iPTMnet Report for P02788 (LTF)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P02788 / TRFL_HUMAN
Protein Name Lactotransferrin precursor
Gene Name Name: LTF
Synonyms:GIG12,LF;
Organism Homo sapiens (Human)

PRO ID PR:P02788
DAG View
PRO Name lactotransferrin (human)
Definition A lactotransferrin that is encoded in the genome of human.
Short Label hLTF
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P02788 (LTF) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
F10 Phosphorylation UniProt 20404350
S24 Phosphorylation PhosphoSitePlus
S54 O-Glycosylation PhosphoSitePlus
S54 Phosphorylation PhosphoSitePlus
K57 Sumoylation PhosphoSitePlus
T109 Phosphorylation IEDB 35494241
Y111 Phosphorylation PhosphoSitePlus
Y112 Phosphorylation PhosphoSitePlus
N156 N-Glycosylation GlyGen   UniProt 32125861, 7774715, 29741879, ...15299444, 23662732, 26791533, 1581307, 2390069, 15299793, 16201406, 18780401, 8069634, 7068558, 12151713
Y211 Phosphorylation PhosphoSitePlus
K216 Acetylation PhosphoSitePlus
K256 Acetylation PhosphoSitePlus
K260 Acetylation PhosphoSitePlus
K262 Acetylation PhosphoSitePlus
S278 Phosphorylation PhosphoSitePlus
K320 Acetylation PhosphoSitePlus
S327 Phosphorylation PhosphoSitePlus
K352 Sumoylation PhosphoSitePlus
Q379 Ubiquitination UniProt 20404350
S391 Ubiquitination UniProt 20404350
K405 Sumoylation PhosphoSitePlus
K423 Sumoylation PhosphoSitePlus
K423 Ubiquitination PhosphoSitePlus
K435 Acetylation PhosphoSitePlus
K435 Sumoylation PhosphoSitePlus
S436 O-Glycosylation GlyGen 30237853
Y454 Phosphorylation PhosphoSitePlus
S477 Phosphorylation PhosphoSitePlus
T480 Phosphorylation PhosphoSitePlus
T485 Phosphorylation PhosphoSitePlus
N497 N-Glycosylation GlyGen   UniProt 30237853, 19159218, 7774715, ...23662732, 26791533, 1581307, 32125861, 2390069, 15299793, 16201406, 18780401, 29741879, 7068558, 12151713
T499 Phosphorylation PhosphoSitePlus
S501 Phosphorylation PhosphoSitePlus
S540 Phosphorylation PhosphoSitePlus
Y545 Phosphorylation PhosphoSitePlus
Y547 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
K565 Acetylation PhosphoSitePlus
T603 Phosphorylation PhosphoSitePlus
S607 Phosphorylation PhosphoSitePlus
C608 S-Nitrosylation dbSNO 25040305
S620 Phosphorylation PhosphoSitePlus
N642 N-Glycosylation GlyGen   UniProt 23662732, 32125861, 18780401
Site PTM Type PTM Enzyme Score Source PMID
N156 N-Glycosylation PRO 26791533, 2390069, 12151713, ...7068558, 7774715
S278 Phosphorylation HPRD 20058876
N497 N-Glycosylation PRO 26791533, 2390069, 12151713, ...7068558, 7774715


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y111 C111 Biomuta DOID:1324 / lung cancer [ cosmic ]
N156 H156 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S278 N278 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S327 L327 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T485 N485 Biomuta DOID:3571 / liver cancer [ cosmic ]
S501 Y501 Biomuta DOID:1324 / lung cancer [ cosmic ]
S501 A501 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S540 T540 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S540 N540 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K565 R565 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]