iPTMnet Report for P02545 (LMNA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P02545 / LMNA_HUMAN
Protein Name Prelamin-A/C precursor
Gene Name Name: LMNA
Synonyms:LMN1;
Organism Homo sapiens (Human)

PRO ID PR:P02545
DAG View
PRO Name prelamin-A/C (human)
Definition A prelamin-A/C that is encoded in the genome of human.
Short Label hLMNA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P02545 (LMNA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 20068231
T3 Phosphorylation PhosphoSitePlus   UniProt 20068231
S5 Phosphorylation phospho.ELM   PhosphoSitePlus 8477740
T10 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S12 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...24275569
S17 Phosphorylation PhosphoSitePlus
S18 O-Glycosylation GlyGen 30444036, 30620550, 31492838, ...33465208, 32870666, 35289036, 29351928, 22661428, 29237092, 29772801, 34725712, 31373491, 32119511, 30059200, 23271734, 32574038, 35132862, 28604694, 22121020, 28657654, 27655845, 34846842, 33214551, 30379171, 26853435, 34065225, 25367160, 35254053, 34019948, 35083852, 22967762, 36240223, 28510447, 20068230
S18 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T19 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 16964243, 23870088, ...18669648, 7915280, 24275569, 20068231, 17081983
S22 Phosphorylation P28482 (MAPK1) , P06493 (CDK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18234856, 16964243, 29342872, ...20147387, 33145443, 23186163, 1555589, 33520998, 24275569, 19165338, 27556400, 33767161, 18220336, 23870088, 33605210, 7915280, 18815303, 22367880, 30190500, 22028470, 17287340, 17081983, 18669648, 20068231
T24 O-Glycosylation GlyGen 33465208
T24 Phosphorylation PhosphoSitePlus
T27 O-Glycosylation GlyGen 30444036, 30620550, 31492838, ...33465208, 32870666, 35289036, 29351928, 22661428, 29237092, 29772801, 34725712, 31373491, 32119511, 30059200, 23271734, 32574038, 35132862, 28604694, 22121020, 28657654, 27655845, 34846842, 33214551, 30379171, 26853435, 34065225, 25367160, 35254053, 34019948, 35083852, 22967762, 36240223, 28510447, 20068230
T27 Phosphorylation PhosphoSitePlus
K32 Ubiquitination PhosphoSitePlus
R41 Methylation PhosphoSitePlus
Y45 Phosphorylation PhosphoSitePlus   RLIMS-P 34385357
R48 Methylation PhosphoSitePlus
S51 Phosphorylation PhosphoSitePlus   UniProt 23186163
T64 Phosphorylation PhosphoSitePlus
S66 Phosphorylation PhosphoSitePlus   UniProt 23186163
S71 Phosphorylation PhosphoSitePlus   UniProt 23186163
S75 Phosphorylation PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
Y81 Phosphorylation PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
T91 O-Glycosylation GlyGen 30444036, 30620550, 31492838, ...33465208, 32870666, 35289036, 29351928, 22661428, 29237092, 29772801, 34725712, 31373491, 32119511, 30059200, 23271734, 32574038, 35132862, 28604694, 22121020, 28657654, 27655845, 34846842, 33214551, 30379171, 26853435, 34065225, 25367160, 35254053, 34019948, 35083852, 22967762, 36240223, 28510447, 20068230
S94 Phosphorylation PhosphoSitePlus
K97 Acetylation PhosphoSitePlus
K97 Sumoylation PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
S107 Phosphorylation PhosphoSitePlus   UniProt 23186163
K108 Acetylation PhosphoSitePlus   UniProt 19608861
K108 Ubiquitination PhosphoSitePlus
K114 Acetylation PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
K123 Ubiquitination PhosphoSitePlus
K135 Acetylation PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus
K144 Acetylation PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
S149 Phosphorylation PhosphoSitePlus
T150 Phosphorylation PhosphoSitePlus
S153 Phosphorylation PhosphoSitePlus
K155 Acetylation PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
T157 Phosphorylation PhosphoSitePlus
