iPTMnet Report for P03951 (F11)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P03951 / FA11_HUMAN
Protein Name Coagulation factor XI precursor
Gene Name Name: F11
Organism Homo sapiens (Human)

PRO ID PR:P03951
DAG View
PRO Name coagulation factor XI (human)
Definition A coagulation factor XI that is encoded in the genome of human.
Short Label hF11
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P03951 (F11) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S17 Phosphorylation PhosphoSitePlus
T22 Phosphorylation PhosphoSitePlus
N90 N-Glycosylation GlyGen   UniProt 25092234
Y115 Phosphorylation PhosphoSitePlus
Y125 Phosphorylation PhosphoSitePlus
N126 N-Glycosylation GlyGen   UniProt 16335952, 23090970, 29741879, ...29391424, 25092234
S128 Phosphorylation PhosphoSitePlus
N163 N-Glycosylation GlyGen   UniProt 29391424, 25092234
K180 Acetylation PhosphoSitePlus
S186 Phosphorylation PhosphoSitePlus
S394 Phosphorylation PhosphoSitePlus
N450 N-Glycosylation GlyGen   UniProt 16335952, 19159218, 24190977, ...23090970, 25092234, 29391424, 29741879
N491 N-Glycosylation GlyGen   UniProt 16335952, 19159218, 25092234, ...23090970, 29391424, 29741879, 29671580, 1998667
T517 Phosphorylation PhosphoSitePlus
Y521 Phosphorylation PhosphoSitePlus
Y608 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y115 Phosphorylation HPRD 18491316
Y125 Phosphorylation HPRD 18491316
S128 Phosphorylation HPRD 18491316
N491 N-Glycosylation PRO 29671580, 25092234


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S17 P17 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S394 P394 Biomuta DOID:1324 / lung cancer [ cosmic ]
S394 Y394 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S394 F394 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
Y608 H608 Biomuta DOID:4159 / skin cancer [ cosmic ]