iPTMnet Report for P00519 (ABL1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P00519 / ABL1_HUMAN
Protein Name Tyrosine-protein kinase ABL1
Gene Name Name: ABL1
Synonyms:ABL,JTK7;
Organism Homo sapiens (Human)

PRO ID PR:P00519
DAG View
PRO Name tyrosine-protein kinase ABL1 (human)
Definition A tyrosine-protein kinase ABL1 that is encoded in the genome of human.
Short Label hABL1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P00519 (ABL1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S43 Phosphorylation PhosphoSitePlus
S50 Phosphorylation PhosphoSitePlus   UniProt 18691976, 16543148, 19690332
Y70 Phosphorylation neXtProt   PhosphoSitePlus   UniProt 18775435, 16912036
Y70 Phosphorylation P00519 (ABL1) UniProt 16912036
Y70 Phosphorylation P06241 (FYN) PhosphoSitePlus 16912036
Y70 Phosphorylation P07948 (LYN) PhosphoSitePlus 16912036
Y70 Phosphorylation P08631 (HCK) neXtProt   PhosphoSitePlus 18775435, 16912036
S75 Phosphorylation PhosphoSitePlus
Y93 Phosphorylation PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus
Y115 Phosphorylation PhosphoSitePlus   UniProt 16912036
Y115 Phosphorylation P06241 (FYN) PhosphoSitePlus 16912036
Y115 Phosphorylation P07948 (LYN) PhosphoSitePlus 16912036
Y115 Phosphorylation P08631 (HCK) PhosphoSitePlus 16912036
T117 Phosphorylation PhosphoSitePlus
Y128 Phosphorylation PhosphoSitePlus   UniProt 16912036
Y128 Phosphorylation P06241 (FYN) PhosphoSitePlus 16912036
Y128 Phosphorylation P07948 (LYN) PhosphoSitePlus 16912036
Y128 Phosphorylation P08631 (HCK) PhosphoSitePlus 16912036
Y139 Phosphorylation PhosphoSitePlus   UniProt 16912036
Y139 Phosphorylation P06241 (FYN) PhosphoSitePlus 16912036
Y139 Phosphorylation P07948 (LYN) PhosphoSitePlus 16912036
Y139 Phosphorylation P08631 (HCK) PhosphoSitePlus 16912036
S142 Phosphorylation PhosphoSitePlus
Y167 Phosphorylation PhosphoSitePlus
Y172 Phosphorylation PhosphoSitePlus   UniProt 16912036
Y172 Phosphorylation P06241 (FYN) PhosphoSitePlus 16912036
Y172 Phosphorylation P07948 (LYN) PhosphoSitePlus 16912036
Y172 Phosphorylation P08631 (HCK) PhosphoSitePlus 16912036
Y174 Phosphorylation PhosphoSitePlus
S180 Phosphorylation PhosphoSitePlus
Y185 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18083107, 12522270, 16912036
Y185 Phosphorylation P06241 (FYN) PhosphoSitePlus 16912036
Y185 Phosphorylation P07948 (LYN) PhosphoSitePlus 16912036
Y185 Phosphorylation P08631 (HCK) PhosphoSitePlus 16912036
S187 Phosphorylation PhosphoSitePlus
Y215 Phosphorylation PhosphoSitePlus   UniProt 16912036
Y215 Phosphorylation P06241 (FYN) PhosphoSitePlus 16912036
Y215 Phosphorylation P07948 (LYN) PhosphoSitePlus 16912036
Y215 Phosphorylation P08631 (HCK) PhosphoSitePlus 16912036
T224 Phosphorylation PhosphoSitePlus
Y226 Phosphorylation IntAct   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 10964922, 12384576, 16912036, ...12522270, 18775435, 11847100, 12748290
Y226 Phosphorylation P00519 (ABL1) neXtProt   UniProt 12748290, 16912036
Y226 Phosphorylation P06241 (FYN) PhosphoSitePlus 16912036
Y226 Phosphorylation P07948 (LYN) PhosphoSitePlus 16912036
Y226 Phosphorylation P08631 (HCK) PhosphoSitePlus 18775435, 16912036
Y226 Phosphorylation P12931 (SRC) Signor 11847100
S229 Phosphorylation PhosphoSitePlus
Y232 Phosphorylation PhosphoSitePlus
T243 Phosphorylation PhosphoSitePlus
Y253 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y257 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y264 Phosphorylation phospho.ELM   PhosphoSitePlus 12522270
