iPTMnet Report for P00558 (PGK1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P00558 / PGK1_HUMAN
Protein Name Phosphoglycerate kinase 1
Gene Name Name: PGK1
Synonyms:PGKA;ORFNames:MIG10,OK/SW-cl.110;
Organism Homo sapiens (Human)

PRO ID PR:P00558
DAG View
PRO Name phosphoglycerate kinase 1 (human)
Definition A phosphoglycerate kinase 1 that is encoded in the genome of human.
Short Label hPGK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P00558 (PGK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22814378
S2 Phosphorylation PhosphoSitePlus   UniProt 23186163
S4 Phosphorylation PhosphoSitePlus   UniProt 23186163
K6 Acetylation PhosphoSitePlus
K6 Ubiquitination PhosphoSitePlus
K11 Acetylation PhosphoSitePlus   UniProt 19608861
K11 Ubiquitination PhosphoSitePlus
K15 Ubiquitination PhosphoSitePlus
K17 Ubiquitination PhosphoSitePlus
K30 Acetylation PhosphoSitePlus
K30 Methylation PhosphoSitePlus
K30 Sumoylation PhosphoSitePlus
K30 Ubiquitination PhosphoSitePlus
T35 O-Glycosylation GlyGen 33214551, 35138101, 30397120, ...34725712, 26853435, 31911580, 34019948, 35083852, 32119511
T35 Phosphorylation PhosphoSitePlus
R39 Methylation PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
S46 O-Glycosylation GlyGen 33214551, 35138101, 30397120, ...34725712, 26853435, 31911580, 34019948, 35083852, 32119511
S46 Phosphorylation PhosphoSitePlus
K48 Acetylation PhosphoSitePlus   UniProt 19608861
K48 Ubiquitination PhosphoSitePlus
C50 Methylation IEDB 31844290
C50 S-Nitrosylation dbSNO 18335467, 22178444, 19366988, ...17629318
K56 Acetylation PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
K75 Acetylation PhosphoSitePlus   UniProt 19608861
K75 Ubiquitination PhosphoSitePlus
Y76 Phosphorylation PhosphoSitePlus
S77 Phosphorylation PhosphoSitePlus
K86 Acetylation PhosphoSitePlus   UniProt 19608861
K86 Ubiquitination PhosphoSitePlus
S87 Phosphorylation PhosphoSitePlus
K91 Acetylation PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
K97 Acetylation PhosphoSitePlus   UniProt 19608861
K97 Ubiquitination PhosphoSitePlus
C99 Methylation IEDB 31844290
C99 S-Nitrosylation dbSNO 20140087, 22178444
K106 Acetylation PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
C108 S-Nitrosylation dbSNO 19483679, 20140087, 22178444, ...19366988, 18335467
S115 Phosphorylation PhosphoSitePlus
R123 Methylation PhosphoSitePlus
K131 Acetylation PhosphoSitePlus   UniProt 19608861
K131 Ubiquitination PhosphoSitePlus
K133 Acetylation PhosphoSitePlus
S136 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
K139 Ubiquitination PhosphoSitePlus
K141 Acetylation PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
K146 Acetylation PhosphoSitePlus   UniProt 19608861
K146 Ubiquitination PhosphoSitePlus
S153 Phosphorylation PhosphoSitePlus
S155 Phosphorylation PhosphoSitePlus
K156 Acetylation PhosphoSitePlus
K156 Ubiquitination PhosphoSitePlus
Y161 Phosphorylation PhosphoSitePlus
T168 Phosphorylation PhosphoSitePlus
S174 O-Glycosylation GlyGen 33214551, 35138101, 30397120, ...34725712, 26853435, 31911580, 34019948, 35083852, 32119511
S175 O-Glycosylation GlyGen 33214551, 35138101, 30397120, ...34725712, 26853435, 31911580, 34019948, 35083852, 32119511
S175 Phosphorylation PhosphoSitePlus
K184 Ubiquitination PhosphoSitePlus
K191 Acetylation PhosphoSitePlus
K191 Methylation PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
Y196 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15592455
K199 Acetylation PhosphoSitePlus   UniProt 19608861
K199 Ubiquitination PhosphoSitePlus
S203 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 17081983, ...31911580, 18669648, 24275569, 31578148, 20068231
K216 Acetylation PhosphoSitePlus
K216 Ubiquitination PhosphoSitePlus
K220 Acetylation PhosphoSitePlus
