iPTMnet Report for P02511 (CRYAB)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P02511 / CRYAB_HUMAN
Protein Name Alpha-crystallin B chain
Gene Name Name: CRYAB
Synonyms:CRYA2,HSPB5;
Organism Homo sapiens (Human)

PRO ID PR:P02511
DAG View
PRO Name alpha-crystallin B chain (human)
Definition An alpha-crystallin B chain that is encoded in the genome of human.
Short Label hCRYAB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P02511 (CRYAB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 8142454, 838078
S19 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23950959, 30014472, 31729431, ...12060738, 32650630, 8175657, 27641668
S21 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 12060738
R22 Methylation PhosphoSitePlus
S43 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 12060738
S45 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23950959, 11158243, 30014472, ...31729431, 12060738, 32650630, 20535031, 8175657, 11549345, 27641668
R50 Methylation PhosphoSitePlus
S53 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 12060738
S59 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 20005263, 23950959, 23559016, ...30014472, 31729431, 12060738, 32650630, 20535031, 8175657, 26620801, 30920888, 24275569, 20166139, 27641668, 11158243
S59 Phosphorylation Q16539 (MAPK14) PhosphoSitePlus 20005263
R74 Methylation PhosphoSitePlus
S76 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 12060738
K82 Ubiquitination PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus
K90 Acetylation PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
K92 Acetylation PhosphoSitePlus   UniProt 22120592, 11369851
K92 Ubiquitination PhosphoSitePlus
T132 Phosphorylation PhosphoSitePlus
T134 Phosphorylation PhosphoSitePlus
S135 Phosphorylation PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
T144 Phosphorylation PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
T158 Phosphorylation PhosphoSitePlus
T162 O-Glycosylation GlyGen 23271734, 8639509, 30379171, ...31492838, 35254053, 33723378, 1730617, 28657654, 29385708
K166 Acetylation PhosphoSitePlus   UniProt 22120592
K166 Ubiquitination PhosphoSitePlus
T170 O-Glycosylation GlyGen   PhosphoSitePlus 23271734, 8639509, 30379171, ...31492838, 35254053, 26620801, 33723378, 1730617, 28657654, 29385708


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S19 Y19 Biomuta DOID:1324 / lung cancer [ cosmic ]
S45 C45 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R50 W50 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
R50 Q50 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S135 L135 Biomuta DOID:1324 / lung cancer [ cosmic ]
T170 A170 Biomuta [ cosmic ]