iPTMnet Report for P01009 (SERPINA1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P01009 / A1AT_HUMAN
Protein Name Alpha-1-antitrypsin precursor
Gene Name Name: SERPINA1
Synonyms:AAT,PI;ORFNames:PRO0684,PRO2209;
Organism Homo sapiens (Human)

PRO ID PR:P01009
DAG View
PRO Name alpha-1-antitrypsin (human)
Definition An alpha-1-antitrypsin that is encoded in the genome of human.
Short Label hSERPINA1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P01009 (SERPINA1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T35 O-Glycosylation GlyGen 30459171
T35 Phosphorylation PhosphoSitePlus
T37 Phosphorylation PhosphoSitePlus
S38 Phosphorylation PhosphoSitePlus   UniProt 26091039
N70 N-Glycosylation GlyGen   UniProt 16335952, 34725484, 24530628, ...16622833, 19159218, 23090970, 15084671, 14760718, 22171320, 6966283, 16263699, 19838169, 8390218, 29405331, 29741879, 12754519, 29671580, 24417605
N107 N-Glycosylation GlyGen   UniProt 16335952, 34725484, 24530628, ...16622833, 19159218, 23090970, 19139490, 6966283, 19838169, 8390218, 29405331, 29741879, 29671580, 24417605, 29427759
T109 O-Glycosylation GlyGen 30459171
T137 O-Glycosylation GlyGen 29351928
T138 O-Glycosylation GlyGen 29351928
K153 Acetylation PhosphoSitePlus
K159 Acetylation PhosphoSitePlus
K160 Acetylation PhosphoSitePlus
T168 O-Glycosylation GlyGen 30459171
Y184 Phosphorylation PhosphoSitePlus
K198 Acetylation PhosphoSitePlus
C256 Methylation IEDB 31844290
C256 S-Nitrosylation dbSNO 25040305, 22178444, 10673391
K257 Acetylation PhosphoSitePlus
K258 Acetylation PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
N271 N-Glycosylation GlyGen   UniProt 16622833, 14760718, 29391424, ...29741879, 16335952, 24530628, 32125861, 26791533, 19139490, 19838169, 24279413, 19159218, 24190977, 15084671, 8390218, 24841998, 18514042, 34725484, 30237853, 23090970, 22171320, 6966283, 29405331, 12754519, 29671580, 24417605
T273 O-Glycosylation GlyGen 30237853
K298 Acetylation PhosphoSitePlus
S307 Phosphorylation PhosphoSitePlus
S309 Phosphorylation PhosphoSitePlus
K314 Acetylation PhosphoSitePlus
S316 Phosphorylation PhosphoSitePlus
T318 Phosphorylation PhosphoSitePlus
Y321 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
T333 Phosphorylation PhosphoSitePlus
S343 Phosphorylation PhosphoSitePlus
S383 Phosphorylation PhosphoSitePlus   UniProt 24275569
N414 N-Glycosylation GlyGen 29391424
T416 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N70 N-Glycosylation PRO 8390218, 19838169, 29671580, ...22171320, 6966283
N107 N-Glycosylation PRO 8390218, 19838169, 29671580, ...6966283
N271 N-Glycosylation PRO 26791533, 22171320, 6966283, ...8390218, 19838169, 24279413, 29671580, 24841998
T333 Phosphorylation HPRD 20068231
S383 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T109 M109 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
K153 T153 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K159 N159 Biomuta DOID:363 / uterine cancer [ icgc ]
K160 N160 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
Y184 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S261 T261 Biomuta DOID:1324 / lung cancer [ cosmic ]
K298 N298 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S316 F316 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y321 N321 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S383 Y383 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]