R166 Methylation PhosphoSitePlus
K171 Acetylation PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
K180 Acetylation PhosphoSitePlus
K180 Ubiquitination PhosphoSitePlus
K181 Ubiquitination PhosphoSitePlus
R189 Methylation PhosphoSitePlus
T199 Phosphorylation phospho.ELM 8477740
K201 Acetylation PhosphoSitePlus
K201 Sumoylation PhosphoSitePlus
K201 Ubiquitination PhosphoSitePlus
K208 Acetylation PhosphoSitePlus
K208 Sumoylation PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
Y211 Phosphorylation PhosphoSitePlus
S212 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231, 24275569
T218 Phosphorylation PhosphoSitePlus
K219 Sumoylation PhosphoSitePlus
K219 Ubiquitination PhosphoSitePlus
T224 Phosphorylation IEDB   PhosphoSitePlus 35494241
K233 Acetylation PhosphoSitePlus
K233 Sumoylation PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
Y259 Phosphorylation PhosphoSitePlus
K260 Acetylation PhosphoSitePlus
K260 Sumoylation PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
K261 Acetylation PhosphoSitePlus
K261 Ubiquitination PhosphoSitePlus
K265 Acetylation PhosphoSitePlus
K265 Sumoylation PhosphoSitePlus
K265 Ubiquitination PhosphoSitePlus
S268 O-Glycosylation GlyGen 30444036, 30620550, 31492838, ...33465208, 32870666, 35289036, 29351928, 22661428, 29237092, 29772801, 34725712, 31373491, 32119511, 30059200, 23271734, 32574038, 35132862, 28604694, 22121020, 28657654, 27655845, 34846842, 33214551, 30379171, 26853435, 34065225, 25367160, 35254053, 34019948, 35083852, 22967762, 36240223, 28510447, 20068230
K270 Acetylation PhosphoSitePlus   UniProt 19608861
K270 Sumoylation PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
S277 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 20068231
S282 Phosphorylation PhosphoSitePlus
S295 Phosphorylation PhosphoSitePlus
S301 Phosphorylation P31749 (AKT1) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 18808171, 23186163, 23430973, ...18669648, 24275569, 20068231
S303 Phosphorylation PhosphoSitePlus
S307 Phosphorylation O14757 (CHEK1) PhosphoSitePlus   UniProt 21851590, 24275569
K311 Acetylation PhosphoSitePlus   UniProt 19608861
K311 Sumoylation PhosphoSitePlus
K311 Ubiquitination PhosphoSitePlus
K316 Ubiquitination PhosphoSitePlus
K319 Acetylation PhosphoSitePlus
K319 Ubiquitination PhosphoSitePlus
S326 Phosphorylation PhosphoSitePlus
Y359 Phosphorylation PhosphoSitePlus
Y376 Phosphorylation PhosphoSitePlus
K378 Acetylation PhosphoSitePlus
K378 Sumoylation PhosphoSitePlus
K378 Ubiquitination PhosphoSitePlus
R386 Methylation PhosphoSitePlus
S390 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   Signor   UniProt 21406692, 16083285, 23186163, ...16964243, 18220336, 15302935, 18669648, 24275569, 18815303, 19165338, 20068231, 17081983
S392 Phosphorylation P06493 (CDK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 33145443, 21406692, 16083285, ...23186163, 16964243, 18220336, 23870088, 18234856, 15302935, 30190500, 18669648, 7915280, 18815303, 19165338, 20147387, 22367880, 20068231, 17081983
T394 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S395 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 16964243, 18669648, 24275569, ...20068231, 17081983
S398 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S403 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 16083285, 7915280, 24275569
S404 Phosphorylation P31749 (AKT1) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23430973, 18808171, ...7915280, 24275569, 20068231
S406 Phosphorylation phospho.ELM   PhosphoSitePlus 16083285
S407 Phosphorylation phospho.ELM   PhosphoSitePlus 16083285, 17081983
T409 Phosphorylation phospho.ELM   PhosphoSitePlus 16083285
S414 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 20068231, ...24275569, 27869121
