iPTMnet Report for P02686 (MBP)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P02686 / MBP_HUMAN
Protein Name Myelin basic protein
Gene Name Name: MBP
Organism Homo sapiens (Human)

PRO ID PR:P02686
DAG View
PRO Name myelin basic protein (human)
Definition A myelin basic protein that is encoded in the genome of human.
Short Label hMBP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P02686 (MBP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
G2 Acetylation UniProt 7544282
S16 Phosphorylation PhosphoSitePlus
S19 Phosphorylation PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
T38 Phosphorylation PhosphoSitePlus
T39 Phosphorylation PhosphoSitePlus
S40 Phosphorylation PhosphoSitePlus
T65 Phosphorylation neXtProt 14517248
S87 Phosphorylation PhosphoSitePlus
S96 Phosphorylation P27361 (MAPK3) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 1699809
T106 Phosphorylation PhosphoSitePlus
S114 Phosphorylation PhosphoSitePlus
S141 Phosphorylation PhosphoSitePlus
S146 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus 2413024
Y148 Phosphorylation PhosphoSitePlus
S153 Phosphorylation PhosphoSitePlus
T154 Phosphorylation PhosphoSitePlus
T169 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus 2413024
S190 Phosphorylation P17612 (PRKACA) neXtProt 2413024
Y203 Phosphorylation PhosphoSitePlus
S205 Phosphorylation PhosphoSitePlus
T229 Phosphorylation P28482 (MAPK1) Signor 12760422
T232 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) phospho.ELM   PhosphoSitePlus   Signor 1939237, 16401070
R241 Methylation PhosphoSitePlus   UniProt 5128665
S249 O-Glycosylation GlyGen 29485866, 28657654
S249 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus 2413024
Y261 Phosphorylation PhosphoSitePlus
S266 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus 2413024
T283 Phosphorylation PhosphoSitePlus
S285 Phosphorylation PhosphoSitePlus
S295 Phosphorylation P17612 (PRKACA) neXtProt 2413024
S299 Phosphorylation Q8TAS1 (UHMK1) phospho.ELM   Signor   UniProt 10880969, 16401070
Site PTM Type PTM Enzyme Score Source PMID
S96 Phosphorylation HPRD 17081983
S114 Phosphorylation HPRD 20058876
S141 Phosphorylation P17252 (PRKCA) , P17612 (PRKACA) HPRD 2413024
S146 Phosphorylation P17612 (PRKACA) , P17252 (PRKCA) HPRD 2413024
T169 Phosphorylation P17612 (PRKACA) HPRD 2413024
S190 Phosphorylation P17252 (PRKCA) , P17612 (PRKACA) HPRD 2413024
S205 Phosphorylation HPRD 2449425
T229 Phosphorylation P28482 (MAPK1) HPRD 2449425, 12760422
T232 Phosphorylation P28482 (MAPK1) HPRD 12760422
S249 Phosphorylation P17252 (PRKCA) HPRD 2413024
S266 Phosphorylation P17612 (PRKACA) , P17252 (PRKCA) HPRD 2413024
S285 Phosphorylation P17252 (PRKCA) HPRD 2413024
S295 Phosphorylation P17252 (PRKCA) , P17612 (PRKACA) HPRD 2413024
Site PTM Type PTM Enzyme Score Source PMID
S96 Phosphorylation HPRD 17081983
S114 Phosphorylation HPRD 20058876
S141 Phosphorylation P17612 (PRKACA) , P17252 (PRKCA) HPRD 2413024
S146 Phosphorylation P17252 (PRKCA) , P17612 (PRKACA) HPRD 2413024
T169 Phosphorylation P17612 (PRKACA) HPRD 2413024
S190 Phosphorylation P17252 (PRKCA) , P17612 (PRKACA) HPRD   PhosphoSitePlus 2413024
Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation P17612 (PRKACA) , P17252 (PRKCA) HPRD 2413024
S13 Phosphorylation P17612 (PRKACA) , P17252 (PRKCA) HPRD 2413024
T36 Phosphorylation P17612 (PRKACA) HPRD 2413024
S57 Phosphorylation P17252 (PRKCA) , P17612 (PRKACA) HPRD   PhosphoSitePlus 2413024
S68 Phosphorylation PhosphoSitePlus