S265 Phosphorylation PhosphoSitePlus
T267 Phosphorylation PhosphoSitePlus
K274 Acetylation PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
T306 Phosphorylation PhosphoSitePlus
Y312 Phosphorylation PhosphoSitePlus
T315 Phosphorylation RLIMS-P 24155950, 31044085
Y320 Phosphorylation PhosphoSitePlus
T389 Phosphorylation PhosphoSitePlus
T392 Phosphorylation PhosphoSitePlus
Y393 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 10964922, 22493660, 11781820, ...11847100, 8441409, 12149456, 12748290, 12522270, 18775435, 16912036
Y393 Phosphorylation A0A173G4P4 (Abl fusion) phospho.ELM 10964922, 11781820
Y393 Phosphorylation P00519 (ABL1) neXtProt   PhosphoSitePlus   Signor   UniProt 11781820, 8441409, 10964922, ...12748290, 16912036
Y393 Phosphorylation P06241 (FYN) PhosphoSitePlus 16912036
Y393 Phosphorylation P07948 (LYN) PhosphoSitePlus 16912036
Y393 Phosphorylation P08631 (HCK) PhosphoSitePlus 18775435, 16912036
Y393 Phosphorylation P12931 (SRC) Signor 11847100
T394 Phosphorylation phospho.ELM   PhosphoSitePlus 12522270
K400 Ubiquitination PhosphoSitePlus
Y413 Phosphorylation PhosphoSitePlus   UniProt 23186163
S417 Phosphorylation PhosphoSitePlus
S446 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   Signor 9168116
S446 Phosphorylation Q13315 (ATM) phospho.ELM   Signor 9168116
Y456 Phosphorylation PhosphoSitePlus
Y469 Phosphorylation PhosphoSitePlus
K512 Ubiquitination PhosphoSitePlus
T532 Phosphorylation PhosphoSitePlus
S535 Phosphorylation PhosphoSitePlus
S559 Phosphorylation PhosphoSitePlus   UniProt 23186163
S569 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 17081983, ...18220336, 17192257, 18669648, 24275569, 19369195, 19690332
T597 Phosphorylation PhosphoSitePlus
S601 Phosphorylation PhosphoSitePlus
T610 Phosphorylation PhosphoSitePlus
T613 Phosphorylation PhosphoSitePlus
S618 Phosphorylation neXtProt   PhosphoSitePlus   Signor   UniProt 18161990
S618 Phosphorylation Q13177 (PAK2) neXtProt   PhosphoSitePlus   Signor 18161990
S619 Phosphorylation neXtProt   PhosphoSitePlus   Signor   UniProt 18161990
S619 Phosphorylation Q13177 (PAK2) neXtProt   PhosphoSitePlus   Signor 18161990
S620 Phosphorylation PhosphoSitePlus   UniProt 23186163
S642 Phosphorylation PhosphoSitePlus
T649 Phosphorylation PhosphoSitePlus
T653 Phosphorylation PhosphoSitePlus
S659 Phosphorylation PhosphoSitePlus   UniProt 18691976
S676 Phosphorylation PhosphoSitePlus
S679 Phosphorylation PhosphoSitePlus
S683 Phosphorylation PhosphoSitePlus   UniProt 23186163
K689 Methylation PhosphoSitePlus
S690 Phosphorylation PhosphoSitePlus
T692 Phosphorylation PhosphoSitePlus
S696 Phosphorylation PhosphoSitePlus
T700 Phosphorylation PhosphoSitePlus
S708 Phosphorylation PhosphoSitePlus
S709 Phosphorylation PhosphoSitePlus
S710 Phosphorylation PhosphoSitePlus
K711 Acetylation PhosphoSitePlus   UniProt 16648821
S718 Phosphorylation PhosphoSitePlus   UniProt 23186163
T735 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 28661474, 18794806, 30704478, ...16888623, 15696159, 30948493, 19804365
T735 Phosphorylation P33981 (TTK) phospho.ELM   PhosphoSitePlus   Signor 18794806
T735 Phosphorylation P41279 (MAP3K8) PhosphoSitePlus 19804365
T735 Phosphorylation P49759 (CLK1) neXtProt   PhosphoSitePlus   Signor 18794806
T735 Phosphorylation Q13043 (STK4) neXtProt   PhosphoSitePlus   Signor 18794806
T735 Phosphorylation Q13188 (STK3) neXtProt   PhosphoSitePlus   Signor 18794806