T416 Phosphorylation phospho.ELM   PhosphoSitePlus 8477740
K417 Acetylation PhosphoSitePlus
K417 Sumoylation PhosphoSitePlus
K417 Ubiquitination PhosphoSitePlus
K418 Acetylation PhosphoSitePlus
K418 Ubiquitination PhosphoSitePlus
K420 Acetylation PhosphoSitePlus
K420 Sumoylation PhosphoSitePlus
K420 Ubiquitination PhosphoSitePlus
S423 O-Glycosylation GlyGen 30444036, 30620550, 31492838, ...33465208, 32870666, 35289036, 29351928, 22661428, 29237092, 29772801, 34725712, 31373491, 32119511, 30059200, 23271734, 32574038, 35132862, 28604694, 22121020, 28657654, 27655845, 34846842, 33214551, 30379171, 26853435, 34065225, 25367160, 35254053, 34019948, 35083852, 22967762, 36240223, 28510447, 20068230
S423 Phosphorylation phospho.ELM   PhosphoSitePlus 16083285
T424 O-Glycosylation GlyGen 33465208
T424 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S426 Phosphorylation PhosphoSitePlus
S429 Phosphorylation PhosphoSitePlus   UniProt 23186163
S431 Phosphorylation PhosphoSitePlus   UniProt 20068231
T436 O-Glycosylation GlyGen 25367160
S437 O-Glycosylation GlyGen 25367160
S437 Phosphorylation PhosphoSitePlus
K450 Acetylation PhosphoSitePlus   UniProt 19608861
K450 Sumoylation PhosphoSitePlus
K450 Ubiquitination PhosphoSitePlus
K457 Acetylation PhosphoSitePlus
K457 Ubiquitination PhosphoSitePlus
S458 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...24275569, 20068231
S463 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231, 24275569
K470 Acetylation PhosphoSitePlus
K470 Methylation PhosphoSitePlus
K470 Ubiquitination PhosphoSitePlus
T480 Phosphorylation phospho.ELM 8477740
Y481 Phosphorylation PhosphoSitePlus
K486 Sumoylation PhosphoSitePlus
K486 Ubiquitination PhosphoSitePlus
T488 Phosphorylation PhosphoSitePlus
T505 Phosphorylation PhosphoSitePlus   UniProt 20068231
S507 Phosphorylation PhosphoSitePlus
T510 Phosphorylation PhosphoSitePlus
K515 Acetylation PhosphoSitePlus
C522 S-Nitrosylation dbSNO 22178444
S525 Phosphorylation phospho.ELM   PhosphoSitePlus 8477740
T528 Phosphorylation PhosphoSitePlus
S533 Phosphorylation PhosphoSitePlus   UniProt 23186163
T534 Phosphorylation PhosphoSitePlus
S546 Phosphorylation PhosphoSitePlus
T548 Phosphorylation PhosphoSitePlus
S568 Phosphorylation PhosphoSitePlus
S583 Phosphorylation PhosphoSitePlus
T585 O-Glycosylation GlyGen 30444036, 30620550, 31492838, ...33465208, 32870666, 35289036, 29351928, 22661428, 29237092, 29772801, 34725712, 31373491, 32119511, 30059200, 23271734, 32574038, 35132862, 28604694, 22121020, 28657654, 27655845, 34846842, 33214551, 30379171, 26853435, 34065225, 25367160, 35254053, 34019948, 35083852, 22967762, 36240223, 28510447, 20068230
T585 Phosphorylation PhosphoSitePlus
T590 O-Glycosylation GlyGen 33465208
T590 Phosphorylation PhosphoSitePlus
K597 Acetylation PhosphoSitePlus
K597 Sumoylation PhosphoSitePlus
K597 Ubiquitination PhosphoSitePlus
S599 O-Glycosylation GlyGen 30444036, 30620550, 31492838, ...33465208, 32870666, 35289036, 29351928, 22661428, 29237092, 29772801, 34725712, 31373491, 32119511, 30059200, 23271734, 32574038, 32938750, 35132862, 28604694, 22121020, 28657654, 27655845, 34846842, 33214551, 30379171, 26853435, 34065225, 25367160, 35254053, 34019948, 35083852, 22967762, 36240223, 28510447, 20068230
S599 Phosphorylation PhosphoSitePlus
S601 O-Glycosylation GlyGen 30444036, 30620550, 31492838, ...33465208, 32870666, 35289036, 29351928, 22661428, 29237092, 29772801, 34725712, 31373491, 32119511, 30059200, 23271734, 32574038, 35132862, 28604694, 22121020, 28657654, 27655845, 34846842, 33214551, 30379171, 26853435, 34065225, 25367160, 35254053, 34019948, 35083852, 22967762, 36240223, 28510447, 20068230
S601 Phosphorylation PhosphoSitePlus
