Protein Information

Cytoscape View


UniProt AC / UniProt ID P00390 / GSHR_HUMAN
Protein Name Glutathione reductase, mitochondrial precursor
Gene Name Name: GSR
Synonyms:GLUR,GRD1;
Organism Homo sapiens (Human)

PRO ID PR:P00390
DAG View
PRO Name glutathione reductase, mitochondrial (human)
Definition A glutathione reductase, mitochondrial that is encoded in the genome of human.
Short Label hGSR
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P00390 (GSR) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y65 Phosphorylation phospho.ELM   PhosphoSitePlus 15592455
K97 Acetylation PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
C107 S-Nitrosylation dbSNO 25040305
K110 Acetylation PhosphoSitePlus
Y158 Phosphorylation PhosphoSitePlus
K164 Acetylation PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
K181 Ubiquitination PhosphoSitePlus
K189 Acetylation PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus
K190 Acetylation PhosphoSitePlus
C278 S-Nitrosylation dbSNO 25040305
K291 Ubiquitination PhosphoSitePlus
K296 Ubiquitination PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
T301 Phosphorylation PhosphoSitePlus
S308 Phosphorylation PhosphoSitePlus
K340 Ubiquitination PhosphoSitePlus
K346 Ubiquitination PhosphoSitePlus
K354 Ubiquitination PhosphoSitePlus
K368 Ubiquitination PhosphoSitePlus
Y371 Phosphorylation PhosphoSitePlus
C377 S-Nitrosylation dbSNO 25040305
K379 Ubiquitination PhosphoSitePlus
T383 Phosphorylation PhosphoSitePlus
K401 Acetylation PhosphoSitePlus
K401 Ubiquitination PhosphoSitePlus
K405 Ubiquitination PhosphoSitePlus
Y408 Phosphorylation PhosphoSitePlus
T427 Phosphorylation PhosphoSitePlus
K434 Ubiquitination PhosphoSitePlus
K441 Ubiquitination PhosphoSitePlus
S446 Phosphorylation PhosphoSitePlus
T448 Phosphorylation PhosphoSitePlus
Y451 Phosphorylation PhosphoSitePlus
T455 Phosphorylation PhosphoSitePlus
K456 Acetylation PhosphoSitePlus
K456 Ubiquitination PhosphoSitePlus
K464 Ubiquitination PhosphoSitePlus
K470 Acetylation PhosphoSitePlus
K470 Ubiquitination PhosphoSitePlus
C484 S-Nitrosylation dbSNO 25040305
K501 Ubiquitination PhosphoSitePlus
T507 Phosphorylation PhosphoSitePlus   RLIMS-P 31530934
T513 Phosphorylation PhosphoSitePlus
S514 Phosphorylation PhosphoSitePlus
S515 Phosphorylation PhosphoSitePlus
R522 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T455 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K110 R110 Biomuta DOID:1324 / lung cancer [ cosmic ]
K181 N181 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K300 T300 Biomuta DOID:3070 / malignant glioma [ tcga ]
S308 N308 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K340 E340 Biomuta DOID:363 / uterine cancer [ tcga ]
Y371 * Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
Y451 H451 Biomuta DOID:0070003 / blastoma [ cosmic ]
T455 N455 Biomuta DOID:1115 / sarcoma [ tcga ]
K456 R456 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
K456 T456 Biomuta DOID:363 / uterine cancer [ tcga ]
S514 P514 Biomuta DOID:263 / kidney cancer [ tcga ]
R522 H522 Biomuta DOID:0070003 / blastoma [ cosmic ]
R522 C522 Biomuta DOID:3070 / malignant glioma [ tcga ]