iPTMnet Report for P00480 (OTC)
Protein Information
| UniProt AC / UniProt ID | P00480 / OTC_HUMAN |
| Protein Name | Ornithine transcarbamylase, mitochondrial precursor |
| Gene Name | Name: OTC |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P00480 |
| PRO Name | ornithine transcarbamylase, mitochondrial (human) |
| Definition | An ornithine transcarbamylase, mitochondrial that is encoded in the genome of human. |
| Short Label | hOTC |
| Category | organism-gene |
DAG ViewP00480 (OTC) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| K46 | Acetylation | score1 | PhosphoSitePlus | |||
| Y55 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K88 | Acetylation | score3 | PhosphoSitePlus UniProt | 19318352 | ||
| S133 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
| S146 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y223 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K231 | Acetylation | score1 | PhosphoSitePlus | |||
| Y284 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y317 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K46 | T46 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| K46 | R46 | Biomuta | [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] | |
| S133 | G133 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
| Y317 | F317 | Biomuta | DOID:4159 / skin cancer [ cosmic ] |
