Protein Information

Cytoscape View


UniProt AC / UniProt ID P01877 / IGHA2_HUMAN
Protein Name Immunoglobulin heavy constant alpha 2
Gene Name Name: IGHA2
Organism Homo sapiens (Human)

PRO ID PR:P01877
DAG View
PRO Name immunoglobulin heavy constant alpha 2 (human)
Definition An immunoglobulin heavy constant alpha 2 that is encoded in the genome of human.
Short Label hIGHA2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P01877 (IGHA2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N47 N-Glycosylation GlyGen   UniProt 29741879, 24766575, 29671580, ...30659065, 18780401
N92 N-Glycosylation GlyGen   UniProt 29741879, 19139490, 29671580, ...30659065, 18780401
N131 N-Glycosylation GlyGen   UniProt 24530628, 18514042, 14760718, ...24841998, 18780401, 29741879, 29671580
K155 Ubiquitination PhosphoSitePlus
N205 N-Glycosylation GlyGen   UniProt 24530628, 30237853, 32125861, ...18514042, 14760718, 15084671, 19139490, 24841998, 16740002, 18780401, 29741879, 24766575, 29671580, 30659065
K245 Ubiquitination PhosphoSitePlus
K262 Ubiquitination PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
K314 Ubiquitination PhosphoSitePlus
N327 N-Glycosylation GlyGen   UniProt 29741879, 19139490, 29671580, ...16740002, 18780401


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N47 K47 Biomuta DOID:2531 / hematologic cancer [ icgc ]
N47 D47 Biomuta DOID:9256 / colorectal cancer [ icgc ]
N47 S47 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K245 N245 Biomuta DOID:363 / uterine cancer [ tcga ]
K262 T262 Biomuta DOID:1909 / melanoma [ icgc, tcga ]