Protein Information

Cytoscape View


UniProt AC / UniProt ID P01116 / RASK_HUMAN
Protein Name GTPase KRas precursor
Gene Name Name: KRAS
Synonyms:KRAS2,RASK2;
Organism Homo sapiens (Human)

PRO ID PR:P01116
DAG View
PRO Name GTPase KRas (human)
Definition A GTPase KRas that is encoded in the genome of human.
Short Label hKRAS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P01116 (KRAS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T2 Phosphorylation PhosphoSitePlus
Y4 Phosphorylation PhosphoSitePlus
Y32 Phosphorylation PhosphoSitePlus   RLIMS-P 31419909, 30644389
S39 Phosphorylation PhosphoSitePlus
Y40 Phosphorylation PhosphoSitePlus
Y64 Phosphorylation PhosphoSitePlus   RLIMS-P 30644389
S89 Phosphorylation PhosphoSitePlus
Y96 Phosphorylation PhosphoSitePlus
K101 Acetylation PhosphoSitePlus
K104 Acetylation PhosphoSitePlus   UniProt 22711838
K104 Ubiquitination PhosphoSitePlus
S106 Phosphorylation PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
K128 Acetylation PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
Y137 Phosphorylation PhosphoSitePlus
T144 Phosphorylation PhosphoSitePlus
K147 Acetylation PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
T148 Phosphorylation PhosphoSitePlus
Y157 Phosphorylation PhosphoSitePlus
K170 Ubiquitination UniProt 30442762
Site PTM Type PTM Enzyme Score Source PMID
K104 Acetylation PhosphoSitePlus
T148 Phosphorylation PhosphoSitePlus
Y157 Phosphorylation PhosphoSitePlus
T158 Phosphorylation PhosphoSitePlus
K179 Acetylation PhosphoSitePlus
S181 Phosphorylation Q04759 (PRKCQ) , P17252 (PRKCA) PhosphoSitePlus 16483930, 20802526


P01116 (KRAS) as PTM Enzyme



Substrate Site Score Source PMID
Q13233 (MAP3K1) S67 Signor 12228228, 8649450


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P01116 (KRAS) Y64 Q9Y6X8 (ZHX2) decreased_association eFIP 30644389


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y64 H64 Biomuta DOID:1909 / melanoma [ cosmic ]
S89 * Biomuta DOID:363 / uterine cancer [ cosmic ]
K117 R117 Biomuta DOID:2531 / hematologic cancer [ icgc ]
K117 N117 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ tcga ] DOID:2531 / hematologic cancer [ icgc ]
K170 Q170 Biomuta DOID:1909 / melanoma [ cosmic ]
K170 N170 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]