T735 Phosphorylation Q9HAZ1 (CLK4) neXtProt   PhosphoSitePlus   Signor 18794806
T751 Phosphorylation PhosphoSitePlus   UniProt 23186163
K759 Acetylation PhosphoSitePlus
T781 Phosphorylation PhosphoSitePlus   UniProt 23186163
S805 Phosphorylation PhosphoSitePlus
S808 Phosphorylation PhosphoSitePlus
S809 Phosphorylation PhosphoSitePlus
T814 Phosphorylation PhosphoSitePlus   UniProt 18691976
T823 Phosphorylation PhosphoSitePlus   UniProt 23186163
S840 O-Glycosylation GlyGen 30059200, 28657654, 35254053
T844 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 23186163
T852 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T854 O-Glycosylation GlyGen 31373491
T854 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S855 O-Glycosylation GlyGen 30059200, 28657654, 35254053
S855 Phosphorylation PhosphoSitePlus   UniProt 23186163
S859 Phosphorylation PhosphoSitePlus
S884 Phosphorylation PhosphoSitePlus
S915 Phosphorylation PhosphoSitePlus
S917 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S919 Phosphorylation PhosphoSitePlus
T935 Phosphorylation PhosphoSitePlus
S936 Phosphorylation PhosphoSitePlus
S943 Phosphorylation PhosphoSitePlus
S949 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
T963 Phosphorylation PhosphoSitePlus
S977 Phosphorylation PhosphoSitePlus   UniProt 18691976
Y1064 Phosphorylation PhosphoSitePlus
Y1070 Phosphorylation PhosphoSitePlus
C1100 Methylation IEDB 31844290
S1106 Phosphorylation PhosphoSitePlus
T1111 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S50 Phosphorylation HPRD 18691976
T79 Phosphorylation HPRD 20068231
Y115 Phosphorylation HPRD 16497976
Y185 Phosphorylation HPRD 12522270, 16497976, 18691976
Y226 Phosphorylation HPRD 12522270, 16497976
Y226 Phosphorylation P00519 (ABL1) HPRD 12522270, 16497976
S229 Phosphorylation HPRD 19651622
Y232 Phosphorylation HPRD 16497976
Y253 Phosphorylation HPRD 12522270, 16497976
Y257 Phosphorylation HPRD 12522270, 16497976
Y264 Phosphorylation HPRD 12522270
T392 Phosphorylation HPRD 18691976
Y393 Phosphorylation HPRD 19901323, 18691976, 11781820, ...16497976
Y393 Phosphorylation P12931 (SRC) HPRD 19901323, 18691976, 11781820, ...16497976
T394 Phosphorylation HPRD 12522270, 18707149
S446 Phosphorylation HPRD 8668151, 9168116
S446 Phosphorylation Q13315 (ATM) HPRD 9168116
Y469 Phosphorylation HPRD 12522270
Y469 Phosphorylation P00519 (ABL1) HPRD 12522270
S569 Phosphorylation HPRD 19651622, 18691976, 18669648, ...2183353, 18452278
S569 Phosphorylation P06493 (CDK1) HPRD 19651622, 18691976, 18669648, ...2183353, 18452278
T613 Phosphorylation HPRD 18691976
S618 Phosphorylation HPRD 18691976
S620 Phosphorylation HPRD 18691976
S659 Phosphorylation HPRD 18691976
S683 Phosphorylation HPRD 18691976, 17081983
S710 Phosphorylation HPRD 18691976
S718 Phosphorylation HPRD 18691976
T735 Phosphorylation HPRD   PRO 15696159, 16888623
T781 Phosphorylation HPRD 18691976
S804 Phosphorylation HPRD 19651622, 18691976
S805 Phosphorylation HPRD 19413330, 18691976, 17081983, ...19651622
S808 Phosphorylation HPRD 19651622, 18691976
S809 Phosphorylation HPRD 19413330, 18691976, 17081983, ...19651622
T814 Phosphorylation HPRD 18691976
T844 Phosphorylation HPRD 18691976, 18669648
T852 Phosphorylation HPRD 19413330, 18691976, 18669648
T854 Phosphorylation HPRD 18669648
S855 Phosphorylation HPRD 19413330
S915 Phosphorylation HPRD 18691976, 18452278
S917 Phosphorylation HPRD 19651622, 18691976, 18669648, ...18452278
S919 Phosphorylation HPRD 18691976, 17192257
