iPTMnet Report for P01889 (HLA-B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P01889 / HLAB_HUMAN
Protein Name HLA class I histocompatibility antigen, B alpha chain precursor
Gene Name Name: HLA-B
Synonyms:HLAB;
Organism Homo sapiens (Human)

PRO ID PR:P01889
DAG View
PRO Name HLA class I histocompatibility antigen, B alpha chain (human)
Definition An MHC class I histocompatibility antigen B alpha chain that is encoded in the genome of human.
Short Label hHLA-B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P01889 (HLA-B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y51 Phosphorylation PhosphoSitePlus
R59 Methylation IEDB 34433824
Y83 Phosphorylation PhosphoSitePlus
R86 Methylation PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
N110 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 19159218, ...24190977
Y123 Phosphorylation IEDB   PhosphoSitePlus 34433824
R135 Methylation PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
Y147 Phosphorylation PhosphoSitePlus
R155 Methylation PhosphoSitePlus
T158 O-Glycosylation GlyGen 30459171
T158 Phosphorylation PhosphoSitePlus
T167 Phosphorylation PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
C188 Methylation IEDB 31844290
Y195 Phosphorylation PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
K202 Ubiquitination PhosphoSitePlus
K210 Ubiquitination PhosphoSitePlus
T211 Phosphorylation PhosphoSitePlus
S219 Phosphorylation PhosphoSitePlus
C227 Methylation IEDB 31844290
C227 Phosphorylation IEDB 34433824
K267 Methylation PhosphoSitePlus
K267 Ubiquitination PhosphoSitePlus
S275 Phosphorylation PhosphoSitePlus
C283 Methylation IEDB 31844290
K292 Ubiquitination PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
K340 Ubiquitination PhosphoSitePlus
S343 Phosphorylation PhosphoSitePlus
Y344 Phosphorylation P12931 (SRC) HPRD   phospho.ELM   PhosphoSitePlus 1956339, 6304688
S350 Phosphorylation phospho.ELM   PhosphoSitePlus 6430898
S352 Phosphorylation PhosphoSitePlus
S356 Phosphorylation PhosphoSitePlus
S359 Phosphorylation HPRD   PhosphoSitePlus 20166139, 6430898
T361 Phosphorylation HPRD   PhosphoSitePlus 20166139


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y51 C51 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
R86 G86 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y123 S123 Biomuta [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
Y123 F123 Biomuta [ cosmic ] DOID:1324 / lung cancer [ icgc ]
Y123 C123 Biomuta DOID:1324 / lung cancer [ icgc ]
Y147 D147 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R155 S155 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T167 I167 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T167 S167 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
C188 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y195 H195 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ]
K202 T202 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic, icgc ] DOID:1781 / thyroid cancer [ icgc ]
S219 C219 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
C227 * Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
C283 Y283 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
C283 R283 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K292 E292 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:1324 / lung cancer [ icgc ] DOID:1781 / thyroid gland cancer [ cosmic ]
K335 N335 Biomuta DOID:5041 / esophageal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
Y344 C344 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S352 R352 Biomuta DOID:4159 / skin cancer [ cosmic ]