Protein Information

Cytoscape View


UniProt AC / UniProt ID P01859 / IGHG2_HUMAN
Protein Name Immunoglobulin heavy constant gamma 2
Gene Name Name: IGHG2
Organism Homo sapiens (Human)

PRO ID PR:P01859
DAG View
PRO Name immunoglobulin heavy constant gamma 2 (human)
Definition An immunoglobulin heavy constant gamma 2 that is encoded in the genome of human.
Short Label hIGHG2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P01859 (IGHG2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C14 S-Nitrosylation dbSNO 25040305
T18 Phosphorylation PhosphoSitePlus
S21 Phosphorylation PhosphoSitePlus
T22 Phosphorylation PhosphoSitePlus
C27 S-Nitrosylation dbSNO 25040305
T129 Phosphorylation PhosphoSitePlus
S133 Phosphorylation PhosphoSitePlus
N176 N-Glycosylation UniProt 15084671, 19139490, 19159218
K196 Methylation PhosphoSitePlus
K201 Acetylation PhosphoSitePlus
S243 Phosphorylation PhosphoSitePlus
T245 Phosphorylation PhosphoSitePlus
C246 S-Nitrosylation dbSNO 25040305
C304 S-Nitrosylation dbSNO 25040305
S319 Phosphorylation PhosphoSitePlus
S321 Phosphorylation PhosphoSitePlus
S323 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S21 T21 Biomuta DOID:2531 / hematologic cancer [ icgc, tcga ]
S21 N21 Biomuta DOID:1324 / lung cancer [ tcga ] DOID:2531 / hematologic cancer [ tcga ]
C27 * Biomuta DOID:2531 / hematologic cancer [ icgc ]
T129 I129 Biomuta DOID:2531 / hematologic cancer [ tcga ]
S243 G243 Biomuta DOID:10534 / stomach cancer [ tcga ]
C304 Y304 Biomuta DOID:2531 / hematologic cancer [ icgc ]