRO Name 3-hydroxy-3-methylglutaryl-coenzyme A reductase (human)
Definition A 3-hydroxy-3-methylglutaryl-coenzyme A reductase that is encoded in the genome of human.
Short Label hHMGCR
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P04035 (HMGCR) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K89 Ubiquitination UniProt 19458199
K142 Ubiquitination PhosphoSitePlus
K248 Ubiquitination PhosphoSitePlus   UniProt 19458199
S261 Phosphorylation PhosphoSitePlus
S278 Phosphorylation PhosphoSitePlus
N281 N-Glycosylation GlyGen 29741879, 24190977
T286 Phosphorylation PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
K299 Ubiquitination PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus
S356 Phosphorylation PhosphoSitePlus
K362 Ubiquitination PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus
K381 Ubiquitination PhosphoSitePlus
T389 Phosphorylation PhosphoSitePlus
K396 Ubiquitination PhosphoSitePlus
K401 Ubiquitination PhosphoSitePlus
T409 Phosphorylation PhosphoSitePlus
S420 Phosphorylation PhosphoSitePlus
T425 Phosphorylation PhosphoSitePlus
S427 Phosphorylation PhosphoSitePlus
T431 Phosphorylation PhosphoSitePlus
K457 Ubiquitination PhosphoSitePlus
K460 Ubiquitination PhosphoSitePlus
S463 Phosphorylation PhosphoSitePlus
K474 Ubiquitination PhosphoSitePlus
K480 Ubiquitination PhosphoSitePlus
K502 Ubiquitination PhosphoSitePlus
S504 Phosphorylation PhosphoSitePlus   UniProt 23186163
S602 Phosphorylation PhosphoSitePlus
K606 Ubiquitination PhosphoSitePlus
K619 Ubiquitination PhosphoSitePlus
K633 Ubiquitination PhosphoSitePlus
S637 Phosphorylation PhosphoSitePlus
Y644 Phosphorylation PhosphoSitePlus
K662 Ubiquitination PhosphoSitePlus
K666 Ubiquitination PhosphoSitePlus
K670 Ubiquitination PhosphoSitePlus
K692 Sumoylation PhosphoSitePlus
K692 Ubiquitination PhosphoSitePlus
K704 Ubiquitination PhosphoSitePlus
K715 Ubiquitination PhosphoSitePlus
K864 Ubiquitination PhosphoSitePlus
S872 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 2369897, 31904416, 24275569
K873 Ubiquitination PhosphoSitePlus
T884 Phosphorylation PhosphoSitePlus
K885 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S872 Phosphorylation P17612 (PRKACA) HPRD 2369897
Site PTM Type PTM Enzyme Score Source PMID
K502 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K362 N362 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K460 N460 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K480 N480 Biomuta DOID:3571 / liver cancer [ icgc ]
K502 N502 Biomuta DOID:3571 / liver cancer [ icgc ]
K619 Q619 Biomuta DOID:363 / uterine cancer [ tcga ]
K662 N662 Biomuta DOID:3571 / liver cancer [ icgc ]
K704 T704 Biomuta DOID:363 / uterine cancer [ tcga ]