Protein Information

Cytoscape View


UniProt AC / UniProt ID P01024 / CO3_HUMAN
Protein Name Complement C3 precursor
Gene Name Name: C3
Synonyms:CPAMD1;
Organism Homo sapiens (Human)

PRO ID PR:P01024
DAG View
PRO Name complement C3 (human)
Definition A complement C3 that is encoded in the genome of human.
Short Label hC3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P01024 (C3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S38 Phosphorylation UniProt 26091039
S70 Phosphorylation UniProt 26091039
N85 N-Glycosylation UniProt 16335952, 19159218, 17684013, ...16263699, 2579379, 17051150, 12754519
S283 Phosphorylation PhosphoSitePlus
S287 Phosphorylation PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
S297 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19824718, 26091039
S303 Phosphorylation PhosphoSitePlus   UniProt 26091039
K305 Ubiquitination PhosphoSitePlus
S672 Phosphorylation PhosphoSitePlus   UniProt 26091039
T676 Phosphorylation PhosphoSitePlus
Y686 Phosphorylation PhosphoSitePlus
S742 Phosphorylation phospho.ELM   PhosphoSitePlus 1756717
T885 Phosphorylation PhosphoSitePlus
S922 Phosphorylation PhosphoSitePlus
S928 Phosphorylation PhosphoSitePlus
N939 N-Glycosylation UniProt 16335952, 17051150, 14760718
S968 Phosphorylation UniProt 26091039
T1031 Phosphorylation phospho.ELM   PhosphoSitePlus 10358196
Y1194 Phosphorylation PhosphoSitePlus
S1315 Phosphorylation PhosphoSitePlus
S1321 Phosphorylation PhosphoSitePlus   UniProt 26091039
T1341 Phosphorylation PhosphoSitePlus
S1343 Phosphorylation PhosphoSitePlus
Y1480 Phosphorylation PhosphoSitePlus
S1571 Phosphorylation HPRD 19824718
S1573 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19824718, 26091039
S1586 Phosphorylation HPRD   PhosphoSitePlus 20068231
N1617 N-Glycosylation UniProt 16335952


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S70 F70 Biomuta DOID:5041 / esophageal cancer [ tcga ]
S297 L297 Biomuta DOID:363 / uterine cancer [ tcga ]
T676 M676 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
Y686 * Biomuta DOID:3571 / liver cancer [ icgc ]
S742 G742 Biomuta DOID:1324 / lung cancer [ cosmic ]
S928 A928 Biomuta DOID:1612 / breast cancer [ icgc, tcga ]
S968 G968 Biomuta DOID:363 / uterine cancer [ tcga ]
S1321 L1321 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T1341 N1341 Biomuta DOID:2394 / ovarian cancer [ icgc, tcga ] DOID:2994 / germ cell cancer [ cosmic ]
S1343 L1343 Biomuta DOID:9256 / colorectal cancer [ icgc ]
Y1480 H1480 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S1573 L1573 Biomuta DOID:1319 / brain cancer [ icgc ]