iPTMnet Report for P01011 (SERPINA3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P01011 / AACT_HUMAN
Protein Name Alpha-1-antichymotrypsin precursor
Gene Name Name: SERPINA3
Synonyms:AACT;ORFNames:GIG24,GIG25;
Organism Homo sapiens (Human)

PRO ID PR:P01011
DAG View
PRO Name alpha-1-antichymotrypsin (human)
Definition An alpha-1-antichymotrypsin that is encoded in the genome of human.
Short Label hSERPINA3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P01011 (SERPINA3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C18 Methylation IEDB 31844290
N33 N-Glycosylation GlyGen   UniProt 16335952
T35 Phosphorylation PhosphoSitePlus
N93 N-Glycosylation GlyGen   UniProt 16335952, 24530628, 19159218, ...14760718, 2015821, 29741879, 12754519, 29671580
N106 N-Glycosylation GlyGen   UniProt 16335952, 34725484, 24530628, ...32125861, 19159218, 29391424, 24279413, 29741879, 12754519, 29671580
S118 O-Glycosylation GlyGen 22661428
N127 N-Glycosylation GlyGen   UniProt 16335952, 34725484, 32125861, ...19159218, 29391424, 2015821, 29741879, 29671580
K158 Acetylation PhosphoSitePlus
K177 Acetylation PhosphoSitePlus
N186 N-Glycosylation GlyGen   UniProt 16335952, 29741879
K191 Acetylation PhosphoSitePlus
S201 Phosphorylation PhosphoSitePlus
T203 Phosphorylation PhosphoSitePlus
K235 Acetylation PhosphoSitePlus
K236 Acetylation PhosphoSitePlus
K237 Acetylation PhosphoSitePlus
C261 S-Nitrosylation dbSNO 25040305
N271 N-Glycosylation GlyGen   UniProt 16335952, 34725484, 24530628, ...30237853, 19159218, 29391424, 32125861, 29741879, 29671580
S273 O-Glycosylation GlyGen 22661428
S273 Phosphorylation PhosphoSitePlus
T295 Phosphorylation PhosphoSitePlus
S302 Phosphorylation PhosphoSitePlus
T338 Phosphorylation PhosphoSitePlus
T347 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T347 Phosphorylation PhosphoSitePlus
S373 O-Glycosylation GlyGen 30459171
T381 O-Glycosylation GlyGen 30459171
S384 Phosphorylation PhosphoSitePlus
K416 Acetylation PhosphoSitePlus
K421 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
E2 Acetylation PRO
N93 N-Glycosylation PRO 2015821, 29671580
N106 N-Glycosylation PRO 24279413, 29671580
N127 N-Glycosylation PRO 2015821, 29671580
N271 N-Glycosylation PRO 29671580


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000035634 (hSERPINA3/iso:1/InitMet-/Ac:1) acE2 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C18 F18 Biomuta DOID:3571 / liver cancer [ cosmic ]
T35 I35 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
N93 D93 Biomuta DOID:1319 / brain cancer [ cosmic ]
S118 R118 Biomuta DOID:1319 / brain cancer [ cosmic ]
N127 S127 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K158 N158 Biomuta DOID:4362 / cervical cancer [ cosmic ]
K177 N177 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
N186 I186 Biomuta DOID:4159 / skin cancer [ cosmic ]
K191 E191 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S201 L201 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T203 K203 Biomuta DOID:1324 / lung cancer [ cosmic ]
K235 N235 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S302 P302 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S384 F384 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]