iPTMnet Report for P02100 (HBE1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P02100 / HBE_HUMAN
Protein Name Hemoglobin subunit epsilon
Gene Name Name: HBE1
Synonyms:HBE;
Organism Homo sapiens (Human)

PRO ID PR:P02100
DAG View
PRO Name hemoglobin subunit epsilon (human)
Definition A hemoglobin subunit epsilon that is encoded in the genome of human.
Short Label hHBE1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P02100 (HBE1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S14 Phosphorylation PhosphoSitePlus   UniProt 23186163
S17 Phosphorylation PhosphoSitePlus
K18 Ubiquitination PhosphoSitePlus
Y36 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
T39 Phosphorylation PhosphoSitePlus
S50 Phosphorylation PhosphoSitePlus
S51 Phosphorylation PhosphoSitePlus   UniProt 23186163
K60 Acetylation PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
K66 Acetylation PhosphoSitePlus
K67 Ubiquitination PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus
K77 Acetylation PhosphoSitePlus
K77 Ubiquitination PhosphoSitePlus
K83 Acetylation PhosphoSitePlus
K83 Ubiquitination PhosphoSitePlus
K145 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S17 R17 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T39 P39 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S50 L50 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
K60 E60 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K66 R66 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K67 N67 Biomuta DOID:363 / uterine cancer [ icgc ]
S71 T71 Biomuta [ cosmic ]
S71 F71 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ]
K83 R83 Biomuta DOID:10534 / stomach cancer [ cosmic ]