S919 Phosphorylation P00519 (ABL1) HPRD 18691976, 17192257
S936 Phosphorylation HPRD 18691976
S949 Phosphorylation HPRD 17081983
S977 Phosphorylation HPRD 18691976
S989 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
S16 Phosphorylation PhosphoSitePlus
S69 Phosphorylation HPRD   PhosphoSitePlus 18691976
T98 Phosphorylation HPRD 20068231
Y134 Phosphorylation HPRD   phospho.ELM 16497976
T197 Phosphorylation PhosphoSitePlus 23852372
T197 Phosphorylation Q9NRM7 (LATS2) PhosphoSitePlus 23852372
Y204 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 12522270, 18691976, 16497976
Y245 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 12522270, 16497976
Y245 Phosphorylation P12931 (SRC) HPRD 12522270, 16497976
S248 Phosphorylation HPRD 19651622
Y251 Phosphorylation HPRD   phospho.ELM 12644574, 16497976
Y272 Phosphorylation HPRD   neXtProt   phospho.ELM 12522270, 8702653, 16497976
Y276 Phosphorylation HPRD   phospho.ELM 12522270, 16497976
Y283 Phosphorylation HPRD   phospho.ELM 12522270, 12644574
T411 Phosphorylation HPRD   PhosphoSitePlus 18691976
Y412 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19901323, 11781820, 18691976, ...15592455, 16497976
Y412 Phosphorylation P00519 (ABL1) PhosphoSitePlus 11781820
Y412 Phosphorylation P12931 (SRC) HPRD 19901323, 18691976, 11781820, ...16497976
T413 Phosphorylation HPRD 12522270, 18707149
S465 Phosphorylation HPRD   neXtProt   PhosphoSitePlus 8668151, 9168116
S465 Phosphorylation Q13315 (ATM) neXtProt 9168116
Y488 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 12522270, 22975324, 16464493
Y488 Phosphorylation P12931 (SRC) HPRD   PhosphoSitePlus 12522270, 22975324
S588 Phosphorylation HPRD 19651622, 18691976, 18669648, ...2183353, 18452278
S588 Phosphorylation P06493 (CDK1) HPRD 19651622, 18691976, 18669648, ...2183353, 18452278
T632 Phosphorylation HPRD 18691976
S637 Phosphorylation HPRD 18691976
S639 Phosphorylation HPRD 18691976
S678 Phosphorylation HPRD 18691976
S702 Phosphorylation HPRD 18691976, 17081983
S729 Phosphorylation HPRD 18691976
K730 Acetylation PRO 16648821
K730 Acetylation PR:000007102 (EP300) PRO 16648821
S737 Phosphorylation HPRD 18691976
T754 Phosphorylation HPRD   phospho.ELM 15696159
T800 Phosphorylation HPRD 18691976
S823 Phosphorylation HPRD 19651622, 18691976
S824 Phosphorylation HPRD 19413330, 18691976, 17081983, ...19651622
S827 Phosphorylation HPRD 19651622, 18691976
S828 Phosphorylation HPRD 19413330, 18691976, 17081983, ...19651622
T833 Phosphorylation HPRD 18691976
T863 Phosphorylation HPRD 18691976, 18669648
T871 Phosphorylation HPRD 19413330, 18691976, 18669648
T873 Phosphorylation HPRD 18669648
S874 Phosphorylation HPRD 19413330
K928 Acetylation PhosphoSitePlus
S934 Phosphorylation HPRD 18691976, 18452278
S936 Phosphorylation HPRD 19651622, 18691976, 18669648, ...18452278
S938 Phosphorylation HPRD 18691976, 17192257
S938 Phosphorylation P00519 (ABL1) HPRD 18691976, 17192257
S955 Phosphorylation HPRD 18691976
S968 Phosphorylation HPRD 17081983
S996 Phosphorylation HPRD 18691976
S1008 Phosphorylation HPRD 18691976


P00519 (ABL1) as PTM Enzyme



Substrate Site Score Source PMID
O00213 (APBB1) Y547 neXtProt   Signor 15031292
O00401 (WASL) Y175 HPRD   neXtProt 16199863
O00401 (WASL) Y256 HPRD   neXtProt 19901323, 17389395, 19664994, ...18452278, 16199863, 18707149, 19415658, 20068231
O14818 (PSMA7) Y106 PhosphoSitePlus   Signor 25620702
O14818 (PSMA7) Y153 neXtProt   PhosphoSitePlus   Signor 16678104, 25620702
