iPTMnet Report for P01031 (C5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P01031 / CO5_HUMAN
Protein Name Complement C5 precursor
Gene Name Name: C5
Synonyms:CPAMD4;
Organism Homo sapiens (Human)

PRO ID PR:P01031
DAG View
PRO Name complement C5 (human)
Definition A complement C5 that is encoded in the genome of human.
Short Label hC5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P01031 (C5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S114 Phosphorylation PhosphoSitePlus
T120 Phosphorylation PhosphoSitePlus
Y121 Phosphorylation PhosphoSitePlus
K276 Ubiquitination PhosphoSitePlus
S662 Phosphorylation PhosphoSitePlus
Y690 Phosphorylation PhosphoSitePlus
S693 Phosphorylation PhosphoSitePlus
Y700 Phosphorylation PhosphoSitePlus
S719 Phosphorylation PhosphoSitePlus
T729 Phosphorylation PhosphoSitePlus
S736 Phosphorylation PhosphoSitePlus
N741 N-Glycosylation GlyGen   UniProt 16335952, 18536718, 23090970, ...29391424
S743 Phosphorylation PhosphoSitePlus
N911 N-Glycosylation GlyGen   UniProt 16335952, 18536718, 21217642
T971 Phosphorylation IEDB   PhosphoSitePlus 35494241
S993 Phosphorylation IEDB 35494241
N1115 N-Glycosylation GlyGen 29671580
K1305 Ubiquitination PhosphoSitePlus
Y1317 Phosphorylation PhosphoSitePlus
T1599 Phosphorylation PhosphoSitePlus
N1630 N-Glycosylation GlyGen   UniProt 16335952, 29391424
Site PTM Type PTM Enzyme Score Source PMID
N1115 N-Glycosylation PRO 29671580


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S114 A114 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K276 T276 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y700 H700 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y700 C700 Biomuta DOID:1319 / brain cancer [ cosmic ]
S719 N719 Biomuta DOID:1319 / brain cancer [ cosmic ]
S743 C743 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T971 I971 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S993 I993 Biomuta DOID:4159 / skin cancer [ cosmic ]