Protein Information

Cytoscape View


UniProt AC / UniProt ID P00750 / TPA_HUMAN
Protein Name Tissue-type plasminogen activator precursor
Gene Name Name: PLAT
Organism Homo sapiens (Human)

PRO ID PR:P00750
DAG View
PRO Name tissue-type plasminogen activator (human)
Definition A tissue-type plasminogen activator that is encoded in the genome of human.
Short Label hPLAT
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P00750 (PLAT) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T96 O-Glycosylation GlyGen 1900431
C118 S-Nitrosylation dbSNO 1325644, 22178444
N152 N-Glycosylation GlyGen   UniProt 2514791, 24190977, 23090970, ...2226797, 29741879, 2513186, 8687384
N177 N-Glycosylation GlyGen 23090970, 24190977
N219 N-Glycosylation GlyGen 8462541, 1823160, 2514791, ...24190977, 23090970, 2226797, 2513186, 8687384
S456 Phosphorylation PhosphoSitePlus
S473 Phosphorylation PhosphoSitePlus
S474 Phosphorylation PhosphoSitePlus
T477 Phosphorylation PhosphoSitePlus
S478 Phosphorylation PhosphoSitePlus
N483 N-Glycosylation GlyGen 1823160, 2514791, 24190977, ...23090970, 2226797, 2513186, 29741879, 8687384
T487 O-Glycosylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T96 A96 Biomuta DOID:1324 / lung cancer [ cosmic ]
T477 K477 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
N483 K483 Biomuta DOID:3571 / liver cancer [ icgc ]