iPTMnet Report for P00451 (F8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P00451 / FA8_HUMAN
Protein Name Coagulation factor VIII precursor
Gene Name Name: F8
Synonyms:F8C;
Organism Homo sapiens (Human)

PRO ID PR:P00451
DAG View
PRO Name coagulation factor VIII (human)
Definition A coagulation factor VIII that is encoded in the genome of human.
Short Label hF8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P00451 (F8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S428 Phosphorylation PhosphoSitePlus
Y442 Phosphorylation PhosphoSitePlus
Y450 Phosphorylation PhosphoSitePlus
T451 Phosphorylation PhosphoSitePlus
N601 N-Glycosylation GlyGen   UniProt 16335952
N776 N-Glycosylation GlyGen 29391424
N803 N-Glycosylation GlyGen 29391424
T818 O-Glycosylation GlyGen 30459171
T869 O-Glycosylation GlyGen 30459171
S977 Phosphorylation PhosphoSitePlus
N982 N-Glycosylation GlyGen 29391424
S1013 Phosphorylation PhosphoSitePlus
T1022 Phosphorylation PhosphoSitePlus
S1023 Phosphorylation PhosphoSitePlus
S1026 Phosphorylation PhosphoSitePlus
T1028 Phosphorylation PhosphoSitePlus
N1074 N-Glycosylation GlyGen 29391424
S1084 Phosphorylation PhosphoSitePlus
N1274 N-Glycosylation GlyGen 29391424
T1284 Phosphorylation PhosphoSitePlus
N1301 N-Glycosylation GlyGen 29391424
N1319 N-Glycosylation GlyGen 29391424
S1390 Phosphorylation PhosphoSitePlus
S1396 O-Glycosylation GlyGen 30459171
S1405 Phosphorylation PhosphoSitePlus
S1413 Phosphorylation PhosphoSitePlus
T1424 Phosphorylation PhosphoSitePlus
N1461 N-Glycosylation GlyGen 29391424
T1576 Phosphorylation PhosphoSitePlus
S1578 Phosphorylation PhosphoSitePlus
K1614 Acetylation PhosphoSitePlus
N1824 N-Glycosylation GlyGen 29391424
T1930 Phosphorylation PhosphoSitePlus
T1947 Phosphorylation PhosphoSitePlus
Y1990 Phosphorylation PhosphoSitePlus
N2137 N-Glycosylation GlyGen 29391424
Site PTM Type PTM Enzyme Score Source PMID
T1758 Phosphorylation HPRD 18767875
S1761 Phosphorylation HPRD 18767875
T1763 Phosphorylation HPRD 18767875


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y450 H450 Biomuta DOID:363 / uterine cancer [ cosmic ]
T451 A451 Biomuta DOID:3571 / liver cancer [ cosmic, icgc, tcga ]
S977 N977 Biomuta DOID:4159 / skin cancer [ cosmic ]
N982 S982 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1084 L1084 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1390 L1390 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1413 L1413 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1424 N1424 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T1576 I1576 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1763 A1763 Biomuta DOID:363 / uterine cancer [ icgc ]
N1824 I1824 Biomuta DOID:3571 / liver cancer [ cosmic ]