iPTMnet Report for P00492 (HPRT1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P00492 / HPRT_HUMAN
Protein Name Hypoxanthine-guanine phosphoribosyltransferase
Gene Name Name: HPRT1
Synonyms:HPRT;
Organism Homo sapiens (Human)

PRO ID PR:P00492
DAG View
PRO Name hypoxanthine-guanine phosphoribosyltransferase (human)
Definition A hypoxanthine-guanine phosphoribosyltransferase that is encoded in the genome of human.
Short Label hHPRT1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P00492 (HPRT1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 7107641
S5 Phosphorylation PhosphoSitePlus
S11 Phosphorylation PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
Y81 Phosphorylation PhosphoSitePlus
S92 Phosphorylation PhosphoSitePlus
T96 Phosphorylation PhosphoSitePlus
K103 Methylation PhosphoSitePlus
K103 Ubiquitination PhosphoSitePlus
S104 Phosphorylation PhosphoSitePlus
C106 S-Nitrosylation dbSNO 19483679, 26338901
S110 Phosphorylation PhosphoSitePlus
K115 Acetylation PhosphoSitePlus
K115 Sumoylation PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
T124 Phosphorylation HPRD 20068231
T126 Phosphorylation HPRD 20068231
K128 Ubiquitination PhosphoSitePlus
T139 Phosphorylation PhosphoSitePlus
T142 Phosphorylation HPRD   PhosphoSitePlus 20068231
T145 Phosphorylation HPRD   PhosphoSitePlus 20068231
S148 Phosphorylation PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
Y198 Phosphorylation PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K73 T73 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S104 I104 Biomuta DOID:1324 / lung cancer [ cosmic ]
K115 R115 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S148 P148 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S148 F148 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ]