iPTMnet Report P02786 TFRC

Protein Information

UniProt AC / UniProt ID	P02786 / TFR1_HUMAN
Protein Name	Transferrin receptor protein 1
Gene Name	Name: TFRC
Organism	Homo sapiens (Human)

PRO ID	PR:P02786 DAG View
PRO Name	transferrin receptor protein 1 (human)
Definition	A transferrin receptor protein 1 that is encoded in the genome of human.
Short Label	hTFRC
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P02786 (TFRC) as Substrate

Expanded View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position S7 S10 S19 Y20 T21 S24 S34 K39 N50 T52 K53 N55 K58 K60 T104 S106 Y123 K128 K134 K145 N148 K161 Y168 K177 K189 K193 S195 S199 K205 Y219 K224 K231 K240 K241 N251 K261 Y282 T286 N317 S326 S327 S338 K344 K358 K371 K374 K382 K385 K394 Y402 K418 S419 Y481 K486 S492 S499 Y503 K508 K514 Y523 K531 T572 Y573 K585 Y611 N615 S616 S620 T658 K665 Y683 S687 S691 K693 K717 K720 N722 N727 T729	PTM Type Select all Acetylation N-Glycosylation O-Glycosylation Phosphorylation Ubiquitination	PTM Enzyme	Score Select all 1 2 3 4	Source Select all GlyGen HPRD IEDB PRO PhosphoSitePlus RLIMS-P UniProt phospho.ELM	PMID
S7	Phosphorylation		score1	PhosphoSitePlus
S10	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
S19	Phosphorylation		score2	HPRD phospho.ELM PhosphoSitePlus	18669648
Y20	Phosphorylation	P12931 (SRC)	score4	HPRD phospho.ELM PhosphoSitePlus RLIMS-P UniProt	19901323, 17389395, 21859709, ...15951569, 18669648, 35338344, 18707149, 15592455, 20068231, 16497976
T21	Phosphorylation		score2	HPRD phospho.ELM PhosphoSitePlus UniProt	18669648
S24	Phosphorylation	P17252 (PRKCA)	score4	HPRD phospho.ELM PRO PhosphoSitePlus RLIMS-P UniProt	3479328, 3013873, 18669648, ...3119581, 9782058, 20068231
S34	Phosphorylation		score2	HPRD PhosphoSitePlus	20068231
K39	Ubiquitination		score1	PhosphoSitePlus
N50	N-Glycosylation		score1	GlyGen	29391424
T52	Phosphorylation		score1	PhosphoSitePlus
K53	Acetylation		score1	PhosphoSitePlus
K53	Ubiquitination		score1	PhosphoSitePlus
N55	N-Glycosylation		score1	GlyGen	29391424
K58	Ubiquitination		score1	PhosphoSitePlus
K60	Ubiquitination		score1	PhosphoSitePlus
T104	O-Glycosylation		score4	GlyGen PhosphoSitePlus	2403553, 33214551, 1421756, ...30397120, 1421757, 30459171, 34725712, 25813380, 34019948, 35254053, 35132862, 33465208, 35008409, 23584533, 32119511, 21300897, 35083852, 7780197, 22661428
S106	O-Glycosylation		score1	GlyGen	35008409, 33214551, 30397120, ...34725712, 34019948, 35254053, 35132862, 35083852, 33465208, 32119511, 21300897, 22661428
S106	Phosphorylation		score1	PhosphoSitePlus
Y123	Phosphorylation		score1	PhosphoSitePlus
K128	Acetylation		score1	PhosphoSitePlus
K128	Ubiquitination		score1	PhosphoSitePlus
K134	Ubiquitination		score1	PhosphoSitePlus
K145	Acetylation		score1	IEDB	34357683
K145	Ubiquitination		score1	PhosphoSitePlus
N148	N-Glycosylation		score1	GlyGen	24190977
K161	Ubiquitination		score1	PhosphoSitePlus
Y168	Phosphorylation		score1	PhosphoSitePlus
K177	Ubiquitination		score1	PhosphoSitePlus
K189	Ubiquitination		score1	PhosphoSitePlus
K193	Ubiquitination		score1	PhosphoSitePlus
S195	Phosphorylation		score1	PhosphoSitePlus
S199	Phosphorylation		score1	PhosphoSitePlus
K205	Ubiquitination		score1	PhosphoSitePlus
Y219	Phosphorylation		score1	PhosphoSitePlus
K224	Ubiquitination		score1	PhosphoSitePlus
K231	Ubiquitination		score1	PhosphoSitePlus
K240	Ubiquitination		score1	PhosphoSitePlus
K241	Ubiquitination		score1	PhosphoSitePlus
N251	N-Glycosylation		score4	GlyGen UniProt	16335952, 19159218, 24190977, ...23090970, 29391424, 19349973, 16716077, 29741879, 10531064, 9136890
K261	Ubiquitination		score1	PhosphoSitePlus
Y282	Phosphorylation		score1	PhosphoSitePlus
T286	Phosphorylation		score1	PhosphoSitePlus
N317	N-Glycosylation		score4	GlyGen UniProt	16716077, 10531064, 9136890
S326	Phosphorylation		score1	PhosphoSitePlus
S327	Phosphorylation		score1	PhosphoSitePlus
S338	Phosphorylation		score1	PhosphoSitePlus
K344	Ubiquitination		score1	PhosphoSitePlus
K358	Ubiquitination		score1	PhosphoSitePlus
K371	Ubiquitination		score1	PhosphoSitePlus
K374	Ubiquitination		score1	PhosphoSitePlus
K382	Ubiquitination		score1	PhosphoSitePlus
K385	Ubiquitination		score1	PhosphoSitePlus
K394	Acetylation		score1	PhosphoSitePlus
Y402	Phosphorylation		score1	PhosphoSitePlus
K418	Acetylation		score1	PhosphoSitePlus
K418	Ubiquitination		score1	PhosphoSitePlus
S419	Phosphorylation		score1	PhosphoSitePlus
Y481	Phosphorylation		score1	PhosphoSitePlus
K486	Ubiquitination		score1	PhosphoSitePlus
S492	O-Glycosylation		score1	GlyGen	35008409, 33214551, 30397120, ...34725712, 34019948, 35254053, 35132862, 35083852, 33465208, 32119511, 21300897, 22661428
S499	Phosphorylation		score2	HPRD PhosphoSitePlus	20068231
Y503	Phosphorylation		score2	HPRD PhosphoSitePlus	20068231
K508	Ubiquitination		score1	PhosphoSitePlus
K514	Ubiquitination		score1	PhosphoSitePlus
Y523	Phosphorylation		score1	PhosphoSitePlus
K531	Ubiquitination		score1	PhosphoSitePlus
T572	Phosphorylation		score1	PhosphoSitePlus
Y573	Phosphorylation		score1	PhosphoSitePlus
K585	Ubiquitination		score1	PhosphoSitePlus
Y611	Phosphorylation		score1	PhosphoSitePlus
N615	N-Glycosylation		score1	GlyGen	24190977
S616	Phosphorylation		score1	PhosphoSitePlus
S620	Phosphorylation		score1	PhosphoSitePlus
T658	Phosphorylation		score2	HPRD PhosphoSitePlus	17081983
K665	Ubiquitination		score1	PhosphoSitePlus
Y683	Phosphorylation		score1	PhosphoSitePlus
S687	O-Glycosylation		score1	GlyGen	35008409, 33214551, 30397120, ...34725712, 34019948, 35254053, 35132862, 35083852, 33465208, 32119511, 21300897, 22661428
S687	Phosphorylation		score1	PhosphoSitePlus
S691	Phosphorylation		score1	PhosphoSitePlus
K693	Ubiquitination		score1	PhosphoSitePlus
K717	Ubiquitination		score1	PhosphoSitePlus
K720	Ubiquitination		score1	PhosphoSitePlus
N722	N-Glycosylation		score1	GlyGen	29391424
N727	N-Glycosylation		score3	GlyGen	34089345, 2403553, 19159218, ...24190977, 23090970, 1421757, 9136890, 16716077, 29741879, 10531064, 7780197
T729	O-Glycosylation		score1	GlyGen	35008409, 33214551, 30397120, ...34725712, 34019948, 35254053, 35132862, 35083852, 33465208, 32119511, 21300897, 22661428

