iPTMnet Report for P01008 (SERPINC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P01008 / ANT3_HUMAN
Protein Name Antithrombin-III precursor
Gene Name Name: SERPINC1
Synonyms:AT3;ORFNames:PRO0309;
Organism Homo sapiens (Human)

PRO ID PR:P01008
DAG View
PRO Name antithrombin-III (human)
Definition An antithrombin-III that is encoded in the genome of human.
Short Label hSERPINC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P01008 (SERPINC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T10 Phosphorylation PhosphoSitePlus
S57 Phosphorylation PhosphoSitePlus
T63 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20166139, 26091039
S68 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19824718, 18702456, 24275569, ...20166139, 26091039
N128 N-Glycosylation GlyGen   UniProt 16335952, 34725484, 24530628, ...30237853, 19159218, 23090970, 14760718, 29391424, 32125861, 24279413, 29741879, 29671580
S174 Phosphorylation HPRD   PhosphoSitePlus 20068231
N187 N-Glycosylation GlyGen   UniProt 16335952, 34725484, 24530628, ...30237853, 19159218, 23090970, 14760718, 29391424, 32125861, 15084671, 19838169, 24279413, 29741879, 29671580
S214 Phosphorylation PhosphoSitePlus
N224 N-Glycosylation GlyGen   UniProt 16335952, 34725484, 23090970, ...16263699, 24841998, 29671580
Y272 Phosphorylation PhosphoSitePlus
T418 O-Glycosylation GlyGen 30459171
N460 N-Glycosylation GlyGen 29391424
Site PTM Type PTM Enzyme Score Source PMID
N128 N-Glycosylation PRO 24279413, 29671580
N187 N-Glycosylation PRO 19838169, 29671580
N224 N-Glycosylation PRO 24841998, 29671580


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S68 * Biomuta DOID:1324 / lung cancer [ cosmic ]
T418 I418 Biomuta DOID:4159 / skin cancer [ cosmic ]