Protein Information

Cytoscape View


UniProt AC / UniProt ID P02786 / TFR1_HUMAN
Protein Name Transferrin receptor protein 1
Gene Name Name: TFRC
Organism Homo sapiens (Human)

PRO ID PR:P02786
DAG View
PRO Name transferrin receptor protein 1 (human)
Definition A transferrin receptor protein 1 that is encoded in the genome of human.
Short Label hTFRC
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P02786 (TFRC) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation PhosphoSitePlus
S10 Phosphorylation PhosphoSitePlus   UniProt 23186163
S19 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
Y20 Phosphorylation P12931 (SRC) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19901323, 17389395, 21859709, ...15951569, 18669648, 18707149, 15592455, 20068231, 16497976
T21 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
S24 Phosphorylation P17252 (PRKCA) HPRD   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 3479328, 3013873, 18669648, ...3119581, 9782058, 20068231
S34 Phosphorylation HPRD   PhosphoSitePlus 20068231
K39 Ubiquitination PhosphoSitePlus
T52 Phosphorylation PhosphoSitePlus
K53 Acetylation PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
T104 O-Glycosylation PhosphoSitePlus
S106 Phosphorylation PhosphoSitePlus
Y123 Phosphorylation PhosphoSitePlus
K128 Acetylation PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
K134 Ubiquitination PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
Y168 Phosphorylation PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
S195 Phosphorylation PhosphoSitePlus
S199 Phosphorylation PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
Y219 Phosphorylation PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
N251 N-Glycosylation UniProt 16335952, 10531064, 19159218, ...19349973
K261 Ubiquitination PhosphoSitePlus
Y282 Phosphorylation PhosphoSitePlus
T286 Phosphorylation PhosphoSitePlus
N317 N-Glycosylation UniProt 10531064
S326 Phosphorylation PhosphoSitePlus
S327 Phosphorylation PhosphoSitePlus
S338 Phosphorylation PhosphoSitePlus
K344 Ubiquitination PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus
K371 Ubiquitination PhosphoSitePlus
K374 Ubiquitination PhosphoSitePlus
K382 Ubiquitination PhosphoSitePlus
K385 Ubiquitination PhosphoSitePlus
K394 Acetylation PhosphoSitePlus
Y402 Phosphorylation PhosphoSitePlus
K418 Acetylation PhosphoSitePlus
K418 Ubiquitination PhosphoSitePlus
S419 Phosphorylation PhosphoSitePlus
Y481 Phosphorylation PhosphoSitePlus
K486 Ubiquitination PhosphoSitePlus
S499 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y503 Phosphorylation HPRD   PhosphoSitePlus 20068231
K508 Ubiquitination PhosphoSitePlus
K514 Ubiquitination PhosphoSitePlus
Y523 Phosphorylation PhosphoSitePlus
K531 Ubiquitination PhosphoSitePlus
T572 Phosphorylation PhosphoSitePlus
Y573 Phosphorylation PhosphoSitePlus
K585 Ubiquitination PhosphoSitePlus
Y611 Phosphorylation PhosphoSitePlus
S616 Phosphorylation PhosphoSitePlus
S620 Phosphorylation PhosphoSitePlus
T658 Phosphorylation HPRD   PhosphoSitePlus 17081983
K665 Ubiquitination PhosphoSitePlus
Y683 Phosphorylation PhosphoSitePlus
S687 Phosphorylation PhosphoSitePlus
S691 Phosphorylation PhosphoSitePlus
K693 Ubiquitination PhosphoSitePlus
K717 Ubiquitination PhosphoSitePlus
K720 Ubiquitination PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000045518 (hTFRC/Phos:1) pS24 PRO 3013873, 3119581


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S19 L19 Biomuta DOID:1324 / lung cancer [ cosmic ]
T21 A21 Biomuta DOID:363 / uterine cancer [ tcga ]
K145 N145 Biomuta DOID:11934 / head and neck cancer [ tcga ]
Y282 S282 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
N317 S317 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S338 F338 Biomuta DOID:1909 / melanoma [ icgc ]
S338 C338 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S419 F419 Biomuta DOID:1909 / melanoma [ tcga ]
S499 N499 Biomuta DOID:363 / uterine cancer [ tcga ]
T658 R658 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]