iPTMnet Report for P01730 (CD4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P01730 / CD4_HUMAN
Protein Name T-cell surface glycoprotein CD4 precursor
Gene Name Name: CD4
Organism Homo sapiens (Human)

PRO ID PR:P01730
DAG View
PRO Name T-cell surface glycoprotein CD4 (human)
Definition A CD4 molecule that is encoded in the genome of human.
Short Label hCD4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P01730 (CD4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S67 Phosphorylation PhosphoSitePlus
T70 Phosphorylation PhosphoSitePlus
S74 Phosphorylation PhosphoSitePlus
N296 N-Glycosylation GlyGen 2001369, 2592374, 19159218, ...2209609
N325 N-Glycosylation GlyGen 2001369, 2592374, 2209609
S433 Phosphorylation P17252 (PRKCA) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 28874665, 2105883, 1674746, ...15494497
K436 Ubiquitination PhosphoSitePlus
S440 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   UniProt 2105883, 15494497
K453 Ubiquitination PhosphoSitePlus
S456 Phosphorylation UniProt 2105883
Site PTM Type PTM Enzyme Score Source PMID
N296 N-Glycosylation PRO 2592374
N325 N-Glycosylation PRO 2592374


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000036630 (hCD4/iso:1/Phos:1) Interaction PR:000003229 (env/Clv:gp120/GlycoRes+) PRO 3259291
PR:P01730 (hCD4) Interaction PR:P05879 (env (HIV-1 M:B_CDC-451)) PRO 9269777


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K453 R453 Biomuta DOID:4159 / skin cancer [ cosmic ]
S456 I456 Biomuta DOID:363 / uterine cancer [ icgc ]
S456 N456 Biomuta DOID:10283 / prostate cancer [ cosmic ]