S98 Phosphorylation HPRD 2449425
T122 Phosphorylation HPRD 2449425
S142 Phosphorylation P17252 (PRKCA) HPRD 2413024
S159 Phosphorylation P17612 (PRKACA) , P17252 (PRKCA) HPRD 2413024
S178 Phosphorylation P17252 (PRKCA) HPRD 2413024
S188 Phosphorylation P17252 (PRKCA) , P17612 (PRKACA) HPRD 2413024
Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation P17252 (PRKCA) , P17612 (PRKACA) HPRD 2413024
S13 Phosphorylation P17252 (PRKCA) , P17612 (PRKACA) HPRD 2413024
T36 Phosphorylation P17612 (PRKACA) HPRD 2413024
S57 Phosphorylation P17612 (PRKACA) , P17252 (PRKCA) HPRD   PhosphoSitePlus 2413024
S68 Phosphorylation PhosphoSitePlus
S98 Phosphorylation HPRD 2449425
T122 Phosphorylation HPRD 2449425
S148 Phosphorylation P17252 (PRKCA) , P17612 (PRKACA) HPRD 2413024
S167 Phosphorylation P17252 (PRKCA) HPRD 2413024
S177 Phosphorylation P17612 (PRKACA) , P17252 (PRKCA) HPRD 2413024
Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation P17252 (PRKCA) , P17612 (PRKACA) HPRD 2413024
S13 Phosphorylation P17612 (PRKACA) , P17252 (PRKCA) HPRD 2413024
T36 Phosphorylation P17612 (PRKACA) HPRD 2413024
S57 Phosphorylation P17612 (PRKACA) , P17252 (PRKCA) HPRD 2413024
S72 Phosphorylation HPRD 2449425
T96 Phosphorylation HPRD 2449425
T99 Phosphorylation P28482 (MAPK1) HPRD 15380617
S116 Phosphorylation P17252 (PRKCA) HPRD 2413024
S133 Phosphorylation P17252 (PRKCA) , P17612 (PRKACA) HPRD 2413024
S152 Phosphorylation P17252 (PRKCA) HPRD 2413024
S162 Phosphorylation P17252 (PRKCA) , Q15139 (PRKD1) , P17612 (PRKACA) HPRD   neXtProt   PhosphoSitePlus 17939756, 2413024
Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation P17252 (PRKCA) , P17612 (PRKACA) HPRD 2413024
S13 Phosphorylation P17252 (PRKCA) , P17612 (PRKACA) HPRD 2413024
T36 Phosphorylation P17612 (PRKACA) HPRD 2413024
S57 Phosphorylation P17252 (PRKCA) , P17612 (PRKACA) HPRD 2413024
S72 Phosphorylation HPRD 2449425
T96 Phosphorylation HPRD 2449425
S122 Phosphorylation P17612 (PRKACA) , P17252 (PRKCA) HPRD 2413024
S141 Phosphorylation P17252 (PRKCA) HPRD 2413024
S151 Phosphorylation P17612 (PRKACA) , P17252 (PRKCA) HPRD 2413024


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
G2 R2 Biomuta DOID:4159 / skin cancer [ cosmic ]
S96 F96 Biomuta DOID:4159 / skin cancer [ cosmic, cosmic ]
T96 A96 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
T96 M96 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T122 A122 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
T122 M122 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S141 A141 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S151 G151 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1793 / pancreatic cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S152 A152 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S162 G162 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S167 A167 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S177 G177 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S178 A178 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S188 G188 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1793 / pancreatic cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
T229 M229 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T229 A229 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
R241 I241 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S285 A285 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S295 G295 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]