iPTMnet Report P00747 PLG

Protein Information

UniProt AC / UniProt ID	P00747 / PLMN_HUMAN
Protein Name	Plasminogen precursor
Gene Name	Name: PLG
Organism	Homo sapiens (Human)

PRO ID	PR:P00747 DAG View
PRO Name	plasminogen (human)
Definition	A plasminogen that is encoded in the genome of human.
Short Label	hPLG
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P00747 (PLG) as Substrate

Expanded View

Site	PTM Type	Score	Source	PMID
T28	O-Glycosylation	score1	GlyGen	30459171
S32	Phosphorylation	score1	PhosphoSitePlus
S35	Phosphorylation	score1	PhosphoSitePlus
S45	Phosphorylation	score1	PhosphoSitePlus
S68	Phosphorylation	score1	PhosphoSitePlus
S83	Phosphorylation	score1	PhosphoSitePlus
Y99	Phosphorylation	score1	PhosphoSitePlus
Y111	Phosphorylation	score1	PhosphoSitePlus
N150	N-Glycosylation	score1	GlyGen	29391424
S189	Phosphorylation	score1	PhosphoSitePlus
T200	Phosphorylation	score1	PhosphoSitePlus
T263	O-Glycosylation	score1	GlyGen	30459171
T264	O-Glycosylation	score1	GlyGen	30459171
S268	O-Glycosylation	score3	GlyGen	479158, 2065054, 2386787, ...30459171, 9054441, 1899031, 3356193, 2059624
T279	Phosphorylation	score1	PhosphoSitePlus
N308	N-Glycosylation	score3	GlyGen	2386787, 23090970, 2059624, ...18780401, 1899031, 29741879, 3356193, 29671580, 2065054
S358	O-Glycosylation	score1	GlyGen	30459171
T359	O-Glycosylation	score1	GlyGen	30459171
T365	O-Glycosylation	score3	GlyGen	479158, 2065054, 2386787, ...30459171, 26598643, 9054441, 1899031, 3356193, 2059624
T371	O-Glycosylation	score1	GlyGen	30459171
T422	Phosphorylation	score1	PhosphoSitePlus
N424	N-Glycosylation	score1	GlyGen	29391424
Y425	Phosphorylation	score1	PhosphoSitePlus
T457	O-Glycosylation	score1	GlyGen	30459171
S460	O-Glycosylation	score1	GlyGen	30459171
S477	Phosphorylation	score1	PhosphoSitePlus
S597	Phosphorylation	score3	HPRD phospho.ELM PhosphoSitePlus UniProt	9201958
T662	Phosphorylation	score1	PhosphoSitePlus
T678	Phosphorylation	score1	PhosphoSitePlus
S688	Phosphorylation	score2	PhosphoSitePlus UniProt	24275569
T710	O-Glycosylation	score1	GlyGen	30459171
T742	O-Glycosylation	score1	GlyGen	30459171

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	N308	N-Glycosylation		score3	PRO	1899031, 2059624, 29671580, ...2386787, 2065054

PTM sites affected in variants

Site	Variant	Source	Disease [Sample source]
S45	R45	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S83	T83	Biomuta	DOID:363 / uterine cancer [ icgc ]
S83	F83	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
Y99	*	Biomuta	DOID:4159 / skin cancer [ cosmic ]
N150	I150	Biomuta	DOID:5041 / esophageal cancer [ cosmic ]
T279	K279	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
S358	F358	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
T359	M359	Biomuta	DOID:9256 / colorectal cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
T371	A371	Biomuta	DOID:184 / bone cancer [ cosmic ]
T371	I371	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
T422	I422	Biomuta	DOID:3571 / liver cancer [ cosmic ]
T422	A422	Biomuta	DOID:363 / uterine cancer [ icgc ]
T422	S422	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
S460	R460	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
S688	F688	Biomuta	DOID:4159 / skin cancer [ cosmic ]
T710	N710	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
T710	S710	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
T742	A742	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic, icgc ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P00747 (PLG)

Protein Information

Interactive Sequence View

P00747 (PLG) as Substrate

PTM sites affected in variants