iPTMnet Report for P00748 (F12)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P00748 / FA12_HUMAN
Protein Name Coagulation factor XII precursor
Gene Name Name: F12
Organism Homo sapiens (Human)

PRO ID PR:P00748
DAG View
PRO Name coagulation factor XII (human)
Definition A coagulation factor XII that is encoded in the genome of human.
Short Label hF12
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P00748 (F12) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y31 Phosphorylation PhosphoSitePlus
T43 O-Glycosylation GlyGen 30459171
Y53 Phosphorylation PhosphoSitePlus
Y58 Phosphorylation PhosphoSitePlus
T109 O-Glycosylation GlyGen   UniProt 1544894
N181 N-Glycosylation GlyGen 29391424
S243 Phosphorylation PhosphoSitePlus
N249 N-Glycosylation GlyGen   UniProt 16335952, 23090970, 3877053, ...3886654
T299 O-Glycosylation GlyGen   UniProt 30459171, 3886654
T305 O-Glycosylation GlyGen   UniProt 3886654
S308 O-Glycosylation GlyGen   UniProt 3886654
T328 O-Glycosylation GlyGen   UniProt 30459171, 3886654
T329 O-Glycosylation GlyGen   UniProt 3886654
T331 Phosphorylation PhosphoSitePlus
S335 O-Glycosylation GlyGen 30459171
T337 O-Glycosylation GlyGen   UniProt 30459171, 3886654
S366 Phosphorylation PhosphoSitePlus
S368 Phosphorylation PhosphoSitePlus
T371 Phosphorylation PhosphoSitePlus
N433 N-Glycosylation GlyGen   UniProt 16335952, 23090970, 14760718, ...29391424, 29741879
R466 Methylation PhosphoSitePlus
C486 Methylation IEDB 31844290


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T43 A43 Biomuta DOID:1324 / lung cancer [ cosmic ]
T305 P305 Biomuta DOID:3571 / liver cancer [ cosmic ]
T328 M328 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R466 S466 Biomuta DOID:9256 / colorectal cancer [ cosmic ]