S603 O-Glycosylation GlyGen 30444036, 30620550, 31492838, ...33465208, 32870666, 35289036, 29351928, 22661428, 29237092, 29772801, 34725712, 31373491, 32119511, 30059200, 23271734, 32574038, 35132862, 28604694, 22121020, 28657654, 27655845, 34846842, 33214551, 30379171, 26853435, 34065225, 25367160, 35254053, 34019948, 35083852, 22967762, 36240223, 28510447, 20068230
S603 Phosphorylation PhosphoSitePlus
S612 O-Glycosylation GlyGen   PhosphoSitePlus 30444036, 30620550, 31492838, ...33465208, 32870666, 35289036, 29351928, 22661428, 29237092, 29772801, 34725712, 31373491, 32119511, 30059200, 23271734, 32574038, 32938750, 35132862, 28604694, 22121020, 28657654, 27655845, 34846842, 33214551, 30379171, 26853435, 34065225, 25367160, 35254053, 34019948, 35083852, 22967762, 36240223, 28510447, 20068230
S612 Phosphorylation PhosphoSitePlus   UniProt 24275569
S613 O-Glycosylation GlyGen 30444036, 30620550, 31492838, ...33465208, 32870666, 35289036, 29351928, 22661428, 29237092, 29772801, 34725712, 31373491, 32119511, 30059200, 23271734, 32574038, 32938750, 35132862, 28604694, 22121020, 28657654, 27655845, 34846842, 33214551, 30379171, 26853435, 34065225, 25367160, 35254053, 34019948, 35083852, 22967762, 36240223, 28510447, 20068230
S613 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S615 O-Glycosylation GlyGen 30444036, 30620550, 31492838, ...33465208, 32870666, 35289036, 29351928, 22661428, 29237092, 29772801, 34725712, 31373491, 32119511, 30059200, 23271734, 32574038, 35132862, 28604694, 22121020, 28657654, 27655845, 34846842, 33214551, 30379171, 26853435, 34065225, 25367160, 35254053, 34019948, 35083852, 22967762, 36240223, 28510447, 20068230
S615 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S616 O-Glycosylation GlyGen 30444036, 30620550, 31492838, ...33465208, 32870666, 35289036, 29351928, 22661428, 29237092, 29772801, 34725712, 31373491, 32119511, 30059200, 23271734, 32574038, 35132862, 28604694, 22121020, 28657654, 27655845, 34846842, 33214551, 30379171, 26853435, 34065225, 25367160, 35254053, 34019948, 35083852, 22967762, 36240223, 28510447, 20068230
S616 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S618 O-Glycosylation GlyGen 30444036, 30620550, 31492838, ...33465208, 32870666, 35289036, 29351928, 22661428, 29237092, 29772801, 34725712, 31373491, 32119511, 30059200, 23271734, 32574038, 35132862, 28604694, 22121020, 28657654, 27655845, 34846842, 33214551, 30379171, 26853435, 34065225, 25367160, 35254053, 34019948, 35083852, 22967762, 36240223, 28510447, 20068230
S618 Phosphorylation PhosphoSitePlus
S619 O-Glycosylation GlyGen 30444036, 30620550, 31492838, ...33465208, 32870666, 35289036, 29351928, 22661428, 29237092, 29772801, 34725712, 31373491, 32119511, 30059200, 23271734, 32574038, 35132862, 28604694, 22121020, 28657654, 27655845, 34846842, 33214551, 30379171, 26853435, 34065225, 25367160, 35254053, 34019948, 35083852, 22967762, 36240223, 28510447, 20068230
S619 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T621 O-Glycosylation GlyGen 30444036, 30620550, 31492838, ...33465208, 32870666, 35289036, 29351928, 22661428, 29237092, 29772801, 34725712, 31373491, 32119511, 30059200, 23271734, 32574038, 35132862, 28604694, 22121020, 28657654, 27655845, 34846842, 33214551, 30379171, 26853435, 34065225, 25367160, 35254053, 34019948, 35083852, 22967762, 36240223, 28510447, 20068230
T621 Phosphorylation PhosphoSitePlus
T623 O-Glycosylation GlyGen 30444036, 30620550, 31492838, ...33465208, 32870666, 35289036, 29351928, 22661428, 29237092, 29772801, 34725712, 31373491, 32119511, 30059200, 23271734, 32574038, 35132862, 28604694, 22121020, 28657654, 27655845, 34846842, 33214551, 30379171, 26853435, 34065225, 25367160, 35254053, 34019948, 35083852, 22967762, 36240223, 28510447, 20068230
T623 Phosphorylation PhosphoSitePlus
