Protein Information

Cytoscape View

UniProt AC / UniProt ID P01876 / IGHA1_HUMAN
Protein Name Immunoglobulin heavy constant alpha 1
Gene Name Name: IGHA1
Organism Homo sapiens (Human)

PRO ID PR:P01876
DAG View
PRO Name immunoglobulin heavy constant alpha 1 (human)
Definition An immunoglobulin heavy constant alpha 1 that is encoded in the genome of human.
Short Label hIGHA1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P01876 (IGHA1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
K88 Ubiquitination PhosphoSitePlus
N144 N-Glycosylation UniProt 15084671, 19139490, 19838169, ...22171320
K168 Ubiquitination PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
T201 Phosphorylation PhosphoSitePlus
C204 S-Nitrosylation dbSNO 25040305
K212 Ubiquitination PhosphoSitePlus
C250 S-Nitrosylation dbSNO 25040305
K258 Ubiquitination PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
K306 Ubiquitination PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
C313 S-Nitrosylation dbSNO 25040305
K327 Ubiquitination PhosphoSitePlus
T328 Phosphorylation PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
N340 N-Glycosylation UniProt 19139490

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N144 K144 Biomuta DOID:363 / uterine cancer [ tcga ]
K168 N168 Biomuta DOID:11934 / head and neck cancer [ tcga ]
K200 N200 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
T201 N201 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K258 N258 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
K275 T275 Biomuta DOID:1909 / melanoma [ tcga ]
K307 N307 Biomuta DOID:1324 / lung cancer [ tcga ]
C313 Y313 Biomuta DOID:2531 / hematologic cancer [ icgc ]
K335 E335 Biomuta DOID:2531 / hematologic cancer [ icgc, tcga ]