iPTMnet Report for P03956 (MMP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P03956 / MMP1_HUMAN
Protein Name Interstitial collagenase precursor
Gene Name Name: MMP1
Synonyms:CLG;
Organism Homo sapiens (Human)

PRO ID PR:P03956
DAG View
PRO Name interstitial collagenase (human)
Definition An interstitial collagenase that is encoded in the genome of human.
Short Label hMMP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P03956 (MMP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S57 Phosphorylation PhosphoSitePlus   UniProt 25171405
N120 N-Glycosylation GlyGen 10092871
Y121 Phosphorylation PhosphoSitePlus
T122 Phosphorylation PhosphoSitePlus
S142 Phosphorylation PhosphoSitePlus
N143 N-Glycosylation GlyGen 23345538
S153 Phosphorylation PhosphoSitePlus
T274 Phosphorylation PhosphoSitePlus   UniProt 25171405
S280 Phosphorylation HPRD   PhosphoSitePlus 19413330
T288 Phosphorylation HPRD   PhosphoSitePlus 19413330
T289 Phosphorylation HPRD   PhosphoSitePlus 19413330
Y360 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20058876, 25171405
K450 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N120 N-Glycosylation PRO 10092871
N143 N-Glycosylation PRO 23345538


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T122 M122 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S142 C142 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
T274 I274 Biomuta DOID:4159 / skin cancer [ cosmic ]
T289 M289 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y360 H360 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]