S625 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 30402260, 8477740
S628 O-Glycosylation GlyGen 30444036, 30620550, 31492838, ...33465208, 32870666, 35289036, 29351928, 22661428, 29237092, 29772801, 34725712, 31373491, 32119511, 30059200, 23271734, 32574038, 35132862, 28604694, 22121020, 28657654, 27655845, 34846842, 33214551, 30379171, 26853435, 34065225, 25367160, 35254053, 34019948, 35083852, 22967762, 36240223, 28510447, 20068230
S628 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18220336, ...18669648, 17924679, 20068231, 16964243
S632 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 16964243, ...18220336, 18669648, 20068231
S636 O-Glycosylation GlyGen 30444036, 30620550, 31492838, ...33465208, 32870666, 35289036, 29351928, 22661428, 29237092, 29772801, 34725712, 31373491, 32119511, 30059200, 23271734, 32574038, 35132862, 28604694, 22121020, 28657654, 27655845, 34846842, 33214551, 30379171, 26853435, 34065225, 25367160, 35254053, 34019948, 35083852, 22967762, 36240223, 28510447, 20068230
S636 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 16964243, ...33520998, 18669648, 24275569, 20068231, 17081983
T643 O-Glycosylation GlyGen   PhosphoSitePlus 30444036, 30620550, 31492838, ...33465208, 32870666, 35289036, 29351928, 22661428, 29237092, 29772801, 34725712, 31373491, 32119511, 30059200, 23271734, 32574038, 32938750, 35132862, 28604694, 22121020, 28657654, 27655845, 34846842, 33214551, 30379171, 26853435, 34065225, 25367160, 35254053, 34019948, 35083852, 22967762, 36240223, 28510447, 20068230
T643 Phosphorylation PhosphoSitePlus
R644 Methylation PhosphoSitePlus
S651 Phosphorylation PhosphoSitePlus
S652 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
T655 Phosphorylation PhosphoSitePlus
S657 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T3 Phosphorylation HPRD 20068231
T10 Phosphorylation HPRD 17081983
S12 Phosphorylation HPRD 18212344, 19691289, 19651622, ...18669648, 20068231, 16964243
S17 Phosphorylation HPRD 18691976, 19691289
S18 Phosphorylation HPRD 18691976, 18669648, 19415658, ...20068231, 19691289
T19 Phosphorylation P17252 (PRKCA) , P06493 (CDK1) HPRD 19413330, 7925482, 18212344, ...18767875, 19691289, 19664995, 19651622, 18669648, 16565220, 17924679, 19415658, 20068231, 16964243
S22 Phosphorylation P06493 (CDK1) HPRD 16964243, 18707149, 18452278, ...18691976, 2344612, 7925482, 18212344, 19691289, 16565220, 19413330, 18767875, 20058876, 19007248, 19651622, 18491316, 17287340, 19664994, 19664995, 18669648, 20166139, 19415658, 20068231, 17924679
T24 Phosphorylation HPRD 19651622, 17081983, 20068231
S51 Phosphorylation HPRD 19691289
T64 Phosphorylation HPRD 20068231
S66 Phosphorylation HPRD 19691289, 20068231
S71 Phosphorylation HPRD 19691289
S94 Phosphorylation HPRD 17081983
S107 Phosphorylation HPRD 20068231
S212 Phosphorylation HPRD 20068231
S277 Phosphorylation HPRD 17081983, 20068231
S282 Phosphorylation HPRD 17081983, 20068231
S301 Phosphorylation HPRD 18669648, 20068231
S390 Phosphorylation HPRD 19664995, 18691976, 18491316, ...18212344, 18767875, 18077418, 15302935, 19691289, 18452278, 19007248, 19651622, 19664994, 18669648, 16565220, 20166139, 20068230, 17924679, 19415658, 20068231, 16964243
S392 Phosphorylation P06493 (CDK1) HPRD 19664995, 18691976, 18491316, ...7925482, 18212344, 16964243, 18767875, 18077418, 19664994, 19691289, 19007248, 19651622, 18669648, 20166139, 2344612, 19415658, 20068231, 17924679
T394 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 19415658
S395 Phosphorylation HPRD 17322306, 16964243, 18767875, ...18077418, 19007248, 19651622, 18669648, 20166139, 19415658, 20068231, 17924679
S398 Phosphorylation HPRD 18669648, 20068231
S403 Phosphorylation P17252 (PRKCA) HPRD 18691976, 7925482, 19562805, ...19651622, 20166139, 20068231, 17924679
