iPTMnet Report for P00387 (CYB5R3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P00387 / NB5R3_HUMAN
Protein Name NADH-cytochrome b5 reductase 3
Gene Name Name: CYB5R3
Synonyms:DIA1;
Organism Homo sapiens (Human)

PRO ID PR:P00387
DAG View
PRO Name NADH-cytochrome b5 reductase 3 (human)
Definition An NADH-cytochrome b5 reductase 3 that is encoded in the genome of human.
Short Label hCYB5R3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P00387 (CYB5R3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
G2 Myristoylation UniProt 2498303, 25255805
S21 Phosphorylation PhosphoSitePlus
S30 O-Glycosylation GlyGen 34019948, 25367160, 32870666
T31 O-Glycosylation GlyGen 34019948, 25367160, 32870666
T31 Phosphorylation PhosphoSitePlus
S38 Phosphorylation PhosphoSitePlus
K42 Acetylation PhosphoSitePlus   UniProt 19608861
K42 Ubiquitination PhosphoSitePlus
Y43 Phosphorylation PhosphoSitePlus   UniProt 18669648
S66 Phosphorylation PhosphoSitePlus
Y80 Phosphorylation PhosphoSitePlus
S82 Phosphorylation PhosphoSitePlus
T95 Phosphorylation PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
K120 Acetylation PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
S146 Phosphorylation PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
T171 Phosphorylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
S174 Phosphorylation PhosphoSitePlus
T182 Phosphorylation PhosphoSitePlus
T185 Phosphorylation PhosphoSitePlus
K196 Acetylation PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
Y248 Phosphorylation PhosphoSitePlus
C298 Methylation IEDB 31844290
Site PTM Type PTM Enzyme Score Source PMID
Y43 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
Y20 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S30 P30 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S38 R38 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S82 L82 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K126 E126 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S174 F174 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T185 I185 Biomuta DOID:4159 / skin cancer [ cosmic ]