O15151 (MDM4) Y55 PhosphoSitePlus 19075013
O15151 (MDM4) Y99 PhosphoSitePlus 19075013
O15162-1 (PLSCR1) Y69 HPRD   PhosphoSitePlus   Signor 11390389
O15162-1 (PLSCR1) Y74 HPRD   PhosphoSitePlus   Signor 11390389
O15269 (SPTLC1) Y164 PhosphoSitePlus   Signor 23629659
O15350 (TP73) Y99 HPRD   neXtProt   PhosphoSitePlus   Signor 10391251, 10391250
O43586-1 (PSTPIP1) Y345 HPRD   Signor 11163214
O60234 (GMFG) Y104 Signor 24818551
O60260 (PRKN) Y143 neXtProt   PhosphoSitePlus   Signor 21209200, 20823226
O60504 (SORBS3) Y78 neXtProt 16831423
O60674 (JAK2) Y1007 HPRD   neXtProt 11593427, 15143187, 9111318
O94916 (NFAT5) Y143 PhosphoSitePlus 20585028
O95433 (AHSA1) Y223 PhosphoSitePlus   Signor 26235616
P00519 (ABL1) Y70 UniProt 16912036
P00519 (ABL1) Y226 HPRD   neXtProt   UniProt 12522270, 12748290, 16912036, ...16497976
P00519 (ABL1) Y393 neXtProt   PhosphoSitePlus   Signor   UniProt 11781820, 8441409, 10964922, ...12748290, 16912036
P00519-2 (ABL1) Y412 PhosphoSitePlus 11781820
P00519-1 (ABL1) Y469 HPRD 12522270
P00519-1 (ABL1) S919 HPRD 18691976, 17192257
P00519-2 (ABL1) S938 HPRD 18691976, 17192257
P00533 (EGFR) Y1016 PhosphoSitePlus 16943190
P00533 (EGFR) Y1092 neXtProt   PhosphoSitePlus 16943190
P00533 (EGFR) Y1172 Signor 16943190
P00533 (EGFR) Y1197 neXtProt   PhosphoSitePlus   Signor 16943190
P01112 (HRAS) Y137 PhosphoSitePlus 25999467
P03372 (ESR1) Y52 neXtProt   PhosphoSitePlus   Signor 20101225
P03372 (ESR1) Y219 neXtProt   PhosphoSitePlus   Signor 20101225
P04040 (CAT) Y231 PhosphoSitePlus   Signor 12950161, 12777400
P04040 (CAT) Y386 PhosphoSitePlus   Signor 12950161, 12777400
P04083 (ANXA1) Y21 PhosphoSitePlus 2457390
P05067 (APP) Y757 neXtProt 11279131
P05412 (JUN) Y170 HPRD   neXtProt   PhosphoSitePlus   Signor 10637231
P06400 (RB1) Y805 PhosphoSitePlus   Signor 16158058
P07203-1 (GPX1) Y98 HPRD   neXtProt   PhosphoSitePlus   Signor 12893824
P08581 (MET) Y1349 PhosphoSitePlus 9826708
P08581 (MET) Y1356 PhosphoSitePlus 9826708
P09619 (PDGFRB) Y686 PhosphoSitePlus   Signor 19275932
P09619 (PDGFRB) Y934 PhosphoSitePlus   Signor 19275932
P09619 (PDGFRB) Y970 PhosphoSitePlus   Signor 19275932
P10636-2 (MAPT) Y305 HPRD 16014719
P10636-6 (MAPT) Y336 HPRD 16014719
P10636-8 (MAPT) Y394 HPRD 16014719
P11274 (BCR) Y177 PhosphoSitePlus 16912036, 9178913
P11387 (TOP1) Y268 PhosphoSitePlus   Signor 15448168
P15172 (MYOD1) Y30 neXtProt   Signor 21212806, 12415271
P15391 (CD19) Y508 HPRD   neXtProt   PhosphoSitePlus 11120811
P15498 (VAV1) Y267 PhosphoSitePlus 23325923
P15941 (MUC1) Y1243 Signor 16888623
P16333 (NCK1) Y105 PhosphoSitePlus   Signor 22327338
P17275 (JUNB) Y173 PhosphoSitePlus 26217035
P17275 (JUNB) Y182 PhosphoSitePlus 26217035
P17275 (JUNB) Y188 PhosphoSitePlus 26217035
P17676 (CEBPB) Y78 PhosphoSitePlus   Signor 19563810
P17844 (DDX5) Y593 neXtProt   PhosphoSitePlus   Signor 11823473, 17018282
P17931 (LGALS3) Y79 neXtProt   PhosphoSitePlus   Signor 20150913, 20600357
P17931 (LGALS3) Y107 neXtProt   PhosphoSitePlus   Signor 22232548, 20600357
P17931 (LGALS3) Y118 neXtProt   PhosphoSitePlus   Signor 20150913, 20600357
P19174 (PLCG1) Y771 PhosphoSitePlus 12652307
P19174 (PLCG1) Y1003 PhosphoSitePlus 12652307
P22681 (CBL) Y700 neXtProt 15556646
P25963 (NFKBIA) Y305 PhosphoSitePlus 12167702
P29350-1 (PTPN6) Y536 HPRD   neXtProt   Signor 8692915, 7512963, 8696915, ...16497976
P29350-1 (PTPN6) Y564 HPRD   neXtProt   Signor 10488096, 8696915, 8692915, ...10574931, 12468540, 8114715
