iPTMnet Report for P01130 (LDLR)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P01130 / LDLR_HUMAN
Protein Name Low-density lipoprotein receptor precursor
Gene Name Name: LDLR
Organism Homo sapiens (Human)

PRO ID PR:P01130
DAG View
PRO Name low-density lipoprotein receptor (human)
Definition A low-density lipoprotein receptor that is encoded in the genome of human.
Short Label hLDLR
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P01130 (LDLR) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K38 Ubiquitination PhosphoSitePlus
C75 Methylation IEDB 31844290
T108 O-Glycosylation GlyGen 30459171
S110 Phosphorylation PhosphoSitePlus
N156 N-Glycosylation GlyGen   UniProt 19520913
T235 O-Glycosylation GlyGen 30459171
N272 N-Glycosylation GlyGen   UniProt 29741879, 19520913, 29391424, ...24190977
K390 Ubiquitination PhosphoSitePlus
S447 Phosphorylation IEDB 35494241
Y465 Phosphorylation PhosphoSitePlus
S470 Phosphorylation PhosphoSitePlus
N515 N-Glycosylation GlyGen 29391424
S517 Phosphorylation PhosphoSitePlus
K596 Ubiquitination PhosphoSitePlus
K603 Ubiquitination PhosphoSitePlus
N657 N-Glycosylation GlyGen   UniProt 16335952, 29741879, 12754519, ...19159218, 24190977
N665 N-Glycosylation GlyGen 29391424
T713 Phosphorylation PhosphoSitePlus
T721 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T724 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
S725 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T726 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
K730 Ubiquitination PhosphoSitePlus
S732 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S733 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T734 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T738 O-Glycosylation GlyGen   PhosphoSitePlus 33214551, 29351928, 34019948, ...23584533, 28510447
T741 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T742 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T743 O-Glycosylation GlyGen   PhosphoSitePlus 33214551, 29351928, 34019948, ...23584533, 28510447
S750 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T766 O-Glycosylation GlyGen 25813380
S768 O-Glycosylation GlyGen 30459171, 25813380
S820 Phosphorylation PhosphoSitePlus
Y828 Phosphorylation PhosphoSitePlus
K830 Ubiquitination PhosphoSitePlus
Y845 Phosphorylation phospho.ELM   PhosphoSitePlus 15592455
S846 Phosphorylation PhosphoSitePlus
Y847 Phosphorylation PhosphoSitePlus
S849 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S397 Phosphorylation HPRD 20068231
T404 Phosphorylation HPRD 20068231
Y845 Phosphorylation HPRD 15592455, 17016520, 17389395, ...19901323
Y847 Phosphorylation HPRD 17016520


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T108 M108 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ]
S110 F110 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S110 T110 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T235 A235 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
N272 T272 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
N272 K272 Biomuta DOID:184 / bone cancer [ cosmic ]
S517 Y517 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K603 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K603 T603 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T724 S724 Biomuta DOID:1324 / lung cancer [ cosmic ]
T724 K724 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S725 Y725 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
T726 I726 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S768 F768 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S846 N846 Biomuta DOID:10534 / stomach cancer [ cosmic ]