iPTMnet Report for P02751 (FN1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P02751 / FINC_HUMAN
Protein Name Fibronectin precursor
Gene Name Name: FN1
Synonyms:FN;
Organism Homo sapiens (Human)

PRO ID PR:P02751
DAG View
PRO Name fibronectin (human)
Definition A fibronectin that is encoded in the genome of human.
Short Label hFN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P02751 (FN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S41 O-Glycosylation GlyGen 30459171
S41 Phosphorylation PhosphoSitePlus
Y101 Phosphorylation PhosphoSitePlus
Y106 Phosphorylation PhosphoSitePlus
Y112 Phosphorylation PhosphoSitePlus
T136 Phosphorylation PhosphoSitePlus
N139 N-Glycosylation GlyGen 23090970, 24190977
T278 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171
T279 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 16037490, 30459171, 23584533
S280 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171
S281 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171
S283 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T287 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
Y372 Phosphorylation PhosphoSitePlus
N427 N-Glycosylation GlyGen 24190977
N428 N-Glycosylation GlyGen 24190977
N430 N-Glycosylation GlyGen   UniProt 16335952, 24190977, 16037490, ...11285216, 23090970, 29741879
K486 Methylation PhosphoSitePlus
N528 N-Glycosylation GlyGen   UniProt 16335952, 30237853, 19159218, ...24190977, 16037490, 26791533, 14760718, 23090970, 19139490, 24279413, 29741879, 29671580
N542 N-Glycosylation GlyGen   UniProt 16335952, 32125861, 24190977, ...16037490, 26791533, 23090970, 19139490, 24279413, 29741879, 29671580
Y588 Phosphorylation PhosphoSitePlus
T617 O-Glycosylation GlyGen 30459171
Y641 Phosphorylation PhosphoSitePlus
T715 Phosphorylation PhosphoSitePlus
T771 O-Glycosylation GlyGen 30459171
T818 O-Glycosylation GlyGen 30459171
N877 N-Glycosylation GlyGen   UniProt 16037490, 17614963
S904 Phosphorylation PhosphoSitePlus
Y937 Phosphorylation PhosphoSitePlus
T960 Phosphorylation PhosphoSitePlus
S968 Phosphorylation PhosphoSitePlus
T972 Phosphorylation PhosphoSitePlus
K987 Acetylation PhosphoSitePlus
N1007 N-Glycosylation GlyGen   UniProt 16335952, 30237853, 19159218, ...24190977, 16037490, 26791533, 23090970, 19139490, 24279413, 29741879, 29671580
Y1042 Phosphorylation PhosphoSitePlus
K1050 Ubiquitination PhosphoSitePlus
S1122 Phosphorylation PhosphoSitePlus
Y1206 Phosphorylation PhosphoSitePlus
N1236 N-Glycosylation GlyGen 29741879
N1244 N-Glycosylation GlyGen   UniProt 16037490, 16335952, 23090970, ...24190977
N1291 N-Glycosylation GlyGen 23090970, 29741879, 24190977
T1367 O-Glycosylation PhosphoSitePlus
T1551 O-Glycosylation GlyGen 30459171
T1565 O-Glycosylation GlyGen 23584533
S1656 O-Glycosylation PhosphoSitePlus
S1657 O-Glycosylation PhosphoSitePlus
S1658 O-Glycosylation PhosphoSitePlus
T1661 O-Glycosylation PhosphoSitePlus
T1732 O-Glycosylation PhosphoSitePlus
T1834 Phosphorylation PhosphoSitePlus
T1853 Phosphorylation PhosphoSitePlus
T1877 Phosphorylation PhosphoSitePlus
S1924 Phosphorylation PhosphoSitePlus
K1928 Ubiquitination PhosphoSitePlus
T1931 Phosphorylation PhosphoSitePlus
T1933 Phosphorylation PhosphoSitePlus
T1946 Phosphorylation PhosphoSitePlus
T1951 Phosphorylation PhosphoSitePlus
Y1970 Phosphorylation PhosphoSitePlus
K1971 Acetylation PhosphoSitePlus
Y1975 Phosphorylation PhosphoSitePlus
N1999 O-Glycosylation GlyGen 23584533
T2061 O-Glycosylation GlyGen 23584533
S2073 Phosphorylation PhosphoSitePlus
T2090 O-Glycosylation PhosphoSitePlus
T2111 O-Glycosylation IEDB 27550523
T2151 O-Glycosylation PhosphoSitePlus
T2152 O-Glycosylation PhosphoSitePlus
T2155 O-Glycosylation PhosphoSitePlus
T2156 O-Glycosylation PhosphoSitePlus
T2158 O-Glycosylation PhosphoSitePlus
N2199 N-Glycosylation GlyGen   UniProt 16037490
T2202 O-Glycosylation GlyGen 30459171
T2211 O-Glycosylation GlyGen 30459171
N2345 O-Glycosylation GlyGen 23584533
Y2349 Phosphorylation PhosphoSitePlus
Y2403 Phosphorylation PhosphoSitePlus
S2432 O-Glycosylation PhosphoSitePlus
S2432 Phosphorylation PhosphoSitePlus
T2436 O-Glycosylation PhosphoSitePlus
T2437 O-Glycosylation PhosphoSitePlus
S2440 O-Glycosylation PhosphoSitePlus
S2440 Phosphorylation PhosphoSitePlus
Y2441 Phosphorylation PhosphoSitePlus