P35222 (CTNNB1) Y86 PhosphoSitePlus 17318191
P35222 (CTNNB1) Y489 PhosphoSitePlus 17618275
P35222 (CTNNB1) Y654 PhosphoSitePlus 17318191
P42684 (ABL2) Y261 neXtProt   PhosphoSitePlus   Signor 15735735
P42768 (WAS) Y291 PhosphoSitePlus 12769846
P43351 (RAD52) Y104 HPRD   neXtProt   PhosphoSitePlus   Signor 12379650
P43403 (ZAP70) Y319 neXtProt   PhosphoSitePlus 15268851
P46108 (CRK) Y221 HPRD   neXtProt   PhosphoSitePlus   Signor 11956190, 17016520, 9642287, ...8875975, 25381819, 12198159, 9480911, 8194526, 21779437, 21602891, 12955086, 22327338, 20068231
P46108 (CRK) Y239 PhosphoSitePlus 25381819
P46108 (CRK) Y251 PhosphoSitePlus 21602891, 25381819
P46109 (CRKL) Y207 PhosphoSitePlus 15268851
P46527 (CDKN1B) Y88 HPRD   PhosphoSitePlus   Signor 17908796, 17254966, 22276948
P46527 (CDKN1B) Y89 PhosphoSitePlus 17908796, 21715330
P46937 (YAP1) Y407 neXtProt   PhosphoSitePlus   Signor 18280240
P49023 (PXN) Y31 PhosphoSitePlus 26697169
P49023 (PXN) Y118 PhosphoSitePlus 26697169
P50402 (EMD) Y19 PhosphoSitePlus 19789182
P50402 (EMD) Y41 PhosphoSitePlus 19789182
P50402 (EMD) Y59 PhosphoSitePlus 19789182
P50402 (EMD) Y74 PhosphoSitePlus 19789182
P50402 (EMD) Y85 PhosphoSitePlus 19789182
P50402 (EMD) Y90 PhosphoSitePlus 19789182
P50402 (EMD) Y94 PhosphoSitePlus 19789182
P50402 (EMD) Y95 PhosphoSitePlus 19789182
P50402 (EMD) Y99 PhosphoSitePlus 19789182
P50402 (EMD) Y105 PhosphoSitePlus 19789182
P50402 (EMD) Y155 PhosphoSitePlus 19789182
P50402 (EMD) Y161 PhosphoSitePlus 19789182
P50402 (EMD) Y167 PhosphoSitePlus 19789182
P53350 (PLK1) Y425 Signor 27899378
P55211 (CASP9) Y153 HPRD   neXtProt   PhosphoSitePlus   Signor 15657060
P56962 (STX17) Y157 PhosphoSitePlus 23006999
P63244 (RACK1) Y52 neXtProt   PhosphoSitePlus   Signor 19423701
Q00535 (CDK5) Y15 HPRD   neXtProt 19413330, 18691976, 19901323, ...12372285, 10896159, 20068231, 16497976
Q00987 (MDM2) Y276 PhosphoSitePlus   Signor 16702947, 21081495
Q00987 (MDM2) Y394 PhosphoSitePlus   Signor 16702947, 12110584
Q00987-11 (MDM2) Y400 HPRD 12110584
Q00987 (MDM2) Y405 PhosphoSitePlus   Signor 16702947, 21081495
Q03135 (CAV1) Y14 neXtProt   PhosphoSitePlus 11805080, 12531427
Q03468 (ERCC6) Y932 neXtProt   PhosphoSitePlus   Signor 17626041
Q05086 (UBE3A) Y659 Signor 23581475
Q05655 (PRKCD) Y313 neXtProt 10713049, 17126298
Q06187 (BTK) Y223 HPRD   neXtProt   PhosphoSitePlus   Signor 8630736, 8629002, 11598012, ...12573241, 12445832, 16497976
Q06609 (RAD51) Y54 HPRD   neXtProt   PhosphoSitePlus   RLIMS-P+   Signor 9461559, 19427856
Q06609 (RAD51) Y315 HPRD   PhosphoSitePlus   RLIMS-P+   Signor 19285032, 10212258, 19427856
Q13043 (STK4) Y433 PhosphoSitePlus 21715626
Q13188 (STK3) Y81 PhosphoSitePlus   Signor 22590567
Q13535 (ATR) Y291 neXtProt   PhosphoSitePlus   Signor 20798688
Q13535 (ATR) Y310 neXtProt   PhosphoSitePlus   Signor 20798688
Q13905 (RAPGEF1) Y504 PhosphoSitePlus   Signor 20581864
Q14247 (CTTN) Y421 neXtProt 17306540
Q14247 (CTTN) Y470 neXtProt 17306540
Q14247 (CTTN) Y486 neXtProt   PhosphoSitePlus 17306540, 20861316
Q14498 (RBM39) Y95 RLIMS-P+   Signor 27018250
Q14498 (RBM39) Y99 RLIMS-P+   Signor 27018250
Q14847 (LASP1) Y171 neXtProt   PhosphoSitePlus   Signor 15138294
Q14980 (NUMA1) Y1774 PhosphoSitePlus 22252550
Q15118 (PDK1) Y243 neXtProt   PhosphoSitePlus 22195962
Q15139 (PRKD1) Y432 HPRD   Signor 12637538
Q15139 (PRKD1) Y463 HPRD   neXtProt   PhosphoSitePlus   Signor 12505989, 12637538
Q15139 (PRKD1) Y502 Signor 12637538
