Protein Information

Cytoscape View


UniProt AC / UniProt ID P01730 / CD4_HUMAN
Protein Name T-cell surface glycoprotein CD4 precursor
Gene Name Name: CD4
Organism Homo sapiens (Human)

PRO ID PR:P01730
DAG View
PRO Name T-cell surface glycoprotein CD4 (human)
Definition A CD4 molecule that is encoded in the genome of human.
Short Label hCD4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P01730 (CD4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S67 Phosphorylation PhosphoSitePlus
T70 Phosphorylation PhosphoSitePlus
S74 Phosphorylation PhosphoSitePlus
N296 N-Glycosylation GlyGen 2001369, 2592374, 19159218, ...2209609
N325 N-Glycosylation GlyGen 2001369, 2592374, 2209609
S433 Phosphorylation P17252 (PRKCA) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 28874665, 2105883, 1674746, ...15494497
K436 Ubiquitination PhosphoSitePlus
S440 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   UniProt 2105883, 15494497
K453 Ubiquitination PhosphoSitePlus
S456 Phosphorylation UniProt 2105883


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000036630 (hCD4/iso:1/Phos:1) Interaction PR:000003229 (env/Clv:gp120/GlycoRes+) PRO 3259291
PR:P01730 (hCD4) Interaction PR:P05879 (env (HIV-1 M:B_CDC-451)) PRO 9269777


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S456 I456 Biomuta DOID:363 / uterine cancer [ tcga ]
S456 N456 Biomuta DOID:10283 / prostate cancer [ cosmic ]