iPTMnet Report for P00505 (GOT2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P00505 / AATM_HUMAN
Protein Name Aspartate aminotransferase, mitochondrial precursor
Gene Name Name: GOT2
Synonyms:KYAT4;
Organism Homo sapiens (Human)

PRO ID PR:P00505
DAG View
PRO Name aspartate aminotransferase, mitochondrial (human)
Definition An aspartate aminotransferase, mitochondrial that is encoded in the genome of human.
Short Label hGOT2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P00505 (GOT2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T48 Phosphorylation PhosphoSitePlus   UniProt 24275569
K52 Acetylation PhosphoSitePlus
K59 Acetylation PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
Y67 Phosphorylation PhosphoSitePlus
K73 Acetylation PhosphoSitePlus   UniProt 19608861
Y75 Phosphorylation PhosphoSitePlus
S79 Phosphorylation PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
K90 Acetylation PhosphoSitePlus   UniProt 19608861
K90 Ubiquitination PhosphoSitePlus
K94 Acetylation PhosphoSitePlus
K94 Ubiquitination PhosphoSitePlus
Y96 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18083107, 24275569
K107 Acetylation PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
S118 Phosphorylation PhosphoSitePlus
K122 Acetylation PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
T128 Phosphorylation PhosphoSitePlus
T135 Phosphorylation PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
K150 Acetylation PhosphoSitePlus
K150 Methylation PhosphoSitePlus
K159 Acetylation PhosphoSitePlus   UniProt 19608861
T161 Phosphorylation PhosphoSitePlus
T166 Phosphorylation PhosphoSitePlus
K185 Acetylation PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
C187 S-Nitrosylation dbSNO 19483679, 26338901
S199 Phosphorylation PhosphoSitePlus
K227 Acetylation PhosphoSitePlus
T231 Phosphorylation PhosphoSitePlus
K234 Acetylation PhosphoSitePlus   UniProt 19608861
K234 Ubiquitination PhosphoSitePlus
K235 Acetylation PhosphoSitePlus
K256 Acetylation PhosphoSitePlus
K296 Acetylation PhosphoSitePlus   UniProt 19608861
K296 Ubiquitination PhosphoSitePlus
K302 Acetylation PhosphoSitePlus
S306 Phosphorylation PhosphoSitePlus
K309 Acetylation PhosphoSitePlus
Y316 Phosphorylation IEDB   PhosphoSitePlus 32387766
S317 Phosphorylation PhosphoSitePlus
T333 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
K338 Acetylation PhosphoSitePlus
K338 Ubiquitination PhosphoSitePlus
K345 Acetylation PhosphoSitePlus
S360 Phosphorylation PhosphoSitePlus
K363 Acetylation PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus
K364 Acetylation PhosphoSitePlus
K396 Acetylation PhosphoSitePlus   UniProt 19608861
K396 Ubiquitination PhosphoSitePlus
S399 Phosphorylation PhosphoSitePlus
Y401 Phosphorylation phospho.ELM   PhosphoSitePlus 16212419
K404 Acetylation PhosphoSitePlus   UniProt 19608861
K404 Ubiquitination PhosphoSitePlus
K430 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y96 Phosphorylation HPRD 18083107
T128 Phosphorylation HPRD 18491316
T135 Phosphorylation HPRD 18491316
Y401 Phosphorylation HPRD 16212419
T414 Phosphorylation HPRD 20068231
S415 Phosphorylation HPRD 20068231
S416 Phosphorylation HPRD 20068231
Y420 Phosphorylation HPRD 20068231
T429 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K59 N59 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K94 R94 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
C187 * Biomuta DOID:3571 / liver cancer [ cosmic ]
K364 E364 Biomuta DOID:2531 / hematologic cancer [ cosmic ]