Protein Information

Cytoscape View


UniProt AC / UniProt ID P02787 / TRFE_HUMAN
Protein Name Serotransferrin precursor
Gene Name Name: TF
ORFNames:PRO1400;
Organism Homo sapiens (Human)

PRO ID PR:P02787
DAG View
PRO Name serotransferrin (human)
Definition A serotransferrin that is encoded in the genome of human.
Short Label hTF
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P02787 (TF) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T36 Phosphorylation PhosphoSitePlus
K37 Acetylation PhosphoSitePlus
C58 S-Nitrosylation dbSNO 25040305
S63 Phosphorylation PhosphoSitePlus
Y64 Phosphorylation PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
C137 S-Nitrosylation dbSNO 25040305
T139 Phosphorylation PhosphoSitePlus
S144 Phosphorylation PhosphoSitePlus
Y155 Phosphorylation PhosphoSitePlus
Y207 Phosphorylation PhosphoSitePlus
C213 S-Nitrosylation dbSNO 25040305
C246 S-Nitrosylation dbSNO 25040305
Y257 Phosphorylation PhosphoSitePlus
C260 S-Nitrosylation dbSNO 25040305
S298 Phosphorylation PhosphoSitePlus
S305 Phosphorylation PhosphoSitePlus
S306 Phosphorylation PhosphoSitePlus
T340 Phosphorylation PhosphoSitePlus
T349 Phosphorylation PhosphoSitePlus
T355 Phosphorylation PhosphoSitePlus
K359 Acetylation PhosphoSitePlus
C364 S-Nitrosylation dbSNO 25040305
C374 S-Nitrosylation dbSNO 25040305
S389 Phosphorylation PhosphoSitePlus   UniProt 26091039
C396 S-Nitrosylation dbSNO 25040305
S409 O-Glycosylation GlyGen 30459171
N432 N-Glycosylation GlyGen 10029548, 14760718, 1456441, ...8174273, 25153361, 29741879, 16335952, 24530628, 32125861, 26791533, 19838169, 22327295, 29992770, 19159218, 24190977, 24780636, 7944531, 15084671, 24841998, 18514042, 10929010, 30237853, 23090970, 15536627, 25425657, 29671580
S468 Phosphorylation PhosphoSitePlus
T476 Phosphorylation PhosphoSitePlus
N491 N-Glycosylation GlyGen   UniProt 15474009, 23090970, 15536627
C503 S-Nitrosylation dbSNO 25040305
K508 Acetylation PhosphoSitePlus
S520 Phosphorylation PhosphoSitePlus
N523 N-Glycosylation GlyGen 23090970, 29391424
C525 S-Nitrosylation dbSNO 25040305
Y533 Phosphorylation PhosphoSitePlus
Y534 Phosphorylation PhosphoSitePlus
Y536 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107
T537 Phosphorylation PhosphoSitePlus
K546 Acetylation PhosphoSitePlus
C582 S-Nitrosylation dbSNO 25040305
Y593 Phosphorylation PhosphoSitePlus
C596 S-Nitrosylation dbSNO 25040305
N630 N-Glycosylation GlyGen 10029548, 14760718, 29391424, ...1456441, 8174273, 25153361, 29741879, 16335952, 24530628, 32125861, 26791533, 19139490, 19838169, 16740002, 10929010, 29992770, 29427759, 19159218, 24190977, 24780636, 7944531, 15084671, 24841998, 18514042, 22327295, 30237853, 23090970, 15536627, 25425657, 29671580, 24417605
N637 N-Glycosylation GlyGen 26791533
T645 Phosphorylation PhosphoSitePlus
T654 Phosphorylation PhosphoSitePlus
Y666 Phosphorylation PhosphoSitePlus
Y669 Phosphorylation PhosphoSitePlus
Y674 Phosphorylation PhosphoSitePlus
C684 S-Nitrosylation dbSNO 25040305
S685 Phosphorylation PhosphoSitePlus   UniProt 26091039
T686 Phosphorylation PhosphoSitePlus
S688 Phosphorylation PhosphoSitePlus
T694 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K37 M37 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K37 E37 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
Y207 * Biomuta DOID:363 / uterine cancer [ tcga ]
C246 Y246 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T340 S340 Biomuta DOID:1324 / lung cancer [ tcga ]
T349 K349 Biomuta DOID:1324 / lung cancer [ tcga ]
C503 F503 Biomuta DOID:3571 / liver cancer [ icgc ]
C582 F582 Biomuta DOID:3571 / liver cancer [ icgc ]
T654 R654 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
Y669 * Biomuta DOID:9256 / colorectal cancer [ icgc ]
C684 * Biomuta DOID:1324 / lung cancer [ cosmic ]
C684 F684 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
C684 Y684 Biomuta DOID:363 / uterine cancer [ tcga ]