iPTMnet Report for P02538 (KRT6A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P02538 / K2C6A_HUMAN
Protein Name Keratin, type II cytoskeletal 6A
Gene Name Name: KRT6A
Synonyms:K6A,KRT6D;
Organism Homo sapiens (Human)

PRO ID PR:P02538
DAG View
PRO Name keratin, type II cytoskeletal 6A (human)
Definition A keratin, type II cytoskeletal 6A that is encoded in the genome of human.
Short Label hKRT6A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P02538 (KRT6A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation PhosphoSitePlus
S5 Phosphorylation PhosphoSitePlus
S10 Phosphorylation PhosphoSitePlus
R16 Methylation PhosphoSitePlus
S19 Phosphorylation PhosphoSitePlus   RLIMS-P 29191848
S22 Phosphorylation PhosphoSitePlus   RLIMS-P 29191848
R24 Methylation PhosphoSitePlus
S31 Phosphorylation PhosphoSitePlus
S34 Phosphorylation PhosphoSitePlus
S37 Phosphorylation PhosphoSitePlus   RLIMS-P 29191848
R40 Methylation PhosphoSitePlus
S41 Phosphorylation PhosphoSitePlus
R42 Methylation PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus
S58 Phosphorylation PhosphoSitePlus
R59 Methylation PhosphoSitePlus
S60 Phosphorylation PhosphoSitePlus   RLIMS-P 29191848
Y62 Phosphorylation PhosphoSitePlus
S67 Phosphorylation PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus   RLIMS-P 1756717
S76 Phosphorylation PhosphoSitePlus
S80 Phosphorylation PhosphoSitePlus
Y83 Phosphorylation PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
T169 Phosphorylation PhosphoSitePlus
K173 Acetylation PhosphoSitePlus
K173 Methylation PhosphoSitePlus
K173 Sumoylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
S176 Phosphorylation PhosphoSitePlus
K180 Acetylation PhosphoSitePlus
K180 Ubiquitination PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
K204 Ubiquitination PhosphoSitePlus
Y217 Phosphorylation PhosphoSitePlus
S237 Phosphorylation PhosphoSitePlus
K252 Methylation PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
Y253 Phosphorylation PhosphoSitePlus
K259 Methylation PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
Y278 Phosphorylation PhosphoSitePlus
T290 Phosphorylation PhosphoSitePlus
Y302 Phosphorylation PhosphoSitePlus
S332 Phosphorylation PhosphoSitePlus
Y341 Phosphorylation PhosphoSitePlus
S348 Phosphorylation PhosphoSitePlus
Y356 Phosphorylation PhosphoSitePlus
T358 Phosphorylation PhosphoSitePlus
Y360 Phosphorylation PhosphoSitePlus
T366 Phosphorylation PhosphoSitePlus
S393 Phosphorylation PhosphoSitePlus
K426 Acetylation PhosphoSitePlus
Y448 Phosphorylation PhosphoSitePlus
K467 Acetylation PhosphoSitePlus
R475 Methylation PhosphoSitePlus
S540 Phosphorylation PhosphoSitePlus
S541 Phosphorylation PhosphoSitePlus
S546 Phosphorylation PhosphoSitePlus
K550 Methylation PhosphoSitePlus
Y551 Phosphorylation PhosphoSitePlus
T552 Phosphorylation PhosphoSitePlus
S557 Phosphorylation PhosphoSitePlus
S558 Phosphorylation PhosphoSitePlus
S561 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S5 P5 Biomuta DOID:3571 / liver cancer [ cosmic ]
R16 W16 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S19 N19 Biomuta [ cosmic ]
S22 * Biomuta DOID:4362 / cervical cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S31 C31 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]
S37 A37 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S37 F37 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R59 C59 Biomuta DOID:3571 / liver cancer [ cosmic ]
R59 S59 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S71 F71 Biomuta DOID:4159 / skin cancer [ icgc ]
S80 R80 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S80 I80 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K173 * Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S176 F176 Biomuta DOID:4159 / skin cancer [ cosmic ]
S176 P176 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K204 T204 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y253 H253 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T290 N290 Biomuta DOID:363 / uterine cancer [ icgc ]
S332 R332 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S348 R348 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K426 N426 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R475 M475 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S540 R540 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S540 I540 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S541 F541 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T552 I552 Biomuta DOID:363 / uterine cancer [ cosmic ]
T552 S552 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S557 F557 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S561 N561 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]