Protein Information

Cytoscape View

UniProt AC / UniProt ID P01011 / AACT_HUMAN
Protein Name Alpha-1-antichymotrypsin precursor
Gene Name Name: SERPINA3
Organism Homo sapiens (Human)

PRO ID PR:P01011
DAG View
PRO Name alpha-1-antichymotrypsin (human)
Definition An alpha-1-antichymotrypsin that is encoded in the genome of human.
Short Label hSERPINA3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P01011 (SERPINA3) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
N33 N-Glycosylation UniProt 16335952
T35 Phosphorylation PhosphoSitePlus
N93 N-Glycosylation UniProt 16335952, 12754519, 14760718, ...19159218
N106 N-Glycosylation UniProt 16335952, 12754519, 19159218
N127 N-Glycosylation UniProt 16335952, 19159218
K158 Acetylation PhosphoSitePlus
K177 Acetylation PhosphoSitePlus
N186 N-Glycosylation UniProt 16335952
K191 Acetylation PhosphoSitePlus
S201 Phosphorylation PhosphoSitePlus
T203 Phosphorylation PhosphoSitePlus
K235 Acetylation PhosphoSitePlus
K236 Acetylation PhosphoSitePlus
K237 Acetylation PhosphoSitePlus
C261 S-Nitrosylation dbSNO 25040305
N271 N-Glycosylation UniProt 16335952, 19159218
S273 Phosphorylation PhosphoSitePlus
T295 Phosphorylation PhosphoSitePlus
S302 Phosphorylation PhosphoSitePlus
T338 Phosphorylation PhosphoSitePlus
T347 O-Glycosylation PhosphoSitePlus
T347 Phosphorylation PhosphoSitePlus
S384 Phosphorylation PhosphoSitePlus
K416 Acetylation PhosphoSitePlus
K421 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
E2 Acetylation PRO


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000035634 (hSERPINA3/iso:1/InitMet-/Ac:1) acE2 PRO

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T35 I35 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
N127 S127 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
K158 N158 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
K177 N177 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S201 L201 Biomuta DOID:1909 / melanoma [ cosmic ]
T203 K203 Biomuta DOID:1324 / lung cancer [ cosmic ]
K235 N235 Biomuta DOID:3070 / malignant glioma [ cosmic, icgc, tcga ]
C261 F261 Biomuta DOID:3571 / liver cancer [ icgc ]
S302 P302 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]
S384 F384 Biomuta DOID:3070 / malignant glioma [ cosmic, icgc, tcga ]