K220 Ubiquitination PhosphoSitePlus
T243 Phosphorylation PhosphoSitePlus
T255 O-Glycosylation GlyGen 33214551, 35138101, 30397120, ...34725712, 26853435, 31911580, 34019948, 35083852, 32119511
T255 Phosphorylation RLIMS-P 31911580
S256 Phosphorylation PhosphoSitePlus   RLIMS-P 30392930
K264 Acetylation PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus
K267 Acetylation PhosphoSitePlus   UniProt 19608861
K267 Ubiquitination PhosphoSitePlus
S271 Phosphorylation PhosphoSitePlus
K272 Acetylation PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
K275 Acetylation PhosphoSitePlus
K279 Ubiquitination PhosphoSitePlus
T281 Phosphorylation PhosphoSitePlus
T288 Phosphorylation PhosphoSitePlus
K291 Acetylation PhosphoSitePlus   UniProt 19608861
K291 Ubiquitination PhosphoSitePlus
K297 Ubiquitination PhosphoSitePlus
S305 Phosphorylation PhosphoSitePlus
K322 Acetylation PhosphoSitePlus
K322 Ubiquitination PhosphoSitePlus
K323 Acetylation PhosphoSitePlus
K323 Ubiquitination PhosphoSitePlus
Y324 Phosphorylation PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus
K353 Acetylation PhosphoSitePlus
K353 Ubiquitination PhosphoSitePlus
K361 Acetylation PhosphoSitePlus
K361 Ubiquitination PhosphoSitePlus
R365 Methylation PhosphoSitePlus
C367 S-Nitrosylation dbSNO 26338901, 22178444
T378 Phosphorylation PhosphoSitePlus
C379 S-Nitrosylation dbSNO 22178444
C380 S-Nitrosylation dbSNO 22178444
K382 Acetylation PhosphoSitePlus
K382 Ubiquitination PhosphoSitePlus
K388 Acetylation PhosphoSitePlus
K388 Ubiquitination PhosphoSitePlus
S399 Phosphorylation PhosphoSitePlus
K406 Acetylation PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
S415 O-Glycosylation GlyGen 33214551, 35138101, 30397120, ...34725712, 26853435, 31911580, 34019948, 35083852, 32119511
S415 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S57 Phosphorylation HPRD 20068231
S62 Phosphorylation HPRD 20068231
S77 Phosphorylation HPRD 20068231
S136 Phosphorylation HPRD 17287340
Y196 Phosphorylation HPRD 15592455, 20068231
S203 Phosphorylation HPRD 17322306, 18212344, 20230923, ...18767875, 20058876, 19651622, 18510355, 18669648, 18707149, 20166139, 19415658, 20068231
S390 Phosphorylation HPRD 20068231
S393 Phosphorylation HPRD 20068231
S415 Phosphorylation HPRD 20068231


P00558 (PGK1) as PTM Enzyme



Substrate Site Score Source PMID
Q15118 (PDK1) T338 RLIMS-P+ 26942675


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O15379 (HDAC3) S424 P00558 (PGK1) increased_association eFIP 26356530


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S4 C4 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R39 S39 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
R39 M39 Biomuta DOID:1324 / lung cancer [ cosmic ]
S46 N46 Biomuta [ cosmic ]
C108 Y108 Biomuta DOID:363 / uterine cancer [ icgc ]
S115 T115 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
R123 C123 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R123 H123 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ]
S136 F136 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S136 Y136 Biomuta DOID:4159 / skin cancer [ cosmic ]
K156 N156 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K199 N199 Biomuta DOID:363 / uterine cancer [ icgc ]
T255 N255 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S256 F256 Biomuta DOID:1612 / breast cancer [ icgc ]
S271 P271 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T281 I281 Biomuta DOID:4159 / skin cancer [ cosmic ]
S305 F305 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K322 T322 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K322 R322 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R365 G365 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S393 I393 Biomuta DOID:9256 / colorectal cancer [ cosmic ]