Y2444 Phosphorylation PhosphoSitePlus
S2445 Phosphorylation PhosphoSitePlus
T2454 Phosphorylation PhosphoSitePlus   UniProt 24275569
S2475 Phosphorylation PhosphoSitePlus   UniProt 26091039, 17081983, 24275569, ...18318008
Site PTM Type PTM Enzyme Score Source PMID
T1271 Phosphorylation PhosphoSitePlus
S2384 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S904 Phosphorylation HPRD 18691976
S909 Phosphorylation HPRD 17322306
S2131 Phosphorylation HPRD 19824718
S2139 Phosphorylation HPRD 19824718
S2174 Phosphorylation HPRD 20166139, 17081983, 18452278
Site PTM Type PTM Enzyme Score Source PMID
N430 N-Glycosylation PRO 29741879
N528 N-Glycosylation PRO 26791533, 29671580, 29741879
N542 N-Glycosylation PRO 24279413, 26791533, 29671580
S904 Phosphorylation HPRD 18691976
S909 Phosphorylation HPRD 17322306
N1007 N-Glycosylation PRO 24279413, 26791533, 29671580
S2432 Phosphorylation HPRD 19824718
S2440 Phosphorylation HPRD 19824718
S2475 Phosphorylation HPRD 20166139, 17081983, 18452278
Site PTM Type PTM Enzyme Score Source PMID
S904 Phosphorylation HPRD 18691976
S909 Phosphorylation HPRD 17322306
S2285 Phosphorylation HPRD 19824718
S2293 Phosphorylation HPRD 19824718
S2328 Phosphorylation HPRD 20166139, 17081983, 18452278
Site PTM Type PTM Enzyme Score Source PMID
S904 Phosphorylation HPRD 18691976
S909 Phosphorylation HPRD 17322306
S2310 Phosphorylation HPRD 19824718
S2318 Phosphorylation HPRD 19824718
S2353 Phosphorylation HPRD 20166139, 17081983, 18452278
Site PTM Type PTM Enzyme Score Source PMID
S2073 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S904 Phosphorylation HPRD 18691976
S909 Phosphorylation HPRD 17322306
S2251 Phosphorylation HPRD 19824718
S2259 Phosphorylation HPRD 19824718
S2294 Phosphorylation HPRD 20166139, 17081983, 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S41 F41 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S41 A41 Biomuta DOID:1324 / lung cancer [ cosmic ]
T136 I136 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S283 Y283 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T287 P287 Biomuta DOID:1324 / lung cancer [ cosmic ]
N430 D430 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K486 T486 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T715 M715 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S909 F909 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S968 P968 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1122 R1122 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T1367 S1367 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1657 I1657 Biomuta DOID:363 / uterine cancer [ icgc ]
T1931 M1931 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T1946 I1946 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
Y1970 C1970 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K1971 N1971 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
T2090 N2090 Biomuta DOID:263 / kidney cancer [ cosmic ]
S2131 T2131 Biomuta DOID:1324 / lung cancer [ cosmic ]
T2156 M2156 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T2158 A2158 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S2174 Y2174 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S2174 P2174 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2251 T2251 Biomuta DOID:1324 / lung cancer [ cosmic ]
S2285 T2285 Biomuta DOID:1324 / lung cancer [ cosmic ]
S2294 P2294 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2294 Y2294 Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:4159 / skin cancer [ cosmic, icgc ]
S2310 T2310 Biomuta DOID:1324 / lung cancer [ cosmic ]
S2328 P2328 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2328 Y2328 Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:4159 / skin cancer [ cosmic, icgc ]
S2353 P2353 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2353 Y2353 Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:4159 / skin cancer [ cosmic, icgc ]
S2384 P2384 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2384 Y2384 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S2432 T2432 Biomuta DOID:1324 / lung cancer [ cosmic ]
S2445 Y2445 Biomuta DOID:3571 / liver cancer [ cosmic ]
S2475 P2475 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2475 Y2475 Biomuta DOID:9256 / colorectal cancer [ icgc ]