iPTMnet Report for P02771 (AFP)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P02771 / FETA_HUMAN
Protein Name Alpha-fetoprotein precursor
Gene Name Name: AFP
Synonyms:HPAFP;
Organism Homo sapiens (Human)

PRO ID PR:P02771
DAG View
PRO Name alpha-fetoprotein (human)
Definition An alpha-fetoprotein that is encoded in the genome of human.
Short Label hAFP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P02771 (AFP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S111 Phosphorylation UniProt 26091039
S115 Phosphorylation UniProt 26091039
S117 Phosphorylation UniProt 26091039
K194 Acetylation PhosphoSitePlus
N197 N-Glycosylation GlyGen 23345538
K211 Acetylation PhosphoSitePlus
K228 Acetylation PhosphoSitePlus
K242 Acetylation PhosphoSitePlus
T248 Phosphorylation PhosphoSitePlus
N251 N-Glycosylation GlyGen 6192908, 7679920, 1694115, ...7686446, 7511099
S344 Phosphorylation UniProt 26091039
S368 Phosphorylation PhosphoSitePlus
Y377 Phosphorylation PhosphoSitePlus
Y404 Phosphorylation PhosphoSitePlus
S408 Phosphorylation PhosphoSitePlus
K413 Acetylation PhosphoSitePlus
S415 Phosphorylation PhosphoSitePlus
S444 Phosphorylation UniProt 26091039
S445 Phosphorylation UniProt 26091039
Site PTM Type PTM Enzyme Score Source PMID
N251 N-Glycosylation PRO 6192908, 7679920, 1694115, ...7686446


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K242 R242 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K242 N242 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S368 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S445 P445 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]