S404 Phosphorylation P17252 (PRKCA) HPRD 18691976, 7925482, 19664995, ...19651622, 18707149, 20166139, 20068231, 17924679
S406 Phosphorylation HPRD 19651622, 20166139, 16083285, ...20068231, 18707149
S407 Phosphorylation HPRD 19651622, 20166139, 16083285, ...20068231, 18707149
T409 Phosphorylation HPRD 19651622, 16083285, 20068231
S414 Phosphorylation HPRD 19651622, 17081983, 20068231, ...17924679
T416 Phosphorylation HPRD 19651622, 17081983, 20068231, ...17924679
S423 Phosphorylation HPRD 20166139, 16083285, 20068231
T424 Phosphorylation HPRD 17081983
S426 Phosphorylation HPRD 17081983, 20068231
S428 Phosphorylation HPRD 20068231
S429 Phosphorylation HPRD 20068231
S431 Phosphorylation HPRD 20068231
S458 Phosphorylation HPRD 19651622, 18669648, 18452278, ...20068231, 18707149
S463 Phosphorylation HPRD 20068231
T505 Phosphorylation HPRD 20068231
S525 Phosphorylation P17252 (PRKCA) HPRD 7925482, 8477740
S533 Phosphorylation HPRD 19691289
T534 Phosphorylation HPRD 19691289
S612 Phosphorylation HPRD 17081983
S613 Phosphorylation HPRD 18669648, 17081983, 20068231
S615 Phosphorylation HPRD 18669648, 20068231
S616 Phosphorylation HPRD 18669648, 17081983, 20068231, ...19691289
S618 Phosphorylation HPRD 17081983
S619 Phosphorylation HPRD 18669648, 17081983, 20068231
S625 Phosphorylation HPRD 20068231
S628 Phosphorylation HPRD 16964243, 17322306, 18212344, ...19691289, 19651622, 18669648, 20068231, 17924679
S632 Phosphorylation HPRD 18691976, 16964243, 20058876, ...19691289, 17322306, 18669648, 19415658, 20068231, 17924679
S636 Phosphorylation HPRD 16964243, 17081983, 20058876, ...19691289, 19651622, 18669648, 20166139, 19415658, 20068231, 18212344
T643 Phosphorylation HPRD 17081983
S652 Phosphorylation HPRD 18691976, 18669648, 15302935, ...18212344, 20068231
Site PTM Type PTM Enzyme Score Source PMID
T3 Phosphorylation HPRD 20068231
T10 Phosphorylation HPRD   PhosphoSitePlus 17081983
S12 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18212344, 19691289, 19651622, ...18669648, 20068231, 16964243
S17 Phosphorylation HPRD 18691976, 19691289
S18 Phosphorylation HPRD   phospho.ELM 18691976, 18669648, 19415658, ...20068231, 19691289
T19 Phosphorylation P17252 (PRKCA) , P06493 (CDK1) HPRD   phospho.ELM   PhosphoSitePlus 19413330, 7925482, 16964243, ...18767875, 19691289, 19664995, 19651622, 18669648, 16565220, 17924679, 19415658, 20068231, 18212344
S22 Phosphorylation P06493 (CDK1) HPRD   phospho.ELM   PhosphoSitePlus 16964243, 18707149, 18452278, ...18691976, 2344612, 7925482, 18212344, 19691289, 16565220, 19413330, 18220336, 18767875, 20058876, 19007248, 19651622, 18491316, 17287340, 19664994, 19664995, 18669648, 20166139, 19415658, 20068231, 17924679
T24 Phosphorylation HPRD 19651622, 17081983, 20068231
S51 Phosphorylation HPRD 19691289
T64 Phosphorylation HPRD 20068231
S66 Phosphorylation HPRD 19691289, 20068231
S71 Phosphorylation HPRD 19691289
Y81 Phosphorylation PhosphoSitePlus
S94 Phosphorylation HPRD 17081983
S107 Phosphorylation HPRD 20068231
K114 Acetylation PhosphoSitePlus
K155 Acetylation PhosphoSitePlus
K180 Acetylation PhosphoSitePlus
S212 Phosphorylation HPRD 20068231
S277 Phosphorylation HPRD 17081983, 20068231
S282 Phosphorylation HPRD 17081983, 20068231
S301 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
S303 Phosphorylation PhosphoSitePlus
S390 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 16964243, 19664994, 16565220, ...18691976, 18212344, 19691289, 18452278, 18220336, 18767875, 19007248, 19651622, 18491316, 18077418, 15302935, 19664995, 18669648, 20166139, 20068230, 19415658, 20068231, 17924679
