Protein Information

Cytoscape View

UniProt AC / UniProt ID P00441 / SODC_HUMAN
Protein Name Superoxide dismutase [Cu-Zn]
Gene Name Name: SOD1
Organism Homo sapiens (Human)

PRO ID PR:P00441
DAG View
PRO Name superoxide dismutase [Cu-Zn] (human)
Definition A superoxide dismutase [Cu-Zn] that is encoded in the genome of human.
Short Label hSOD1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P00441 (SOD1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 1463506, 25944712, 7002610
T3 Phosphorylation PhosphoSitePlus
K4 Ubiquitination PhosphoSitePlus
C7 S-Nitrosylation dbSNO 19483679, 24105792, 25040305
K10 Acetylation PhosphoSitePlus
K10 Ubiquitination PhosphoSitePlus
K24 Acetylation PhosphoSitePlus
K24 Ubiquitination PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus
K37 Ubiquitination PhosphoSitePlus
T40 Phosphorylation PhosphoSitePlus
T59 Phosphorylation PhosphoSitePlus
S60 Phosphorylation PhosphoSitePlus   RLIMS-P 24647101
S69 Phosphorylation PhosphoSitePlus
K71 Acetylation PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
K76 Sumoylation PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
R80 Methylation PhosphoSitePlus
N87 N-Glycosylation GlyGen 29741879
T89 Phosphorylation PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
S99 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P   UniProt 24647101, 18669648, 24275569, ...20068231
S103 Phosphorylation HPRD   PhosphoSitePlus   UniProt 24275569, 20230923
S106 Phosphorylation PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus
K123 Acetylation PhosphoSitePlus   UniProt 19608861
K123 Ubiquitination PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
R144 Methylation PhosphoSitePlus
C147 S-Nitrosylation dbSNO 26338901

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 V2 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
T3 M3 Biomuta DOID:363 / uterine cancer [ tcga ]
K4 R4 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S35 R35 Biomuta DOID:2394 / ovarian cancer [ tcga ]
K37 Q37 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
R80 M80 Biomuta DOID:363 / uterine cancer [ tcga ]
S103 F103 Biomuta DOID:363 / uterine cancer [ tcga ]
S108 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]