iPTMnet Report for P00966 (ASS1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P00966 / ASSY_HUMAN
Protein Name Argininosuccinate synthase
Gene Name Name: ASS1
Synonyms:ASS;
Organism Homo sapiens (Human)

PRO ID PR:P00966
DAG View
PRO Name argininosuccinate synthase (human)
Definition An argininosuccinate synthase that is encoded in the genome of human.
Short Label hASS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P00966 (ASS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K25 Methylation PhosphoSitePlus
Y29 Phosphorylation PhosphoSitePlus
Y34 Phosphorylation PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
Y83 Phosphorylation PhosphoSitePlus
Y87 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P 18691976, 35016033
T91 Phosphorylation HPRD 18691976, 20068231
S92 Phosphorylation HPRD   PhosphoSitePlus 20068231
C97 Methylation IEDB 31844290
C97 S-Nitrosylation dbSNO 24105792
K101 Ubiquitination PhosphoSitePlus
K112 Acetylation PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
Y113 Phosphorylation PhosphoSitePlus   UniProt 24275569
T119 Phosphorylation PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
S131 Phosphorylation PhosphoSitePlus
C132 S-Nitrosylation dbSNO 15192091, 22178444, 15688001
Y133 Phosphorylation PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus
R153 Methylation PhosphoSitePlus
R157 Methylation PhosphoSitePlus
Y163 Phosphorylation PhosphoSitePlus
K165 Acetylation PhosphoSitePlus   UniProt 28985504
K165 Ubiquitination PhosphoSitePlus
T174 Phosphorylation HPRD   PhosphoSitePlus 20068231
K176 Acetylation UniProt 28985504
K176 Ubiquitination PhosphoSitePlus
S180 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
K199 Ubiquitination PhosphoSitePlus
K209 Acetylation PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
T219 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 24275569, 20068231
K228 Acetylation PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
T242 O-Glycosylation GlyGen 34105348
T243 O-Glycosylation GlyGen 34105348
T246 O-Glycosylation GlyGen 34105348
R272 Methylation PhosphoSitePlus
S278 Phosphorylation PhosphoSitePlus
Y282 Phosphorylation HPRD 20068231
Y291 Phosphorylation PhosphoSitePlus
K310 Ubiquitination PhosphoSitePlus
Y322 Phosphorylation PhosphoSitePlus
K340 Ubiquitination PhosphoSitePlus
K348 Ubiquitination PhosphoSitePlus
S352 Phosphorylation PhosphoSitePlus
Y359 Phosphorylation PhosphoSitePlus
Y383 Phosphorylation PhosphoSitePlus
Y402 Phosphorylation PhosphoSitePlus
K408 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C132 Y132 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R153 W153 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R157 H157 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K209 N209 Biomuta DOID:363 / uterine cancer [ icgc ]
K228 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
T243 N243 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R272 C272 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
R272 H272 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K310 N310 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y322 C322 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]