iPTMnet Report for P02786 (TFRC)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P02786 / TFR1_HUMAN
Protein Name Transferrin receptor protein 1
Gene Name Name: TFRC
Organism Homo sapiens (Human)

PRO ID PR:P02786
DAG View
PRO Name transferrin receptor protein 1 (human)
Definition A transferrin receptor protein 1 that is encoded in the genome of human.
Short Label hTFRC
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P02786 (TFRC) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation PhosphoSitePlus
S10 Phosphorylation PhosphoSitePlus   UniProt 23186163
S19 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
Y20 Phosphorylation P12931 (SRC) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19901323, 17389395, 21859709, ...15951569, 18669648, 35338344, 18707149, 15592455, 20068231, 16497976
T21 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
S24 Phosphorylation P17252 (PRKCA) HPRD   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 3479328, 3013873, 18669648, ...3119581, 9782058, 20068231
S34 Phosphorylation HPRD   PhosphoSitePlus 20068231
K39 Ubiquitination PhosphoSitePlus
N50 N-Glycosylation GlyGen 29391424
T52 Phosphorylation PhosphoSitePlus
K53 Acetylation PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
N55 N-Glycosylation GlyGen 29391424
K58 Ubiquitination PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
T104 O-Glycosylation GlyGen   PhosphoSitePlus 2403553, 33214551, 1421756, ...30397120, 1421757, 30459171, 34725712, 25813380, 34019948, 35254053, 35132862, 33465208, 35008409, 23584533, 32119511, 21300897, 35083852, 7780197, 22661428
S106 O-Glycosylation GlyGen 35008409, 33214551, 30397120, ...34725712, 34019948, 35254053, 35132862, 35083852, 33465208, 32119511, 21300897, 22661428
S106 Phosphorylation PhosphoSitePlus
Y123 Phosphorylation PhosphoSitePlus
K128 Acetylation PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
K134 Ubiquitination PhosphoSitePlus
K145 Acetylation IEDB 34357683
K145 Ubiquitination PhosphoSitePlus
N148 N-Glycosylation GlyGen 24190977
K161 Ubiquitination PhosphoSitePlus
Y168 Phosphorylation PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
S195 Phosphorylation PhosphoSitePlus
S199 Phosphorylation PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
Y219 Phosphorylation PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
N251 N-Glycosylation GlyGen   UniProt 16335952, 19159218, 24190977, ...23090970, 29391424, 19349973, 16716077, 29741879, 10531064, 9136890
K261 Ubiquitination PhosphoSitePlus
Y282 Phosphorylation PhosphoSitePlus
T286 Phosphorylation PhosphoSitePlus
N317 N-Glycosylation GlyGen   UniProt 16716077, 10531064, 9136890
S326 Phosphorylation PhosphoSitePlus
S327 Phosphorylation PhosphoSitePlus
S338 Phosphorylation PhosphoSitePlus
K344 Ubiquitination PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus
K371 Ubiquitination PhosphoSitePlus
K374 Ubiquitination PhosphoSitePlus
K382 Ubiquitination PhosphoSitePlus
K385 Ubiquitination PhosphoSitePlus
K394 Acetylation PhosphoSitePlus
Y402 Phosphorylation PhosphoSitePlus
K418 Acetylation PhosphoSitePlus
K418 Ubiquitination PhosphoSitePlus
S419 Phosphorylation PhosphoSitePlus
Y481 Phosphorylation PhosphoSitePlus
K486 Ubiquitination PhosphoSitePlus
S492 O-Glycosylation GlyGen 35008409, 33214551, 30397120, ...34725712, 34019948, 35254053, 35132862, 35083852, 33465208, 32119511, 21300897, 22661428
S499 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y503 Phosphorylation HPRD   PhosphoSitePlus 20068231
K508 Ubiquitination PhosphoSitePlus
K514 Ubiquitination PhosphoSitePlus
Y523 Phosphorylation PhosphoSitePlus
K531 Ubiquitination PhosphoSitePlus
T572 Phosphorylation PhosphoSitePlus
Y573 Phosphorylation PhosphoSitePlus
K585 Ubiquitination PhosphoSitePlus
Y611 Phosphorylation PhosphoSitePlus
N615 N-Glycosylation GlyGen 24190977
S616 Phosphorylation PhosphoSitePlus
S620 Phosphorylation PhosphoSitePlus
T658 Phosphorylation HPRD   PhosphoSitePlus 17081983
K665 Ubiquitination PhosphoSitePlus
Y683 Phosphorylation PhosphoSitePlus
S687 O-Glycosylation GlyGen 35008409, 33214551, 30397120, ...34725712, 34019948, 35254053, 35132862, 35083852, 33465208, 32119511, 21300897, 22661428
S687 Phosphorylation PhosphoSitePlus
S691 Phosphorylation PhosphoSitePlus
K693 Ubiquitination PhosphoSitePlus
K717 Ubiquitination PhosphoSitePlus
K720 Ubiquitination PhosphoSitePlus
N722 N-Glycosylation GlyGen 29391424
N727 N-Glycosylation GlyGen 34089345, 2403553, 19159218, ...24190977, 23090970, 1421757, 9136890, 16716077, 29741879, 10531064, 7780197
T729 O-Glycosylation GlyGen 35008409, 33214551, 30397120, ...34725712, 34019948, 35254053, 35132862, 35083852, 33465208, 32119511, 21300897, 22661428
Site PTM Type PTM Enzyme Score Source PMID
N251 N-Glycosylation PRO 9136890
N317 N-Glycosylation PRO 9136890
N727 N-Glycosylation PRO 2403553, 1421757, 7780197


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000045518 (hTFRC/Phos:1) pS24 PRO 3013873, 3119581


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S19 L19 Biomuta DOID:1324 / lung cancer [ cosmic ]
T21 A21 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
N55 S55 Biomuta [ cosmic ]
K145 N145 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S199 L199 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y282 S282 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
N317 I317 Biomuta DOID:3571 / liver cancer [ cosmic ]
N317 S317 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S326 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S338 F338 Biomuta DOID:4159 / skin cancer [ icgc ]
S338 C338 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S419 F419 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S499 N499 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y611 C611 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
N615 S615 Biomuta DOID:1324 / lung cancer [ cosmic ]
T658 R658 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K693 R693 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K720 Q720 Biomuta DOID:10534 / stomach cancer [ cosmic ]
N722 S722 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T729 M729 Biomuta DOID:10534 / stomach cancer [ cosmic ]