Search:

Site Select all By amino acid By position N251 N317 N727	PTM Type Select all N-Glycosylation	Score Select all 2 3	Source Select all PRO	PMID
N251	N-Glycosylation	score2	PRO	9136890
N317	N-Glycosylation	score2	PRO	9136890
N727	N-Glycosylation	score3	PRO	2403553, 1421757, 7780197

Proteoforms

Search:

	PRO ID (Short Label) Select all PR:000045518 (hTFRC/Phos:1)	Sites Select all pS24	PTM Enzyme	Source Select all PRO	PMID
	PR:000045518 (hTFRC/Phos:1)	pS24		PRO	3013873, 3119581

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position S19 T21 N55 K145 S199 Y282 N317 S326 S338 S419 S499 Y611 N615 T658 K693 K720 N722 T729	Variant Select all * A21 C338 C611 F338 F419 I317 L19 L199 M729 N145 N499 Q720 R658 R693 S282 S317 S55 S615 S722	Source Select all Biomuta	Disease [Sample source] Select all DOID:10534 / stomach cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:2394 / ovarian cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ] [ cosmic ]
S19	L19	Biomuta	DOID:1324 / lung cancer [ cosmic ]
T21	A21	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
N55	S55	Biomuta	[ cosmic ]
K145	N145	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S199	L199	Biomuta	DOID:4159 / skin cancer [ cosmic ]
Y282	S282	Biomuta	DOID:1612 / breast cancer [ cosmic, icgc ]
N317	I317	Biomuta	DOID:3571 / liver cancer [ cosmic ]
N317	S317	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S326	*	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S338	F338	Biomuta	DOID:4159 / skin cancer [ icgc ]
S338	C338	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
S419	F419	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
S499	N499	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
Y611	C611	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
N615	S615	Biomuta	DOID:1324 / lung cancer [ cosmic ]
T658	R658	Biomuta	DOID:2394 / ovarian cancer [ cosmic, icgc ]
K693	R693	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
K720	Q720	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
N722	S722	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
T729	M729	Biomuta	DOID:10534 / stomach cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P02786 (TFRC)

Protein Information

Interactive Sequence View

P02786 (TFRC) as Substrate

Proteoforms

PTM sites affected in variants