S392 Phosphorylation P06493 (CDK1) HPRD   phospho.ELM   PhosphoSitePlus 19664995, 18691976, 18491316, ...7925482, 18212344, 18220336, 16964243, 18767875, 18077418, 19664994, 19691289, 19007248, 19651622, 18669648, 20166139, 2344612, 19415658, 20068231, 17924679
T394 Phosphorylation HPRD   phospho.ELM 19651622, 18669648, 17081983, ...20068231, 19415658
S395 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17322306, 16964243, 18767875, ...18077418, 19007248, 19651622, 18669648, 20166139, 19415658, 20068231, 17924679
S398 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
S403 Phosphorylation P17252 (PRKCA) HPRD   PhosphoSitePlus 18691976, 7925482, 19562805, ...19651622, 20166139, 20068231, 17924679
S404 Phosphorylation P17252 (PRKCA) HPRD   PhosphoSitePlus 18691976, 7925482, 19664995, ...19651622, 18707149, 20166139, 20068231, 17924679
S406 Phosphorylation HPRD   PhosphoSitePlus 16083285, 19651622, 18707149, ...20166139, 20068231
S407 Phosphorylation HPRD   PhosphoSitePlus 16083285, 19651622, 18707149, ...20166139, 20068231
T409 Phosphorylation HPRD   PhosphoSitePlus 19651622, 16083285, 20068231
S414 Phosphorylation HPRD   PhosphoSitePlus 19651622, 17081983, 20068231, ...17924679
T416 Phosphorylation HPRD   PhosphoSitePlus 19651622, 17081983, 20068231, ...17924679
K417 Acetylation PhosphoSitePlus
K418 Acetylation PhosphoSitePlus
S423 Phosphorylation HPRD 20166139, 16083285, 20068231
T424 Phosphorylation HPRD 17081983
S426 Phosphorylation HPRD 17081983, 20068231
S428 Phosphorylation HPRD 20068231
S429 Phosphorylation HPRD 20068231
S431 Phosphorylation HPRD 20068231
S458 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18452278, 19651622, 18669648, ...18707149, 20068231
S463 Phosphorylation HPRD 20068231
K470 Acetylation PhosphoSitePlus
T505 Phosphorylation HPRD 20068231
S525 Phosphorylation P17252 (PRKCA) HPRD 7925482, 8477740
S533 Phosphorylation HPRD 19691289
T534 Phosphorylation HPRD 19691289
S546 Phosphorylation PhosphoSitePlus
T548 Phosphorylation PhosphoSitePlus
S568 Phosphorylation HPRD   PhosphoSitePlus 20068231, 18452278
S570 Phosphorylation HPRD   PhosphoSitePlus 18669648, 20068231, 18452278
Site PTM Type PTM Enzyme Score Source PMID
T3 Phosphorylation HPRD 20068231
T10 Phosphorylation HPRD 17081983
S12 Phosphorylation HPRD 18212344, 19691289, 19651622, ...18669648, 20068231, 16964243
S17 Phosphorylation HPRD 18691976, 19691289
S18 Phosphorylation HPRD 18691976, 18669648, 19415658, ...20068231, 19691289
T19 Phosphorylation P17252 (PRKCA) , P06493 (CDK1) HPRD 19413330, 7925482, 18212344, ...18767875, 19691289, 19664995, 19651622, 18669648, 16565220, 17924679, 19415658, 20068231, 16964243
S22 Phosphorylation P06493 (CDK1) HPRD 16964243, 18707149, 18452278, ...18691976, 2344612, 7925482, 18212344, 19691289, 16565220, 19413330, 18767875, 20058876, 19007248, 19651622, 18491316, 17287340, 19664994, 19664995, 18669648, 20166139, 19415658, 20068231, 17924679
T24 Phosphorylation HPRD 19651622, 17081983, 20068231
S51 Phosphorylation HPRD 19691289
T64 Phosphorylation HPRD 20068231
S66 Phosphorylation HPRD 19691289, 20068231
S71 Phosphorylation HPRD 19691289
S94 Phosphorylation HPRD 17081983
S107 Phosphorylation HPRD 20068231
S212 Phosphorylation HPRD 20068231
S277 Phosphorylation HPRD 17081983, 20068231
S282 Phosphorylation HPRD 17081983, 20068231
S301 Phosphorylation HPRD 18669648, 20068231
S390 Phosphorylation HPRD 19664995, 18691976, 18491316, ...18212344, 18767875, 18077418, 15302935, 19691289, 18452278, 19007248, 19651622, 19664994, 18669648, 16565220, 20166139, 20068230, 17924679, 19415658, 20068231, 16964243
S392 Phosphorylation P06493 (CDK1) HPRD 19664995, 18691976, 18491316, ...7925482, 18212344, 16964243, 18767875, 18077418, 19664994, 19691289, 19007248, 19651622, 18669648, 20166139, 2344612, 19415658, 20068231, 17924679
T394 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 19415658