Q15746 (MYLK) Y231 neXtProt   PhosphoSitePlus   Signor 20861316
Q15746 (MYLK) Y464 neXtProt   PhosphoSitePlus   Signor 20861316
Q15746 (MYLK) Y556 neXtProt   PhosphoSitePlus   Signor 20861316
Q15746 (MYLK) Y611 neXtProt   PhosphoSitePlus 20861316
Q15746 (MYLK) Y792 neXtProt   PhosphoSitePlus 20861316
Q15746 (MYLK) Y846 neXtProt   PhosphoSitePlus   Signor 20861316
Q15746 (MYLK) Y1449 neXtProt   PhosphoSitePlus 20861316
Q15746 (MYLK) Y1575 neXtProt   PhosphoSitePlus 20861316
Q15746 (MYLK) Y1635 neXtProt   PhosphoSitePlus 20861316
Q6P1J9 (CDC73) Y290 PhosphoSitePlus 21726809
Q6P1J9 (CDC73) Y293 PhosphoSitePlus 21726809
Q6P1J9 (CDC73) Y315 PhosphoSitePlus 21726809
Q6ZUJ8 (PIK3AP1) Y513 neXtProt   PhosphoSitePlus 15893754
Q6ZUJ8 (PIK3AP1) Y553 neXtProt   PhosphoSitePlus 15893754
Q6ZUJ8 (PIK3AP1) Y570 neXtProt   PhosphoSitePlus 15893754
Q6ZUJ8 (PIK3AP1) Y594 neXtProt   PhosphoSitePlus 15893754
Q6ZUJ8 (PIK3AP1) Y694 neXtProt   PhosphoSitePlus 15893754
Q70E73 (RAPH1) Y426 neXtProt 20417104
Q70E73 (RAPH1) Y456 neXtProt 20417104
Q70E73 (RAPH1) Y513 neXtProt 20417104
Q70E73 (RAPH1) Y1226 neXtProt 20417104
Q8IZP0 (ABI1) Y213 neXtProt   PhosphoSitePlus   Signor 21320496, 18328268
Q8WYQ5 (DGCR8) Y267 RLIMS-P+   Signor 26126715
Q92731 (ESR2) Y36 PhosphoSitePlus 24960160
Q92769 (HDAC2) Y222 PhosphoSitePlus 25219501
Q92918-1 (MAP4K1) Y232 HPRD   Signor 11278340
Q92993 (KAT5) Y294 PhosphoSitePlus 24044023
Q99638 (RAD9A) Y28 HPRD   neXtProt   PhosphoSitePlus   Signor 11971963
Q99704 (DOK1) Y362 neXtProt 15148308
Q9BX66 (SORBS1) Y536 neXtProt 19891780
Q9BX66 (SORBS1) Y654 neXtProt 19891780
Q9BX66 (SORBS1) Y1240 neXtProt 19891780
Q9C0H9 (SRCIN1) Y264 PhosphoSitePlus   Signor 23383002
Q9C0H9 (SRCIN1) Y396 PhosphoSitePlus   Signor 23383002
Q9H2X6 (HIPK2) T360 PhosphoSitePlus 25944899
Q9H2X6 (HIPK2) Y367 Signor 25944899
Q9H3D4 (TP63) Y149 PhosphoSitePlus   Signor 19783996
Q9H3D4 (TP63) Y171 PhosphoSitePlus   Signor 19783996
Q9H3D4 (TP63) Y290 PhosphoSitePlus   Signor 19783996
Q9H7P9 (PLEKHG2) Y489 PhosphoSitePlus 24378532
Q9UL17 (TBX21) Y220 PhosphoSitePlus 21690296
Q9UL17 (TBX21) Y266 PhosphoSitePlus 21690296
Q9UL17 (TBX21) Y305 PhosphoSitePlus 21690296
Q9UPY6 (WASF3) Y151 neXtProt   Signor 17623672
Q9UPY6 (WASF3) Y248 neXtProt   Signor 17623672
Q9UPY6 (WASF3) Y337 neXtProt   Signor 17623672
Q9UPY6 (WASF3) Y486 neXtProt   Signor 17623672
Q9Y6N7 (ROBO1) Y1038 PhosphoSitePlus 10892742
Q9Y6N7 (ROBO1) Y1073 PhosphoSitePlus   Signor 10892742
Q9Y6N7 (ROBO1) Y1114 PhosphoSitePlus 10892742
Q9Y6Q9 (NCOA3) Y1357 PhosphoSitePlus   Signor 18765637
Q9Y6W5 (WASF2) Y150 neXtProt 15657136
PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000027696 (hNCOA3/iso:1/Phos:3) pY1357 PR:P00519-1 (hABL1/iso:1) PRO 18765637


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046226 (hABL1/Phos:2) pS446 PRO
PR:000044506 (hABL1/Phos:1) pT735 PRO 15696159, 16888623
PR:000028614 (hABL1/iso:2/Ac:1) acK730 PR:000007102 (EP300) PRO 16648821


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P06400 (RB1) S811 P00519 (ABL1) unknown eFIP 21445688
Phosphorylation P31947 (SFN) S186 P00519 (ABL1) unknown eFIP 19220809
Phosphorylation P46108 (CRK) Y221 P00519 (ABL1) unknown eFIP 8702917
Phosphorylation P50552 (VASP) S157 P00519 (ABL1) decreased_association eFIP 25450971


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000044506 (hABL1/Phos:1) Interaction PR:P63104 (hYWHAZ) PRO 15696159
PR:000044506 (hABL1/Phos:1) Interaction PR:000044507 (fam:14-3-3 (human)) PRO 15696159, 16888623
