iPTMnet Report P01116 KRAS

Protein Information

UniProt AC / UniProt ID	P01116 / RASK_HUMAN
Protein Name	GTPase KRas precursor
Gene Name	Name: KRAS Synonyms:KRAS2,RASK2;
Organism	Homo sapiens (Human)

PRO ID	PR:P01116 DAG View
PRO Name	GTPase KRas (human)
Definition	A GTPase KRas that is encoded in the genome of human.
Short Label	hKRAS
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P01116 (KRAS) as Substrate

Expanded View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position T2 Y4 K5 Y32 T35 S39 Y40 K42 Y64 S89 Y96 K101 K104 S106 K117 K128 Y137 T144 K147 T148 Y157 K170	PTM Type Select all Acetylation Methylation O-Glycosylation Phosphorylation Sumoylation Ubiquitination	Score Select all 1 2 3 4	Source Select all PhosphoSitePlus RLIMS-P UniProt	PMID
T2	Phosphorylation	score1	PhosphoSitePlus
Y4	Phosphorylation	score1	PhosphoSitePlus
K5	Methylation	score1	PhosphoSitePlus
Y32	Phosphorylation	score3	PhosphoSitePlus RLIMS-P	30644389
T35	O-Glycosylation	score2	UniProt	19744486
S39	Phosphorylation	score1	PhosphoSitePlus
Y40	Phosphorylation	score1	PhosphoSitePlus
K42	Sumoylation	score1	PhosphoSitePlus
Y64	Phosphorylation	score4	PhosphoSitePlus RLIMS-P	30644389, 33680360
S89	Phosphorylation	score1	PhosphoSitePlus
Y96	Phosphorylation	score1	PhosphoSitePlus
K101	Acetylation	score1	PhosphoSitePlus
K104	Acetylation	score3	PhosphoSitePlus UniProt	22711838
K104	Ubiquitination	score1	PhosphoSitePlus
S106	Phosphorylation	score1	PhosphoSitePlus
K117	Ubiquitination	score1	PhosphoSitePlus
K128	Acetylation	score1	PhosphoSitePlus
K128	Ubiquitination	score1	PhosphoSitePlus
Y137	Phosphorylation	score1	PhosphoSitePlus
T144	Phosphorylation	score1	PhosphoSitePlus
K147	Acetylation	score1	PhosphoSitePlus
K147	Ubiquitination	score1	PhosphoSitePlus
T148	Phosphorylation	score1	PhosphoSitePlus
Y157	Phosphorylation	score1	PhosphoSitePlus
K170	Ubiquitination	score2	UniProt	30442762

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position K104 K147 T148 Y157 T158 K179 S181 K182 K184 C185	PTM Type Select all Acetylation Farnesylation Methylation Phosphorylation Ubiquitination	PTM Enzyme	Score Select all 1 2 3	Source Select all IntAct PhosphoSitePlus	PMID
K104	Acetylation		score1	PhosphoSitePlus
K104	Ubiquitination		score1	PhosphoSitePlus
K147	Ubiquitination		score1	PhosphoSitePlus
T148	Phosphorylation		score1	PhosphoSitePlus
Y157	Phosphorylation		score1	PhosphoSitePlus
T158	Phosphorylation		score1	PhosphoSitePlus
K179	Acetylation		score1	PhosphoSitePlus
S181	Phosphorylation	Q04759 (PRKCQ) , P17252 (PRKCA)	score3	PhosphoSitePlus	16483930, 20802526
K182	Methylation		score1	PhosphoSitePlus
K184	Methylation		score1	PhosphoSitePlus
C185	Farnesylation		score2	IntAct	23698361

P01116 (KRAS) as PTM Enzyme

Protein as Phosphorylation Enzyme

Search:

	Substrate Select all Q13233 (MAP3K1)	Site Select all By amino acid All Serine By position S67	Score Select all 2	Source Select all Signor	PMID
	Q13233 (MAP3K1)	S67	score2	Signor	12228228, 8649450

PTM-dependent PPI

Search:

	PTM type Select all Phosphorylation	Substrate Select all P01116 (KRAS)	Site Select all By amino acid All Tyrosine By position Y64	Interactant Select all Q9H1B5 (XYLT2) Q9Y6X8 (ZHX2)	Association type Select all decreased_association unknown	Source Select all eFIP	PMID
	Phosphorylation	P01116 (KRAS)	Y64	Q9Y6X8 (ZHX2)	decreased_association	eFIP	30644389
	Phosphorylation	P01116 (KRAS)	Y64	Q9H1B5 (XYLT2)	unknown	eFIP	33680360

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position T2 K5 T35 S39 Y64 S89 K104 K117 T144 K147 Y157 K170 S181 K182 C185	Variant Select all * A35 C157 D64 E117 E147 E182 E5 H64 I2 I35 N104 N117 N147 N170 N5 N64 P144 P181 Q170 R117 R185 R5 S185 T147 Y39	Source Select all Biomuta	Disease [Sample source] Select all DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:1793 / pancreatic cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, cosmic ] DOID:9256 / colorectal cancer [ cosmic, cosmic, cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:4362 / cervical cancer [ cosmic ] DOID:4362 / cervical cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc, tcga ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ] DOID:3119 / gastrointestinal system cancer [ cosmic ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ] [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
T2	I2	Biomuta	DOID:4159 / skin cancer [ cosmic ]
K5	N5	Biomuta	DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
K5	E5	Biomuta	DOID:9256 / colorectal cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
K5	R5	Biomuta	DOID:1793 / pancreatic cancer [ cosmic ]
T35	A35	Biomuta	DOID:5041 / esophageal cancer [ cosmic, icgc ]
T35	I35	Biomuta	DOID:9256 / colorectal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S39	Y39	Biomuta	DOID:4362 / cervical cancer [ cosmic ]
Y64	D64	Biomuta	DOID:1793 / pancreatic cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
Y64	H64	Biomuta	DOID:4362 / cervical cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
Y64	N64	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
S89	*	Biomuta	DOID:363 / uterine cancer [ cosmic, cosmic ] DOID:9256 / colorectal cancer [ cosmic, cosmic, cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic ]
K104	N104	Biomuta	DOID:363 / uterine cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
K117	R117	Biomuta	[ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
K117	E117	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
K117	N117	Biomuta	[ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc, tcga ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ] DOID:3119 / gastrointestinal system cancer [ cosmic ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
T144	P144	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
K147	E147	Biomuta	DOID:9256 / colorectal cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic ]
K147	N147	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ]
K147	T147	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
Y157	C157	Biomuta	DOID:1793 / pancreatic cancer [ cosmic, icgc ]
K170	Q170	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
K170	N170	Biomuta	DOID:3571 / liver cancer [ cosmic ]
S181	*	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S181	P181	Biomuta	DOID:363 / uterine cancer [ cosmic ]
K182	E182	Biomuta	DOID:1781 / thyroid gland cancer [ cosmic ]
C185	R185	Biomuta	DOID:5041 / esophageal cancer [ cosmic ]
C185	S185	Biomuta	DOID:1324 / lung cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P01116 (KRAS)

Protein Information

Interactive Sequence View

P01116 (KRAS) as Substrate

P01116 (KRAS) as PTM Enzyme

PTM-dependent PPI

PTM sites affected in variants