iPTMnet Report for P01024 (C3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P01024 / CO3_HUMAN
Protein Name Complement C3 precursor
Gene Name Name: C3
Synonyms:CPAMD1;
Organism Homo sapiens (Human)

PRO ID PR:P01024
DAG View
PRO Name complement C3 (human)
Definition A complement C3 that is encoded in the genome of human.
Short Label hC3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P01024 (C3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T4 Phosphorylation IEDB 32387766
S8 Phosphorylation IEDB 32387766
S38 Phosphorylation UniProt 26091039
S70 Phosphorylation UniProt 26091039
N85 N-Glycosylation GlyGen   UniProt 16335952, 34725484, 24530628, ...32125861, 19159218, 24190977, 23090970, 17684013, 16263699, 29391424, 24279413, 2579379, 18514042, 17051150, 29741879, 12754519, 29671580, 4077844
S283 Phosphorylation PhosphoSitePlus
S287 Phosphorylation PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
S297 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19824718, 26091039
S303 Phosphorylation PhosphoSitePlus   UniProt 26091039
K305 Ubiquitination PhosphoSitePlus
S520 Phosphorylation IEDB 32387766
C627 Methylation IEDB 31844290
S672 Phosphorylation PhosphoSitePlus   UniProt 26091039
T676 Phosphorylation PhosphoSitePlus
Y686 Phosphorylation PhosphoSitePlus
C720 Methylation IEDB 31844290
S742 Phosphorylation phospho.ELM   PhosphoSitePlus 1756717
T885 Phosphorylation PhosphoSitePlus
S922 Phosphorylation PhosphoSitePlus
S928 Phosphorylation PhosphoSitePlus
N939 N-Glycosylation GlyGen   UniProt 16335952, 17051150, 14760718, ...29671580, 29741879
S968 Phosphorylation UniProt 26091039
T985 O-Glycosylation GlyGen 30459171
T1031 Phosphorylation phospho.ELM   PhosphoSitePlus 10358196
Y1194 Phosphorylation PhosphoSitePlus
S1315 Phosphorylation PhosphoSitePlus
S1321 Phosphorylation PhosphoSitePlus   UniProt 26091039
T1341 Phosphorylation PhosphoSitePlus
S1343 Phosphorylation PhosphoSitePlus
Y1480 Phosphorylation PhosphoSitePlus
C1537 Methylation IEDB 31844290
S1571 Phosphorylation HPRD 19824718
S1573 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19824718, 26091039
S1586 Phosphorylation HPRD   PhosphoSitePlus 20068231
N1617 N-Glycosylation GlyGen   UniProt 16335952, 29671580
Site PTM Type PTM Enzyme Score Source PMID
N85 N-Glycosylation PRO 24279413, 29671580, 4077844
N939 N-Glycosylation PRO 29741879, 29671580
N1617 N-Glycosylation PRO 29671580


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S283 F283 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S297 L297 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S303 N303 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S672 F672 Biomuta DOID:4159 / skin cancer [ cosmic ]
S672 P672 Biomuta DOID:1319 / brain cancer [ cosmic ]
T676 M676 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
Y686 H686 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S742 G742 Biomuta DOID:1324 / lung cancer [ cosmic ]
S742 N742 Biomuta DOID:363 / uterine cancer [ cosmic ]
S928 F928 Biomuta DOID:4159 / skin cancer [ cosmic ]
S928 A928 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S1321 L1321 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T1341 N1341 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S1343 L1343 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y1480 H1480 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S1573 * Biomuta DOID:5041 / esophageal cancer [ cosmic ]