iPTMnet Report for P00738 (HP)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P00738 / HPT_HUMAN
Protein Name Haptoglobin precursor
Gene Name Name: HP
Organism Homo sapiens (Human)

PRO ID PR:P00738
DAG View
PRO Name haptoglobin (human)
Definition A haptoglobin that is encoded in the genome of human.
Short Label hHP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P00738 (HP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y55 Phosphorylation PhosphoSitePlus
Y56 Phosphorylation PhosphoSitePlus
Y66 Phosphorylation PhosphoSitePlus
Y114 Phosphorylation PhosphoSitePlus
Y115 Phosphorylation PhosphoSitePlus
Y125 Phosphorylation PhosphoSitePlus
K170 Acetylation PhosphoSitePlus
N184 N-Glycosylation GlyGen   UniProt 16335952, 34725484, 32125861, ...19159218, 24103369, 18514042, 26869352, 14760718, 23829323, 19139490, 18214858, 24279413, 29391424, 25265424, 17803183, 29741879, 29671580, 29992770, 24841998
T187 O-Glycosylation GlyGen 30459171
N207 N-Glycosylation GlyGen   UniProt 16335952, 34725484, 32125861, ...19159218, 26869352, 14760718, 23829323, 29580922, 18214858, 29391424, 16740002, 17803183, 29741879, 12754519, 29671580
N211 N-Glycosylation GlyGen   UniProt 16335952, 32125861, 19159218, ...26869352, 14760718, 23829323, 29580922, 18214858, 16740002, 17803183, 29741879, 29992770
N241 N-Glycosylation GlyGen   UniProt 24103369, 21780104, 29391424, ...29741879, 16335952, 24530628, 32125861, 14760718, 19139490, 19838169, 24279413, 25265424, 29992770, 19159218, 18214858, 21692080, 18514042, 17803183, 34725484, 30237853, 26869352, 23829323, 24841998, 12754519, 29671580
S243 O-Glycosylation GlyGen 35289036
K251 Ubiquitination PhosphoSitePlus
C266 Methylation IEDB 31844290
C266 S-Nitrosylation dbSNO 25040305
Y272 Phosphorylation PhosphoSitePlus
Y280 Phosphorylation PhosphoSitePlus
C309 S-Nitrosylation dbSNO 25040305
K321 Acetylation PhosphoSitePlus
S326 Phosphorylation PhosphoSitePlus
C340 S-Nitrosylation dbSNO 25040305
C381 S-Nitrosylation dbSNO 25040305
Y386 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N184 N-Glycosylation PRO 24279413, 18214858, 29671580, ...24841998
N207 N-Glycosylation PRO 18214858, 29671580
N211 N-Glycosylation PRO 18214858
N241 N-Glycosylation PRO 29671580, 18214858, 19838169, ...24279413, 24841998


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y125 H125 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S326 N326 Biomuta DOID:4159 / skin cancer [ cosmic ]
C340 R340 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y386 C386 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]