PR:000044508 (hYWHAZ/Phos:1) decreased Interaction PR:000044506 (hABL1/Phos:1) PRO 15696159
PR:000044509 (hYWHAZ/UnPhos:1) Interaction PR:000044506 (hABL1/Phos:1) PRO 15696159


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y70 H70 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S75 R75 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S75 G75 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y93 C93 Biomuta DOID:3571 / liver cancer [ cosmic ]
S187 F187 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y232 C232 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
T243 I243 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y251 C251 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
Y253 H253 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y253 N253 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y253 F253 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y257 C257 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y264 N264 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y264 C264 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S265 N265 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
T267 M267 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic, icgc ]
Y272 F272 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y272 H272 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y272 N272 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y276 C276 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y283 C283 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y283 N283 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y312 C312 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
T315 I315 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
T315 N315 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T315 L315 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T394 A394 Biomuta DOID:3565 / meningioma [ cosmic ]
K400 E400 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
T413 A413 Biomuta DOID:3565 / meningioma [ cosmic ]
Y413 C413 Biomuta DOID:363 / uterine cancer [ cosmic ]
S417 Y417 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y469 C469 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y488 C488 Biomuta DOID:1324 / lung cancer [ cosmic ]
S601 R601 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S601 G601 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S679 A679 Biomuta DOID:263 / kidney cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S709 F709 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K711 N711 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
K730 N730 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
T823 S823 Biomuta DOID:4159 / skin cancer [ cosmic ]
T852 P852 Biomuta DOID:4159 / skin cancer [ cosmic ]
S859 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S859 L859 Biomuta DOID:1612 / breast cancer [ icgc ]
T871 P871 Biomuta DOID:4159 / skin cancer [ cosmic ]
S915 L915 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K928 N928 Biomuta DOID:363 / uterine cancer [ cosmic ]
S934 L934 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S943 T943 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S977 N977 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S996 N996 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
C1100 Y1100 Biomuta DOID:363 / uterine cancer [ icgc ]
C1100 F1100 Biomuta DOID:2531 / hematologic cancer [ cosmic ]