S395 Phosphorylation HPRD 17322306, 16964243, 18767875, ...18077418, 19007248, 19651622, 18669648, 20166139, 19415658, 20068231, 17924679
S398 Phosphorylation HPRD 18669648, 20068231
S403 Phosphorylation P17252 (PRKCA) HPRD 18691976, 7925482, 19562805, ...19651622, 20166139, 20068231, 17924679
S404 Phosphorylation P17252 (PRKCA) HPRD 18691976, 7925482, 19664995, ...19651622, 18707149, 20166139, 20068231, 17924679
S406 Phosphorylation HPRD 19651622, 20166139, 16083285, ...20068231, 18707149
S407 Phosphorylation HPRD 19651622, 20166139, 16083285, ...20068231, 18707149
T409 Phosphorylation HPRD 19651622, 16083285, 20068231
S414 Phosphorylation HPRD 19651622, 17081983, 20068231, ...17924679
T416 Phosphorylation HPRD 19651622, 17081983, 20068231, ...17924679
S423 Phosphorylation HPRD 20166139, 16083285, 20068231
T424 Phosphorylation HPRD 17081983
S426 Phosphorylation HPRD 17081983, 20068231
S428 Phosphorylation HPRD 20068231
S429 Phosphorylation HPRD 20068231
S431 Phosphorylation HPRD 20068231
S458 Phosphorylation HPRD 19651622, 18669648, 18452278, ...20068231, 18707149
S463 Phosphorylation HPRD 20068231
T505 Phosphorylation HPRD 20068231
S525 Phosphorylation P17252 (PRKCA) HPRD 7925482, 8477740
S582 Phosphorylation HPRD 17081983
S583 Phosphorylation HPRD 18669648, 17081983, 20068231
S585 Phosphorylation HPRD 18669648, 20068231
S586 Phosphorylation HPRD 18669648, 17081983, 20068231, ...19691289
S588 Phosphorylation HPRD 17081983
S589 Phosphorylation HPRD 18669648, 17081983, 20068231
S595 Phosphorylation HPRD 20068231
S598 Phosphorylation HPRD 16964243, 17322306, 18212344, ...19691289, 19651622, 18669648, 20068231, 17924679
S602 Phosphorylation HPRD 18691976, 16964243, 20058876, ...19691289, 17322306, 18669648, 19415658, 20068231, 17924679
S606 Phosphorylation HPRD 16964243, 17081983, 20058876, ...19691289, 19651622, 18669648, 20166139, 19415658, 20068231, 18212344
T613 Phosphorylation HPRD 17081983
S622 Phosphorylation HPRD 18691976, 18669648, 15302935, ...18212344, 20068231


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:P02545-1 (hLMNA/iso:A) Interaction PR:P03247-1 (E1B/small-T (ADE02)) PRO 10381623
PR:P02545-2 (hLMNA/iso:C) Interaction PR:P03247-1 (E1B/small-T (ADE02)) PRO 10381623
PR:P02545-2 (hLMNA/iso:C) Interaction PR:O60238 (hBNIP3L) PRO 10381623


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S17 I17 Biomuta DOID:4159 / skin cancer [ cosmic ]
S22 L22 Biomuta DOID:1612 / breast cancer [ icgc ]
T27 I27 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
Y45 C45 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S66 F66 Biomuta DOID:4159 / skin cancer [ cosmic ]
K78 E78 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
K78 N78 Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] DOID:4159 / skin cancer [ cosmic, cosmic, cosmic ] DOID:363 / uterine cancer [ cosmic, icgc, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1612 / breast cancer [ icgc ] DOID:11054 / urinary bladder cancer [ cosmic ]
K155 N155 Biomuta DOID:10283 / prostate cancer [ cosmic ]
R166 Q166 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R189 W189 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K208 T208 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K219 M219 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y376 C376 Biomuta DOID:3565 / meningioma [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
Y376 H376 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S395 L395 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S403 F403 Biomuta DOID:4159 / skin cancer [ cosmic ]
S428 C428 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S431 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S463 F463 Biomuta DOID:363 / uterine cancer [ icgc ]