iPTMnet Report for P00441 (SOD1)
Protein Information
UniProt AC / UniProt ID | P00441 / SODC_HUMAN |
Protein Name | Superoxide dismutase [Cu-Zn] |
Gene Name | Name: SOD1 |
Organism | Homo sapiens (Human) |
PRO ID | PR:P00441 |
PRO Name | superoxide dismutase [Cu-Zn] (human) |
Definition | A superoxide dismutase [Cu-Zn] that is encoded in the genome of human. |
Short Label | hSOD1 |
Category | organism-gene |
P00441 (SOD1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
A2 | Acetylation | score3 | UniProt | 1463506, 25944712, 7002610 | ||
T3 | Phosphorylation | score1 | PhosphoSitePlus | |||
K4 | Ubiquitination | score1 | PhosphoSitePlus | |||
C7 | Methylation | score1 | IEDB | 31844290 | ||
C7 | S-Nitrosylation | score0 | dbSNO | 19483679, 24105792, 25040305 | ||
K10 | Acetylation | score1 | PhosphoSitePlus | |||
K10 | Ubiquitination | score1 | PhosphoSitePlus | |||
K24 | Acetylation | score1 | PhosphoSitePlus | |||
K24 | Ubiquitination | score1 | PhosphoSitePlus | |||
S26 | Phosphorylation | score1 | PhosphoSitePlus | |||
K31 | Ubiquitination | score1 | PhosphoSitePlus | |||
S35 | Phosphorylation | score1 | PhosphoSitePlus | |||
K37 | Ubiquitination | score1 | PhosphoSitePlus | |||
T40 | Phosphorylation | score1 | PhosphoSitePlus | |||
T59 | Phosphorylation | score1 | PhosphoSitePlus | |||
S60 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 24647101 | ||
S69 | Phosphorylation | score1 | PhosphoSitePlus | |||
K71 | Acetylation | score1 | PhosphoSitePlus | |||
K71 | Ubiquitination | score1 | PhosphoSitePlus | |||
K76 | Sumoylation | score1 | PhosphoSitePlus | |||
K76 | Ubiquitination | score1 | PhosphoSitePlus | |||
R80 | Methylation | score1 | PhosphoSitePlus | |||
N87 | N-Glycosylation | score1 | GlyGen | 29741879 | ||
T89 | Phosphorylation | score1 | PhosphoSitePlus | |||
K92 | Ubiquitination | score1 | PhosphoSitePlus | |||
S99 | Phosphorylation | score4 | HPRD PhosphoSitePlus RLIMS-P UniProt | 24647101, 18669648, 24275569, ... | ||
S103 | Phosphorylation | score2 | HPRD PhosphoSitePlus UniProt | 24275569, 20230923 | ||
S106 | Phosphorylation | score1 | PhosphoSitePlus | |||
S108 | Phosphorylation | score1 | PhosphoSitePlus | |||
K123 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
K123 | Ubiquitination | score1 | PhosphoSitePlus | |||
K129 | Ubiquitination | score1 | PhosphoSitePlus | |||
K137 | Ubiquitination | score1 | PhosphoSitePlus | |||
R144 | Methylation | score1 | PhosphoSitePlus | |||
C147 | Methylation | score1 | IEDB | 31844290 | ||
C147 | S-Nitrosylation | score0 | dbSNO | 26338901 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
A2 | V2 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
T3 | M3 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
K4 | R4 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
K10 | R10 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
S35 | R35 | Biomuta | DOID:2394 / ovarian cancer [ cosmic, icgc ] | |
K37 | Q37 | Biomuta | DOID:9256 / colorectal cancer [ icgc ] | |
K37 | T37 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
R80 | M80 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
S103 | F103 | Biomuta | DOID:363 / uterine cancer [ icgc ] |