iPTMnet Report P01112 HRAS

Protein Information

UniProt AC / UniProt ID	P01112 / RASH_HUMAN
Protein Name	GTPase HRas precursor
Gene Name	Name: HRAS Synonyms:HRAS1;
Organism	Homo sapiens (Human)

PRO ID	PR:P01112 DAG View
PRO Name	GTPase HRas (human)
Definition	A GTPase HRas that is encoded in the genome of human.
Short Label	hHRAS
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P01112 (HRAS) as Substrate

Condensed View

Site	PTM Type	PTM Enzyme	Score	Source	PMID
K5	Methylation		score1	PhosphoSitePlus
Y32	Phosphorylation		score4	PhosphoSitePlus RLIMS-P Signor	25157176, 36458814
Y32	Phosphorylation	P12931 (SRC)	score3	PhosphoSitePlus Signor	25157176
T35	O-Glycosylation		score4	GlyGen UniProt	36580660, 9632667, 22665487, ...8626575, 19744486, 8626586
T35	Phosphorylation		score3	phospho.ELM PhosphoSitePlus	9264402
S39	Phosphorylation		score1	PhosphoSitePlus
Y40	Phosphorylation		score1	PhosphoSitePlus
Y64	Phosphorylation		score2	PhosphoSitePlus	25157176
Y64	Phosphorylation	P12931 (SRC)	score2	PhosphoSitePlus	25157176
C80	S-Nitrosylation		score0	dbSNO	24105792
Y96	Phosphorylation		score2	PhosphoSitePlus	25157176
Y96	Phosphorylation	P12931 (SRC)	score2	PhosphoSitePlus	25157176
K117	Ubiquitination		score1	PhosphoSitePlus
C118	S-Nitrosylation		score2	dbSNO	24105792, 9020151
Y137	Phosphorylation		score2	PhosphoSitePlus	25999467
Y137	Phosphorylation	P00519 (ABL1)	score2	PhosphoSitePlus	25999467
Y137	Phosphorylation	P42684 (ABL2)	score2	PhosphoSitePlus	25999467
T144	Phosphorylation		score2	PhosphoSitePlus	22494971
T144	Phosphorylation	P49841 (GSK3B)	score2	PhosphoSitePlus	22494971
S145	Phosphorylation		score1	PhosphoSitePlus
K147	Methylation		score1	PhosphoSitePlus
K147	Ubiquitination		score1	PhosphoSitePlus
T148	Phosphorylation		score2	PhosphoSitePlus	22494971
T148	Phosphorylation	P49841 (GSK3B)	score2	PhosphoSitePlus	22494971
Y157	Phosphorylation		score1	PhosphoSitePlus
T158	Phosphorylation		score1	PhosphoSitePlus
K170	Ubiquitination		score3	PhosphoSitePlus UniProt	30442762
C181	S-Nitrosylation		score0	dbSNO	24105792
S183	Phosphorylation		score1	PhosphoSitePlus
S189	Farnesylation		score2	IntAct	11335720

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S136	Phosphorylation		score0	HPRD	20068231
	S145	Phosphorylation		score0	HPRD	20068231

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S136	Phosphorylation		score0	HPRD	20068231
	S145	Phosphorylation		score0	HPRD	20068231

PTM-dependent PPI

	PTM type	Substrate	Site	Interactant	Association type	Source	PMID
	Phosphorylation	P04049 (RAF1)	S43	P01112 (HRAS)	decreased_association	eFIP	9001246

PTM sites affected in variants

Site	Variant	Source	Disease [Sample source]
Y32	C32	Biomuta	DOID:4159 / skin cancer [ cosmic ]
Y32	*	Biomuta	DOID:5041 / esophageal cancer [ cosmic ]
Y64	H64	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
C80	Y80	Biomuta	DOID:4159 / skin cancer [ cosmic ] DOID:11615 / penile cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
K117	E117	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
K117	N117	Biomuta	DOID:1612 / breast cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
C118	Y118	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
Y137	D137	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S145	L145	Biomuta	DOID:11615 / penile cancer [ cosmic ]
S145	*	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic ]
K147	N147	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
T148	A148	Biomuta	DOID:4159 / skin cancer [ cosmic ]
K170	T170	Biomuta	DOID:1612 / breast cancer [ cosmic ]
K170	R170	Biomuta	[ cosmic ]
K170	N170	Biomuta	DOID:1324 / lung cancer [ cosmic ]
C181	Y181	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P01112 (HRAS)

Protein Information

Interactive Sequence View

P01112 (HRAS) as Substrate

PTM-dependent PPI

PTM sites affected in variants